MS4A2

MS4A2
Identifiers
Aliases	MS4A2 , APY, ATOPY, FCER1B, FCERI, IGEL, IGER, IGHER, MS4A1, membrane spanning 4-domains A2
External IDs	OMIM: 147138; MGI: 95495; HomoloGene: 112; GeneCards: MS4A2; OMA:MS4A2 - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q12.1 Start 60,088,261 bp [1] End 60,098,467 bp [1]
Gene location (Mouse) Chr. Chromosome 19 (mouse) [2] Band 19 A|19 8.46 cM Start 11,592,887 bp [2] End 11,601,083 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in gonad gallbladder testicle rectum monocyte right coronary artery gastric mucosa smooth muscle tissue upper lobe of left lung skin of hip Top expressed in renal corpuscle skin of external ear granulocyte dermis otic vesicle embryo blood epithelium of stomach lip bone marrow More reference expression data BioGPS More reference expression data
Gene ontology Molecular function IgE binding Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane external side of plasma membrane Fc-epsilon receptor I complex Biological process Fc-epsilon receptor signaling pathway cell surface receptor signaling pathway inflammatory response immune response signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2206 14126 Ensembl ENSG00000149534 ENSMUSG00000024680 UniProt Q01362 P20490 RefSeq (mRNA) NM_000139 NM_001142303 NM_001256916 NM_001276328 NM_001276329 NM_001276330 NM_013516 RefSeq (protein) NP_000130 NP_001243845 NP_001263257 NP_001263258 NP_001263259 NP_038544 Location (UCSC) Chr 11: 60.09 – 60.1 Mb Chr 19: 11.59 – 11.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

High affinity immunoglobulin epsilon receptor subunit beta is a protein that in humans is encoded by the MS4A2 gene. ^{[5] [6]}

Function

The allergic response involves the binding of allergen to receptor-bound IgE followed by cell activation and the release of mediators responsible for the manifestations of allergy. The IgE-receptor, a tetramer composed of an alpha, beta, and 2 disulfide-linked gamma chains, is found on the surface of mast cells and basophils. This gene encodes the beta subunit of the high affinity IgE receptor which is a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. This family member is localized to 11q12, among a cluster of family members. ^[6]

See also

• FcεRI

References

1. GRCh38: Ensembl release 89: ENSG00000149534 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000024680 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Maekawa K, Imagawa N, Tanaka Y, Harada S (Aug 1992). "Determination of the sequence coding for the beta subunit of the human high-affinity IgE receptor". FEBS Lett. 302 (2): 161–5. Bibcode:1992FEBSL.302..161M. doi: 10.1016/0014-5793(92)80430-O . PMID   1386024. S2CID   44791683.
6. "Entrez Gene: MS4A2 membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for; beta polypeptide)".

