TSPAN8

TSPAN8
Identifiers
Aliases	TSPAN8 , CO-029, TM4SF3, tetraspanin 8
External IDs	OMIM: 600769 MGI: 2384918 HomoloGene: 20968 GeneCards: TSPAN8
Gene location (Human)
Chr.	Chromosome 12 (human)
End	71,441,898 bp
Gene location (Mouse)
Chr.	Chromosome 10 (mouse)
End	115,685,798 bp
RNA expression pattern
	Top expressed in
	jejunal mucosa; ; rectum; ; duodenum; ; pancreatic ductal cell; ; bronchial epithelial cell; ; gallbladder; ; pylorus; ; spinal ganglia; ; appendix; ; islet of Langerhans;
	Top expressed in
	seminal vesicula; ; mucous cell of stomach; ; Epithelium of stomach; ; left colon; ; pyloric antrum; ; crypt of lieberkuhn of small intestine; ; Paneth cell; ; right lung lobe; ; ileum; ; left lung lobe;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	integrin binding ; protein binding ;
Cellular component	integral component of membrane ; integral component of plasma membrane ; extracellular exosome ; membrane ; cell surface ;
Biological process	cell surface receptor signaling pathway ; negative regulation of blood coagulation ; spermatogenesis ; regulation of gene expression ;
	Sources:Amigo / QuickGO
Orthologs
	7103
	216350
	ENSG00000127324
	ENSMUSG00000034127
	P19075
	Q8R3G9
	NM_004616 ; NM_001369760
	NM_001168679 ; NM_001168680 ; NM_146010
	NP_004607 ; NP_001356689
	NP_001162150 ; NP_001162151 ; NP_666122
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated December 01, 2022

Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene.^[5]^[6]

Function

The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene.^[6]

Clinical significance

Overall survival of ovarian cancer patients was effectively predicted by TSPAN8.^[7]

Related Research Articles

Integrin beta-1 (ITGB1), also known as CD29, is a cell surface receptor that in humans is encoded by the ITGB1 gene. This integrin associates with integrin alpha 1 and integrin alpha 2 to form integrin complexes which function as collagen receptors. It also forms dimers with integrin alpha 3 to form integrin receptors for netrin 1 and reelin. These and other integrin beta 1 complexes have been historically known as very late activation (VLA) antigens.

Integrin alpha-3 is a protein that in humans is encoded by the ITGA3 gene. ITGA3 is an integrin alpha subunit. Together with beta-1 subunit, it makes up half of the α3β1 integrin duplex that plays a role in neural migration and corticogenesis, acted upon by such factors as netrin-1 and reelin.

CD9 is a gene encoding a protein that is a member of the transmembrane 4 superfamily also known as the tetraspanin family. It is a cell surface glycoprotein that consists of four transmembrane regions and has two extracellular loops that contain disulfide bonds which are conserved throughout the tetraspanin family. Also containing distinct palmitoylation sites that allows CD9 to interact with lipids and other proteins.

Leukocyte antigen CD37 is a protein that in humans is encoded by the CD37 gene.

Leukocyte surface antigen CD53 is a protein that in humans is encoded by the CD53 gene.

CD63 antigen is a protein that, in humans, is encoded by the CD63 gene. CD63 is mainly associated with membranes of intracellular vesicles, although cell surface expression may be induced.

CD151 molecule, also known as CD151, is a human gene.

Integrin alpha-6 is a protein that in humans is encoded by the ITGA6 gene.

CD81 molecule, also known as CD81, is a protein which in humans is encoded by the CD81 gene. It is also known as 26 kDa cell surface protein, TAPA-1, and Tetraspanin-28 (Tspan-28).

CD82, or KAI1, is a human protein encoded by the CD82 gene.

Tetraspanin-7 is a protein that in humans is encoded by the TSPAN7 gene.

Uroplakin-1b (UP1b), is a protein which in humans is encoded by the UPK1B gene.

Uroplakin-1a (UP1a) is a protein that in humans is encoded by the UPK1A gene.

Tetraspanin-13 is a protein that in humans is encoded by the TSPAN13 gene.

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.

Tetraspanin-6 is a protein that in humans is encoded by the TSPAN6 gene.

Tetraspanin-3 is a protein that in humans is encoded by the TSPAN3 gene.

Transmembrane 4 L6 family member 5 is a protein that in humans is encoded by the TM4SF5 gene.

Tetraspanin-2 is a protein that in humans is encoded by the TSPAN2 gene.

Tetraspanin-12 (Tspan-12) also known as tetraspan NET-2 (NET2) or transmembrane 4 superfamily member 12 (TM4SF12) is a tetraspanin protein that in humans is encoded by the TSPAN12 gene. Tetraspanin-12 is found in the membrane of a variety of cells. It has an unusually long C-terminal intracellular tail of approximately 60 amino acids.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000127324 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034127 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ (September 1990). "Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens". Proceedings of the National Academy of Sciences of the United States of America. 87 (17): 6833–7. Bibcode:1990PNAS...87.6833S. doi: 10.1073/pnas.87.17.6833 . PMC 54632 . PMID 2395876.
1 2 "Entrez Gene: TSPAN8 tetraspanin 8".
↑ Fekete T, Rásó E, Pete I, Tegze B, Liko I, Munkácsy G, Sipos N, Rigó J, Györffy B (July 2012). "Meta-analysis of gene expression profiles associated with histological classification and survival in 829 ovarian cancer samples" (PDF). International Journal of Cancer. 131 (1): 95–105. doi: 10.1002/ijc.26364 . PMID 21858809. S2CID 205944534.

