CD37

Last updated
CD37
Identifiers
Aliases CD37 , GP52-40, TSPAN26, CD37 molecule
External IDs OMIM: 151523 MGI: 88330 HomoloGene: 20422 GeneCards: CD37
Orthologs
SpeciesHumanMouse
Entrez

951

12493

Ensembl

ENSG00000104894

ENSMUSG00000030798

UniProt

P11049

Q61470

RefSeq (mRNA)

NM_001040031
NM_001774

NM_007645
NM_001290802
NM_001290804

RefSeq (protein)

NP_001035120
NP_001765

NP_001277731
NP_001277733
NP_031671

Location (UCSC) Chr 19: 49.34 – 49.34 Mb Chr 7: 44.88 – 44.89 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene. [5] [6]

Contents

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic transmembrane domains. Tetraspanins mediate signal transduction events that play a role in the regulation of immune responses, cell development, activation, growth and motility. [7] [8] [9] [10] CD37 expression is restricted to cells of the immune system, with highest abundance on mature B cells, and lower expression is found on T cells and myeloid cells. CD37 is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternate splicing results in multiple transcript variants encoding different isoforms. [6] CD37 controls both humoral [11] [12] and cellular immune responses. [13] [14] [15] CD37-deficiency in mice leads to spontaneous development on B cell lymphoma, [16] and patients with CD37-negative lymphomas have a worse clinical outcome. [17]

See also

Related Research Articles

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<span class="mw-page-title-main">Integrin alpha L</span> Mammalian protein found in Homo sapiens

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<span class="mw-page-title-main">CD19</span> Biomarker for B cell lineage

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<span class="mw-page-title-main">CD9</span> Human protein-encoding gene

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<span class="mw-page-title-main">CD53</span> Mammalian protein found in Homo sapiens

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<span class="mw-page-title-main">CD63</span>

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<span class="mw-page-title-main">CD151</span> Protein-coding gene in the species Homo sapiens

CD151 molecule, also known as CD151, is a human gene.

<span class="mw-page-title-main">ICAM3</span> Mammalian protein found in Homo sapiens

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<span class="mw-page-title-main">CD81</span>

CD81 molecule, also known as CD81, is a protein which in humans is encoded by the CD81 gene. It is also known as 26 kDa cell surface protein, TAPA-1, and Tetraspanin-28 (Tspan-28).

<i>CD82</i> (gene) Mammalian protein found in Homo sapiens

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<span class="mw-page-title-main">TSPAN7</span> Protein-coding gene in humans

Tetraspanin-7 is a protein that in humans is encoded by the TSPAN7 gene.

<span class="mw-page-title-main">TM4SF1</span> Protein-coding gene in the species Homo sapiens

Transmembrane 4 L6 family member 1 is a protein that in humans is encoded by the TM4SF1 gene.

<span class="mw-page-title-main">TSPAN4</span> Protein-coding gene in humans

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.

<span class="mw-page-title-main">TSPAN8</span> Protein-coding gene in humans

Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene.

<span class="mw-page-title-main">CD79A</span> Mammalian protein found in Homo sapiens

Cluster of differentiation CD79A also known as B-cell antigen receptor complex-associated protein alpha chain and MB-1 membrane glycoprotein, is a protein that in humans is encoded by the CD79A gene.

<span class="mw-page-title-main">TM4SF5</span> Protein-coding gene in the species Homo sapiens

Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000104894 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030798 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Virtaneva KI, Angelisová P, Baumruker T, Horejsí V, Nevanlinna H, Schröder J (Mar 1993). "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes". Immunogenetics. 37 (6): 461–5. doi:10.1007/BF00222471. hdl: 10138/157839 . PMID   8436422. S2CID   8899453.
  6. 1 2 "Entrez Gene: CD37 CD37 molecule".
  7. ↑ Levy S, Shoham T (February 2005). "The tetraspanin web modulates immune-signalling complexes". Nature Reviews. Immunology. 5 (2): 136–48. doi:10.1038/nri1548. PMID   15688041. S2CID   1756810.
  8. ↑ Charrin S, le Naour F, Silvie O, Milhiet PE, Boucheix C, Rubinstein E (May 2009). "Lateral organization of membrane proteins: tetraspanins spin their web". The Biochemical Journal. 420 (2): 133–54. doi:10.1042/BJ20082422. PMID   19426143.
  9. ↑ Hemler ME (October 2005). "Tetraspanin functions and associated microdomains". Nature Reviews Molecular Cell Biology. 6 (10): 801–11. doi:10.1038/nrm1736. PMID   16314869. S2CID   5906694.
  10. ↑ van Deventer SJ, Dunlock VE, van Spriel AB (2017-06-15). "Molecular interactions shaping the tetraspanin web". Biochemical Society Transactions. 45 (3): 741–750. doi: 10.1042/BST20160284 . PMID   28620035.
  11. ↑ van Spriel AB, Sofi M, Gartlan KH, van der Schaaf A, Verschueren I, Torensma R, Raymakers RA, Loveland BE, Netea MG, Adema GJ, Wright MD, Figdor CG (March 2009). "The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity". PLOS Pathogens. 5 (3): e1000338. doi: 10.1371/journal.ppat.1000338 . PMC   2650281 . PMID   19282981.
  12. ↑ van Spriel AB, de Keijzer S, van der Schaaf A, Gartlan KH, Sofi M, Light A, Linssen PC, Boezeman JB, Zuidscherwoude M, Reinieren-Beeren I, Cambi A, Mackay F, Tarlinton DM, Figdor CG, Wright MD (November 2012). "The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports long-lived plasma cell survival". Science Signaling. 5 (250): ra82. doi:10.1126/scisignal.2003113. PMID   23150881. S2CID   21237789.
  13. ↑ Knobeloch KP, Wright MD, Ochsenbein AF, Liesenfeld O, Löhler J, Zinkernagel RM, Horak I, Orinska Z (August 2000). "Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions". Molecular and Cellular Biology. 20 (15): 5363–9. doi:10.1128/MCB.20.15.5363-5369.2000. PMC   85988 . PMID   10891477.
  14. ↑ van Spriel AB, Puls KL, Sofi M, Pouniotis D, Hochrein H, Orinska Z, Knobeloch KP, Plebanski M, Wright MD (March 2004). "A regulatory role for CD37 in T cell proliferation". Journal of Immunology. 172 (5): 2953–61. doi:10.4049/jimmunol.172.5.2953. PMID   14978098. S2CID   5620186.
  15. ↑ Sheng KC, van Spriel AB, Gartlan KH, Sofi M, Apostolopoulos V, Ashman L, Wright MD (January 2009). "Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC". European Journal of Immunology. 39 (1): 50–5. doi:10.1002/eji.200838798. PMID   19089816. S2CID   46297687.
  16. ↑ de Winde CM, Veenbergen S, Young KH, Xu-Monette ZY, Wang XX, Xia Y, Jabbar KJ, van den Brand M, van der Schaaf A, Elfrink S, van Houdt IS, Gijbels MJ, van de Loo FA, Bennink MB, Hebeda KM, Groenen PJ, van Krieken JH, Figdor CG, van Spriel AB (February 2016). "Tetraspanin CD37 protects against the development of B cell lymphoma". The Journal of Clinical Investigation. 126 (2): 653–66. doi:10.1172/JCI81041. PMC   4731177 . PMID   26784544.
  17. ↑ Xu-Monette ZY, Li L, Byrd JC, Jabbar KJ, Manyam GC, Maria de Winde C, van den Brand M, Tzankov A, Visco C, Wang J, Dybkaer K, Chiu A, Orazi A, Zu Y, Bhagat G, Richards KL, Hsi ED, Choi WW, Huh J, Ponzoni M, Ferreri AJ, Møller MB, Parsons BM, Winter JN, Wang M, Hagemeister FB, Piris MA, Han van Krieken J, Medeiros LJ, Li Y, van Spriel AB, Young KH (December 2016). "Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma". Blood. 128 (26): 3083–3100. doi:10.1182/blood-2016-05-715094. PMC   5201094 . PMID   27760757.

Further reading

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