Further reading

• Jouvin MH, Numerof RP, Kinet JP (1995). "Signal transduction through the conserved motifs of the high affinity IgE receptor Fc epsilon RI". Semin. Immunol. 7 (1): 29–35. doi:10.1016/1044-5323(95)90005-5. PMID   7612892.
• Wilson BS, Pfeiffer JR, Oliver JM (2003). "FcepsilonRI signaling observed from the inside of the mast cell membrane". Mol. Immunol. 38 (16–18): 1259–68. doi:10.1016/S0161-5890(02)00073-1. PMID   12217393.
• Kraft S, Rana S, Jouvin MH, Kinet JP (2004). "The role of the FcepsilonRI beta-chain in allergic diseases". Int. Arch. Allergy Immunol. 135 (1): 62–72. doi:10.1159/000080231. PMID   15316148. S2CID   83898946.
• Bieber T, de la Salle H, Wollenberg A, et al. (1992). "Human epidermal Langerhans cells express the high affinity receptor for immunoglobulin E (Fc epsilon RI)". J. Exp. Med. 175 (5): 1285–90. doi:10.1084/jem.175.5.1285. PMC   2119213 . PMID   1533242.
• Küster H, Zhang L, Brini AT, et al. (1992). "The gene and cDNA for the human high affinity immunoglobulin E receptor beta chain and expression of the complete human receptor". J. Biol. Chem. 267 (18): 12782–7. doi: 10.1016/S0021-9258(18)42344-7 . PMID   1535625.
• Le Coniat M, Kinet JP, Berger R (1990). "The human genes for the alpha and gamma subunits of the mast cell receptor for immunoglobulin E are located on human chromosome band 1q23". Immunogenetics. 32 (3): 183–6. doi:10.1007/BF02114971. PMID   2146219. S2CID   23874749.
• Tedder TF, Streuli M, Schlossman SF, Saito H (1988). "Isolation and structure of a cDNA encoding the B1 (CD20) cell-surface antigen of human B lymphocytes". Proc. Natl. Acad. Sci. U.S.A. 85 (1): 208–12. Bibcode:1988PNAS...85..208T. doi: 10.1073/pnas.85.1.208 . PMC   279513 . PMID   2448768.
• Paolini R, Renard V, Vivier E, et al. (1995). "Different roles for the Fc epsilon RI gamma chain as a function of the receptor context". J. Exp. Med. 181 (1): 247–55. doi:10.1084/jem.181.1.247. PMC   2191817 . PMID   7528770.
• Shirakawa T, Li A, Dubowitz M, et al. (1994). "Association between atopy and variants of the beta subunit of the high-affinity immunoglobulin E receptor". Nat. Genet. 7 (2): 125–9. doi:10.1038/ng0694-125. PMID   7920628. S2CID   24026689.
• Kihara H, Siraganian RP (1994). "Src homology 2 domains of Syk and Lyn bind to tyrosine-phosphorylated subunits of the high affinity IgE receptor". J. Biol. Chem. 269 (35): 22427–32. doi: 10.1016/S0021-9258(17)31807-0 . PMID   8071371.
• Sandford AJ, Shirakawa T, Moffatt MF, et al. (1993). "Localisation of atopy and beta subunit of high-affinity IgE receptor (Fc epsilon RI) on chromosome 11q". Lancet. 341 (8841): 332–4. doi:10.1016/0140-6736(93)90136-5. PMID   8094113. S2CID   54428682.
• Szepetowski P, Gaudray P (1994). "FCER1B, a candidate gene for atopy, is located in 11q13 between CD20 and TCN1". Genomics. 19 (2): 399–400. doi:10.1006/geno.1994.1083. PMID   8188278.
• Daniels SE, Bhattacharrya S, James A, et al. (1996). "A genome-wide search for quantitative trait loci underlying asthma". Nature. 383 (6597): 247–50. Bibcode:1996Natur.383..247D. doi:10.1038/383247a0. PMID   8805698. S2CID   22256638.
• Hill MR, Cookson WO (1997). "A new variant of the beta subunit of the high-affinity receptor for immunoglobulin E (Fc epsilon RI-beta E237G): associations with measures of atopy and bronchial hyper-responsiveness". Hum. Mol. Genet. 5 (7): 959–62. doi: 10.1093/hmg/5.7.959 . PMID   8817330.
• Shirakawa T, Mao XQ, Sasaki S, et al. (1997). "Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population". Hum. Mol. Genet. 5 (8): 1129–30. doi: 10.1093/hmg/5.8.1129 . PMID   8842731.
• Shirakawa T, Mao XQ, Sasaki S, et al. (1997). "Association between atopic asthma and a coding variant of Fc epsilon RI beta in a Japanese population". Hum. Mol. Genet. 5 (12): 2068. PMID   8968765.
• Hendricks-Taylor LR, Motto DG, Zhang J, et al. (1997). "SLP-76 is a substrate of the high affinity IgE receptor-stimulated protein tyrosine kinases in rat basophilic leukemia cells". J. Biol. Chem. 272 (2): 1363–7. doi: 10.1074/jbc.272.2.1363 . PMID   8995445.
• Kanzaki M, Lindorfer MA, Garrison JC, Kojima I (1997). "Activation of the calcium-permeable cation channel CD20 by alpha subunits of the Gi protein". J. Biol. Chem. 272 (23): 14733–9. doi: 10.1074/jbc.272.23.14733 . PMID   9169438.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.