TSPAN31

TSPAN31
Identifiers
Aliases	TSPAN31 , SAS, tetraspanin 31
External IDs	OMIM: 181035; MGI: 1914375; HomoloGene: 4359; GeneCards: TSPAN31; OMA:TSPAN31 - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12q14.1 Start 57,738,013 bp [1] End 57,750,219 bp [1]
Gene location (Mouse) Chr. Chromosome 10 (mouse) [2] Band 10|10 D3 Start 126,903,149 bp [2] End 126,906,133 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in pancreatic ductal cell islet of Langerhans pericardium right lobe of thyroid gland right adrenal gland corpus epididymis endothelial cell right adrenal cortex renal medulla gallbladder Top expressed in left lobe of liver medullary collecting duct renal corpuscle calvaria cumulus cell medial ganglionic eminence molar vas deferens efferent ductule aortic valve More reference expression data BioGPS More reference expression data
Orthologs Species Human Mouse Entrez 6302 67125 Ensembl ENSG00000135452 ENSMUSG00000006736 UniProt Q12999 Q9CQ88 RefSeq (mRNA) NM_005981 NM_001330168 NM_001330169 NM_025982 RefSeq (protein) NP_001317097 NP_001317098 NP_005972 NP_080258 Location (UCSC) Chr 12: 57.74 – 57.75 Mb Chr 10: 126.9 – 126.91 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tetraspanin-31 is a protein that in humans is encoded by the TSPAN31 gene. ^[5]

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is thought to be involved in growth-related cellular processes. This gene is associated with tumorigenesis and osteosarcoma. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000135452 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000006736 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: TSPAN31 tetraspanin 31".

Further reading

• Wright MD, Tomlinson MG (1995). "The ins and outs of the transmembrane 4 superfamily". Immunol. Today. 15 (12): 588–94. doi:10.1016/0167-5699(94)90222-4. PMID   7531445.
• Meltzer PS, Jankowski SA, Dal Cin P, et al. (1992). "Identification and cloning of a novel amplified DNA sequence in human malignant fibrous histiocytoma derived from a region of chromosome 12 frequently rearranged in soft tissue tumors". Cell Growth Differ. 2 (10): 495–501. PMID   1661131.
• Jankowski SA, De Jong P, Meltzer PS (1995). "Genomic structure of SAS, a member of the transmembrane 4 superfamily amplified in human sarcomas". Genomics. 25 (2): 501–6. doi:10.1016/0888-7543(95)80051-M. PMID   7789984.
• Jankowski SA, Mitchell DS, Smith SH, et al. (1994). "SAS, a gene amplified in human sarcomas, encodes a new member of the transmembrane 4 superfamily of proteins". Oncogene. 9 (4): 1205–11. PMID   8134123.
• Elkahloun AG, Krizman DB, Wang Z, et al. (1997). "Transcript mapping in a 46-kb sequenced region at the core of 12q13.3 amplification in human cancers". Genomics. 42 (2): 295–301. doi:10.1006/geno.1997.4727. PMID   9192850.
• Wunder JS, Eppert K, Burrow SR, et al. (1999). "Co-amplification and overexpression of CDK4, SAS and MDM2 occurs frequently in human parosteal osteosarcomas". Oncogene. 18 (3): 783–8. doi: 10.1038/sj.onc.1202346 . PMID   9989829.
• Ragazzini P, Gamberi G, Benassi MS, et al. (1999). "Analysis of SAS gene and CDK4 and MDM2 proteins in low-grade osteosarcoma". Cancer Detect. Prev. 23 (2): 129–36. doi:10.1046/j.1525-1500.1999.09907.x. PMID   10101594.
• Suzuki Y, Tsunoda T, Sese J, et al. (2001). "Identification and Characterization of the Potential Promoter Regions of 1031 Kinds of Human Genes". Genome Res. 11 (5): 677–84. doi:10.1101/gr.gr-1640r. PMC   311086 . PMID   11337467.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Ragazzini P, Gamberi G, Pazzaglia L, et al. (2004). "Amplification of CDK4, MDM2, SAS and GLI genes in leiomyosarcoma, alveolar and embryonal rhabdomyosarcoma". Histol. Histopathol. 19 (2): 401–11. PMID   15024701.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.