CD37

Last updated

CD37
Identifiers
Aliases CD37 , GP52-40, TSPAN26, CD37 molecule
External IDs OMIM: 151523; MGI: 88330; HomoloGene: 20422; GeneCards: CD37; OMA:CD37 - orthologs
Orthologs
SpeciesHumanMouse
Entrez

951

12493

Ensembl

ENSG00000104894

ENSMUSG00000030798

UniProt

P11049

Q61470

RefSeq (mRNA)

NM_001040031
NM_001774

NM_007645
NM_001290802
NM_001290804

RefSeq (protein)

NP_001035120
NP_001765

NP_001277731
NP_001277733
NP_031671

Location (UCSC) Chr 19: 49.34 – 49.34 Mb Chr 7: 44.88 – 44.89 Mb
PubMed search [3] [4]
Wikidata
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Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene. [5] [6]

Contents

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic transmembrane domains. Tetraspanins mediate signal transduction events that play a role in the regulation of immune responses, cell development, activation, growth and motility. [7] [8] [9] [10] CD37 expression is restricted to cells of the immune system, with highest abundance on mature B cells, and lower expression is found on T cells and myeloid cells. CD37 is a cell surface glycoprotein that is known to complex with integrins and other transmembrane 4 superfamily proteins. Alternate splicing results in multiple transcript variants encoding different isoforms. [6] CD37 controls both humoral [11] [12] and cellular immune responses. [13] [14] [15] CD37-deficiency in mice leads to spontaneous development on B cell lymphoma, [16] and patients with CD37-negative lymphomas have a worse clinical outcome. [17]

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000104894 – Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000030798 – Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Virtaneva KI, Angelisová P, Baumruker T, Horejsí V, Nevanlinna H, Schröder J (Mar 1993). "The genes for CD37, CD53, and R2, all members of a novel gene family, are located on different chromosomes". Immunogenetics. 37 (6): 461–5. doi:10.1007/BF00222471. hdl: 10138/157839 . PMID   8436422. S2CID   8899453.
  6. 1 2 "Entrez Gene: CD37 CD37 molecule".
  7. ↑ Levy S, Shoham T (February 2005). "The tetraspanin web modulates immune-signalling complexes". Nature Reviews. Immunology. 5 (2): 136–48. doi:10.1038/nri1548. PMID   15688041. S2CID   1756810.
  8. ↑ Charrin S, le Naour F, Silvie O, Milhiet PE, Boucheix C, Rubinstein E (May 2009). "Lateral organization of membrane proteins: tetraspanins spin their web". The Biochemical Journal. 420 (2): 133–54. doi:10.1042/BJ20082422. PMID   19426143.
  9. ↑ Hemler ME (October 2005). "Tetraspanin functions and associated microdomains". Nature Reviews Molecular Cell Biology. 6 (10): 801–11. doi:10.1038/nrm1736. PMID   16314869. S2CID   5906694.
  10. ↑ van Deventer SJ, Dunlock VE, van Spriel AB (2017-06-15). "Molecular interactions shaping the tetraspanin web". Biochemical Society Transactions. 45 (3): 741–750. doi: 10.1042/BST20160284 . PMID   28620035.
  11. ↑ van Spriel AB, Sofi M, Gartlan KH, van der Schaaf A, Verschueren I, Torensma R, et al. (March 2009). "The tetraspanin protein CD37 regulates IgA responses and anti-fungal immunity". PLOS Pathogens. 5 (3): e1000338. doi: 10.1371/journal.ppat.1000338 . PMC   2650281 . PMID   19282981.
  12. ↑ van Spriel AB, de Keijzer S, van der Schaaf A, Gartlan KH, Sofi M, Light A, et al. (November 2012). "The tetraspanin CD37 orchestrates the α(4)β(1) integrin-Akt signaling axis and supports long-lived plasma cell survival". Science Signaling. 5 (250): ra82. doi:10.1126/scisignal.2003113. PMID   23150881. S2CID   21237789.
  13. ↑ Knobeloch KP, Wright MD, Ochsenbein AF, Liesenfeld O, Löhler J, Zinkernagel RM, et al. (August 2000). "Targeted inactivation of the tetraspanin CD37 impairs T-cell-dependent B-cell response under suboptimal costimulatory conditions". Molecular and Cellular Biology. 20 (15): 5363–9. doi:10.1128/MCB.20.15.5363-5369.2000. PMC   85988 . PMID   10891477.
  14. ↑ van Spriel AB, Puls KL, Sofi M, Pouniotis D, Hochrein H, Orinska Z, et al. (March 2004). "A regulatory role for CD37 in T cell proliferation". Journal of Immunology. 172 (5): 2953–61. doi:10.4049/jimmunol.172.5.2953. PMID   14978098. S2CID   5620186.
  15. ↑ Sheng KC, van Spriel AB, Gartlan KH, Sofi M, Apostolopoulos V, Ashman L, et al. (January 2009). "Tetraspanins CD37 and CD151 differentially regulate Ag presentation and T-cell co-stimulation by DC". European Journal of Immunology. 39 (1): 50–5. doi:10.1002/eji.200838798. PMID   19089816. S2CID   46297687.
  16. ↑ de Winde CM, Veenbergen S, Young KH, Xu-Monette ZY, Wang XX, Xia Y, et al. (February 2016). "Tetraspanin CD37 protects against the development of B cell lymphoma". The Journal of Clinical Investigation. 126 (2): 653–66. doi:10.1172/JCI81041. PMC   4731177 . PMID   26784544.
  17. ↑ Xu-Monette ZY, Li L, Byrd JC, Jabbar KJ, Manyam GC, Maria de Winde C, et al. (December 2016). "Assessment of CD37 B-cell antigen and cell of origin significantly improves risk prediction in diffuse large B-cell lymphoma". Blood. 128 (26): 3083–3100. doi:10.1182/blood-2016-05-715094. PMC   5201094 . PMID   27760757.

Further reading

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