TSPAN8 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | TSPAN8 , CO-029, TM4SF3, tetraspanin 8 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 600769; MGI: 2384918; HomoloGene: 20968; GeneCards: TSPAN8; OMA:TSPAN8 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Tetraspanin-8 is a protein that in humans is encoded by the TSPAN8 gene. [5] [6]
The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. This encoded protein is a cell surface glycoprotein that is known to complex with integrins. This gene is expressed in different carcinomas. The use of alternate polyadenylation sites has been found for this gene. [6]
Overall survival of ovarian cancer patients was effectively predicted by TSPAN8. [7]