MS4A7

MS4A7
Identifiers
Aliases	MS4A7 , 4SPAN2, CD20L4, CFFM4, MS4A8, membrane spanning 4-domains A7
External IDs	OMIM: 606502 MGI: 1918846 HomoloGene: 10922 GeneCards: MS4A7
Gene location (Human)
Chr.	Chromosome 11 (human)
End	60,395,951 bp
Gene location (Mouse)
Chr.	Chromosome 19 (mouse)
End	11,313,510 bp
RNA expression pattern
	Top expressed in
	monocyte; ; spleen; ; gallbladder; ; appendix; ; upper lobe of left lung; ; right lung; ; rectum; ; cancellous bone; ; lower lobe of lung; ; right coronary artery;
	Top expressed in
	interventricular septum; ; calvaria; ; internal carotid artery; ; cervix; ; external carotid artery; ; thymus; ; spleen; ; duodenum; ; dermis; ; ileum;
	More reference expression data
	n/a
Orthologs
	58475
	109225
	ENSG00000166927
	ENSMUSG00000024672
	Q9GZW8
	n/a
	NM_206940 ; NM_021201 ; NM_206938 ; NM_206939
	NM_001025610 ; NM_001276398 ; NM_027836
	NP_067024 ; NP_996821 ; NP_996822 ; NP_996823
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated June 15, 2023

Membrane-spanning 4-domains subfamily A member 7 is a protein that in humans is encoded by the MS4A7 gene.^[5]^[6]^[7]

This gene encodes a member of the membrane-spanning 4A gene family, members of which are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns in hematopoietic cells and nonlymphoid tissues. This family member is associated with mature cellular function in the monocytic lineage, and it may be a component of a receptor complex involved in signal transduction. This gene is localized to 11q12, in a cluster of other family members. At least four alternatively spliced transcript variants encoding two distinct isoforms have been observed.^[7]

Related Research Articles

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References

1 2 3 GRCh38: Ensembl release 89: ENSG00000166927 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024672 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Ishibashi K, Suzuki M, Sasaki S, Imai M (Mar 2001). "Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor". Gene. 264 (1): 87–93. doi:10.1016/S0378-1119(00)00598-9. PMID 11245982.
↑ Liang Y, Tedder TF (Jun 2001). "Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse". Genomics. 72 (2): 119–27. doi:10.1006/geno.2000.6472. PMID 11401424.
1 2 "Entrez Gene: MS4A7 membrane-spanning 4-domains, subfamily A, member 7".

Liang Y, Buckley TR, Tu L, et al. (2001). "Structural organization of the human MS4A gene cluster on Chromosome 11q12". Immunogenetics. 53 (5): 357–68. doi:10.1007/s002510100339. PMID 11486273. S2CID 21846867.
Gingras MC, Lapillonne H, Margolin JF (2001). "CFFM4: a new member of the CD20/FcepsilonRIbeta family". Immunogenetics. 53 (6): 468–76. doi:10.1007/s002510100345. PMID 11685457. S2CID 29981957.
Xu XR, Huang J, Xu ZG, et al. (2002). "Insight into hepatocellular carcinogenesis at transcriptome level by comparing gene expression profiles of hepatocellular carcinoma with those of corresponding noncancerous liver". Proc. Natl. Acad. Sci. U.S.A. 98 (26): 15089–94. Bibcode:2001PNAS...9815089X. doi: 10.1073/pnas.241522398 . PMC 64988 . PMID 11752456.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID 16303743.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000166927 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000024672 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid11245982-5] Ishibashi K, Suzuki M, Sasaki S, Imai M (Mar 2001). "Identification of a new multigene four-transmembrane family (MS4A) related to CD20, HTm4 and beta subunit of the high-affinity IgE receptor". Gene. 264 (1): 87–93. doi:10.1016/S0378-1119(00)00598-9. PMID 11245982.

[pmid11401424-6] Liang Y, Tedder TF (Jun 2001). "Identification of a CD20-, FcepsilonRIbeta-, and HTm4-related gene family: sixteen new MS4A family members expressed in human and mouse". Genomics. 72 (2): 119–27. doi:10.1006/geno.2000.6472. PMID 11401424.

[entrez-7] 1 2 "Entrez Gene: MS4A7 membrane-spanning 4-domains, subfamily A, member 7".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

v t e Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders

MS4A7

Related Research Articles

References

Further reading