MS4A3

MS4A3
Identifiers
Aliases	MS4A3 , CD20L, HTM4, membrane spanning 4-domains A3
External IDs	OMIM: 606498 MGI: 2158468 HomoloGene: 4472 GeneCards: MS4A3
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q12.1 Start 60,056,587 bp [1] End 60,071,115 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19|19 A Start 11,606,860 bp [2] End 11,618,215 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in bone marrow bone marrow cells monocyte blood spleen right lung placenta appendix upper lobe of left lung gallbladder Top expressed in bone marrow right ventricle body of femur olfactory epithelium medial ganglionic eminence spleen cochlea sexually immature organism carotid body digastric muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding Cellular component cytoplasm perinuclear region of cytoplasm integral component of membrane membrane endomembrane system plasma membrane specific granule membrane Biological process regulation of cell cycle neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 932 170813 Ensembl ENSG00000149516 ENSG00000284903 ENSMUSG00000024681 UniProt Q96HJ5 Q920C4 RefSeq (mRNA) NM_001031666 NM_001031809 NM_006138 NM_133246 RefSeq (protein) NP_001026836 NP_001026979 NP_006129 NP_573509 Location (UCSC) Chr 11: 60.06 – 60.07 Mb Chr 19: 11.61 – 11.62 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Membrane-spanning 4-domains subfamily A member 3 is a protein that in humans is encoded by the MS4A3 gene. ^{[5] [6]}

This gene encodes a member of the membrane-spanning 4A gene family. Members of this protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member likely plays a role in signal transduction and may function as a subunit associated with receptor complexes. The gene encoding this protein is localized to 11q12, among a cluster of related family members. Alternative splicing may result in multiple transcript variants; however, not all variants have been fully described. ^[6]

Interactions

MS4A3 has been shown to interact with CDKN3. ^[7]

References

1. ENSG00000284903 GRCh38: Ensembl release 89: ENSG00000149516, ENSG00000284903 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024681 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Adra CN, Lelias JM, Kobayashi H, Kaghad M, Morrison P, Rowley JD, Lim B (Nov 1994). "Cloning of the cDNA for a hematopoietic cell-specific protein related to CD20 and the beta subunit of the high-affinity IgE receptor: evidence for a family of proteins with four membrane-spanning regions". Proc Natl Acad Sci U S A. 91 (21): 10178–82. Bibcode:1994PNAS...9110178A. doi: 10.1073/pnas.91.21.10178 . PMC   44981 . PMID   7524084.
6. "Entrez Gene: MS4A3 membrane-spanning 4-domains, subfamily A, member 3 (hematopoietic cell-specific)".
7. Donato, José L; Ko Jon; Kutok Jeffery L; Cheng Tao; Shirakawa Taro; Mao Xiao-Quan; Beach David; Scadden David T; Sayegh Mohamed H; Adra Chaker N (Jan 2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. United States. 109 (1): 51–8. doi:10.1172/JCI14025. ISSN   0021-9738. PMC   150822 . PMID   11781350.

Further reading

• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Chinami M, Yano Y, Yang X, et al. (2005). "Binding of HTm4 to cyclin-dependent kinase (Cdk)-associated phosphatase (KAP).Cdk2.cyclin A complex enhances the phosphatase activity of KAP, dissociates cyclin A, and facilitates KAP dephosphorylation of Cdk2". J. Biol. Chem. 280 (17): 17235–42. doi: 10.1074/jbc.M413437200 . PMID   15671017.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Donato JL, Ko J, Kutok JL, et al. (2002). "Human HTm4 is a hematopoietic cell cycle regulator". J. Clin. Invest. 109 (1): 51–8. doi:10.1172/JCI14025. PMC   150822 . PMID   11781350.
• Liang Y, Buckley TR, Tu L, et al. (2001). "Structural organization of the human MS4A gene cluster on Chromosome 11q12". Immunogenetics. 53 (5): 357–68. doi:10.1007/s002510100339. PMID   11486273. S2CID   21846867.
• Liang Y, Tedder TF (2001). "Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse". Genomics. 72 (2): 119–27. doi:10.1006/geno.2000.6472. PMID   11401424.