Membrane-spanning 4A genes are members of the CD20-like family. The MS4A genes are usually organized in a single genomic clusters in mammals, suggestive of gene duplication events. [1] MS4A genes encode a class of four-transmembrane spanning proteins. MS4A genes have been described to act as a specific kind of olfactory receptor in the necklace olfactory sensory neurons in mice (Mus musculus). [2]
In human ( Homo sapiens ) the members of this family include:
Olfactory receptors (ORs), also known as odorant receptors, are expressed in the cell membranes of olfactory receptor neurons and are responsible for the detection of odorants which give rise to the sense of smell. Activated olfactory receptors trigger nerve impulses which transmit information about odor to the brain. These receptors are members of the class A rhodopsin-like family of G protein-coupled receptors (GPCRs). The olfactory receptors form a multigene family consisting of around 800 genes in humans and 1400 genes in mice.
B-lymphocyte antigen CD20 or CD20 is expressed on the surface of all B-cells beginning at the pro-B phase and progressively increasing in concentration until maturity.
Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.
Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene.
CD151 molecule, also known as CD151, is a human gene.
Olfactory receptor 1D2 is a protein that in humans is encoded by the OR1D2 gene.
CD82, or KAI1, is a human protein encoded by the CD82 gene.
CD7 is a protein that in humans is encoded by the CD7 gene.
Transcription factor COE1 is a protein that in humans is encoded by the EBF1 gene. EBF1 stands for Early B-Cell Factor 1.
NKG2-C type II integral membrane protein or NKG2C is a protein that in humans is encoded by the KLRC2 gene. It is also known as or cluster of differentiation 159c (CD159c).
T-cell surface glycoprotein CD1e, membrane-associated is a protein that in humans is encoded by the CD1E gene.
Olfactory receptor 3A1 is a protein that in humans is encoded by the OR3A1 gene.
Olfactory receptor 1E1 is a protein that in humans is encoded by the OR1E1 gene.
Olfactory receptor 52A1 is a protein that in humans is encoded by the OR52A1 gene.
Olfactory receptor 1J2 is a protein that in humans is encoded by the OR1J2 gene.
Olfactory receptor 13H1 is a protein that in humans is encoded by the OR13H1 gene.
Olfactory receptor 3A4 is a protein that in humans is encoded by the OR3A4 gene.
Membrane-spanning 4-domains subfamily A member 7 is a protein that in humans is encoded by the MS4A7 gene.
High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene.
Membrane-spanning 4-domains subfamily A member 3 is a protein that in humans is encoded by the MS4A3 gene.