Berditchevski F (December 2001). "Complexes of tetraspanins with integrins: more than meets the eye". Journal of Cell Science. 114 (Pt 23): 4143–51. doi:10.1242/jcs.114.23.4143. PMID 11739647.
Maruyama K, Sugano S (January 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Gwynn B, Eicher EM, Peters LL (July 1996). "Genetic localization of Cd63, a member of the transmembrane 4 superfamily, reveals two distinct loci in the mouse genome". Genomics. 35 (2): 389–91. doi:10.1006/geno.1996.0375. PMID 8661157.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (October 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Serru V, Le Naour F, Billard M, Azorsa DO, Lanza F, Boucheix C, Rubinstein E (May 1999). "Selective tetraspan-integrin complexes (CD81/alpha4beta1, CD151/alpha3beta1, CD151/alpha6beta1) under conditions disrupting tetraspan interactions". The Biochemical Journal. 340 ( Pt 1) (Pt 1): 103–11. doi:10.1042/0264-6021:3400103. PMC 1220227 . PMID 10229664.
Kanetaka K, Sakamoto M, Yamamoto Y, Yamasaki S, Lanza F, Kanematsu T, Hirohashi S (November 2001). "Overexpression of tetraspanin CO-029 in hepatocellular carcinoma". Journal of Hepatology. 35 (5): 637–42. doi:10.1016/S0168-8278(01)00183-0. PMID 11690710.
Shackel NA, McGuinness PH, Abbott CA, Gorrell MD, McCaughan GW (September 2003). "Novel differential gene expression in human cirrhosis detected by suppression subtractive hybridization". Hepatology. 38 (3): 577–88. doi: 10.1053/jhep.2003.50376 . PMID 12939584. S2CID 46013740.
Kuhn S, Koch M, Nübel T, Ladwein M, Antolovic D, Klingbeil P, Hildebrand D, Moldenhauer G, Langbein L, Franke WW, Weitz J, Zöller M (June 2007). "A complex of EpCAM, claudin-7, CD44 variant isoforms, and tetraspanins promotes colorectal cancer progression". Molecular Cancer Research. 5 (6): 553–67. doi: 10.1158/1541-7786.MCR-06-0384 . PMID 17579117.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000127324 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000034127 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2395876-5] Szala S, Kasai Y, Steplewski Z, Rodeck U, Koprowski H, Linnenbach AJ (September 1990). "Molecular cloning of cDNA for the human tumor-associated antigen CO-029 and identification of related transmembrane antigens". Proceedings of the National Academy of Sciences of the United States of America. 87 (17): 6833–7. Bibcode:1990PNAS...87.6833S. doi: 10.1073/pnas.87.17.6833 . PMC 54632 . PMID 2395876.

[entrez-6] 1 2 "Entrez Gene: TSPAN8 tetraspanin 8".

[7] Fekete T, Rásó E, Pete I, Tegze B, Liko I, Munkácsy G, Sipos N, Rigó J, Györffy B (July 2012). "Meta-analysis of gene expression profiles associated with histological classification and survival in 829 ovarian cancer samples" (PDF). International Journal of Cancer. 131 (1): 95–105. doi: 10.1002/ijc.26364 . PMID 21858809. S2CID 205944534.

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v t e Protein: cell membrane proteins (other than Cell surface receptor, enzymes, and cytoskeleton)
Arrestin	SAG ARRB1 ARRB2 ARR3
Membrane-spanning 4A	MS4A1 MS4A2 MS4A3 MS4A4A MS4A4E MS4A5 MS4A6A MS4A6E MS4A7 MS4A8B MS4A9 MS4A10 MS4A12 MS4A13 MS4A14 MS4A15 MS4A18
Myelin	Myelin basic protein PMP2 Myelin proteolipid protein PLP1 Myelin oligodendrocyte glycoprotein Myelin-associated glycoprotein Myelin protein zero
Pulmonary surfactant	Pulmonary surfactant-associated protein B Pulmonary surfactant-associated protein C
Tetraspanin	TSPAN1 TSPAN2 TSPAN3 TSPAN4 TSPAN5 TSPAN6 TSPAN7 TSPAN8 TSPAN9 TSPAN10 TSPAN11 TSPAN12 TSPAN13 TSPAN14 TSPAN15 TSPAN16 TSPAN17 TSPAN18 TSPAN19 TSPAN20 TSPAN21 TSPAN22 TSPAN23 TSPAN24 TSPAN25 TSPAN26 TSPAN27 TSPAN28 TSPAN29 TSPAN30 TSPAN31 TSPAN32 TSPAN33 TSPAN34
Other/ungrouped	Calnexin LDL-receptor-related protein-associated protein Neurofibromin 2 Presenilin PSEN1 PSEN2 HFE Phospholipid transfer proteins Dysferlin STRC OTOF
see also other cell membrane protein disorders

TSPAN8

Contents

Function

Clinical significance

Related Research Articles

References

Further reading