TSPAN8 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | TSPAN8 , CO-029, TM4SF3, tetraspanin 8 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 600769 MGI: 2384918 HomoloGene: 20968 GeneCards: TSPAN8 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene. [5] [6]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [6]
Overall survival of ovarian cancer patients was effectively predicted by TSPAN8. [7]
Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. These and other integrin beta 1 complexes have been historically known as very late activation (VLA) antigens.
Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.
CD9 is a gene encoding a protein that is a member of the transmembrane 4 superfamily also known as the tetraspanin family. It is a cell surface glycoprotein that consists of four transmembrane regions and has two extracellular loops that contain disulfide bonds which are conserved throughout the tetraspanin family. Also containing distinct palmitoylation sites that allows CD9 to interact with lipids and other proteins.
Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.
Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene.
CD63 antigen is a protein that, in humans, is encoded by the CD63 gene. CD63 is mainly associated with membranes of intracellular vesicles, although cell surface expression may be induced.
CD151 molecule, also known as CD151, is a human gene.
Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.
CD81 molecule, also known as CD81, is a protein which in humans is encoded by the CD81 gene. It is also known as 26 kDa cell surface protein, TAPA-1, and Tetraspanin-28 (Tspan-28).
CD82, or KAI1, is a human protein encoded by the CD82 gene.
Tetraspanin-7 is a protein that in humans is encoded by the TSPAN7 gene.
Uroplakin-1b (UP1b), is a protein which in humans is encoded by the UPK1B gene.
Uroplakin-1a (UP1a) is a protein that in humans is encoded by the UPK1A gene.
Tetraspanin-13 is a protein that in humans is encoded by the TSPAN13 gene.
Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.
Tetraspanin-6 is a protein that in humans is encoded by the TSPAN6 gene.
Tetraspanin-3 is a protein that in humans is encoded by the TSPAN3 gene.
Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.
Tetraspanin-2 is a protein that in humans is encoded by the TSPAN2 gene.
Tetraspanin-12 (Tspan-12) also known as tetraspan NET-2 (NET2) or transmembrane 4 superfamily member 12 (TM4SF12) is a tetraspanin protein that in humans is encoded by the TSPAN12 gene. Tetraspanin-12 is found in the membrane of a variety of cells. It has an unusually long C-terminal intracellular tail of approximately 60 amino acids.