TSPAN8

Last updated
TSPAN8
Identifiers
Aliases TSPAN8 , CO-029, TM4SF3, tetraspanin 8
External IDs OMIM: 600769; MGI: 2384918; HomoloGene: 20968; GeneCards: TSPAN8; OMA:TSPAN8 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_004616
NM_001369760

NM_001168679
NM_001168680
NM_146010

RefSeq (protein)

NP_004607
NP_001356689

NP_001162150
NP_001162151
NP_666122

Location (UCSC) Chr 12: 71.13 – 71.44 Mb Chr 10: 115.65 – 115.69 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene. [5] [6]

Contents

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [6]

Clinical significance

Overall survival of ovarian cancer patients was effectively predicted by TSPAN8. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000127324 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034127 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ (September 1990). "Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens". Proceedings of the National Academy of Sciences of the United States of America. 87 (17): 6833–7. Bibcode:1990PNAS...87.6833S. doi: 10.1073/pnas.87.17.6833 . PMC   54632 . PMID   2395876.
  6. 1 2 "Entrez Gene: TSPAN8 tetraspanin 8".
  7. Fekete T, Rásó E, Pete I, Tegze B, Liko I, Munkácsy G, Sipos N, Rigó J, Györffy B (July 2012). "Meta-analysis of gene expression profiles associated with histological classification and survival in 829 ovarian cancer samples" (PDF). International Journal of Cancer. 131 (1): 95–105. doi: 10.1002/ijc.26364 . PMID   21858809. S2CID   205944534.

Further reading