FUT3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Aliases | FUT3 , CD174, FT3B, FucT-III, LE, Les, Fucosyltransferase 3, fucosyltransferase 3 (Lewis blood group) | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | HomoloGene: 128031 GeneCards: FUT3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Galactoside 3(4)-L-fucosyltransferase is an enzyme that in humans is encoded by the FUT3 gene. [3] [4] [5]
The Lewis histo-blood group system comprises a set of fucosylated glycosphingolipids that are synthesized by exocrine epithelial cells and circulate in body fluids. The glycosphingolipids function in embryogenesis, tissue differentiation, tumor metastasis, inflammation, and bacterial adhesion. They are secondarily absorbed to red blood cells giving rise to their Lewis phenotype. This gene is a member of the fucosyltransferase family, which catalyzes the addition of fucose to precursor polysaccharides in the last step of Lewis antigen biosynthesis. It encodes an enzyme with alpha(1,3)-fucosyltransferase and alpha(1,4)-fucosyltransferase activities. Mutations in this gene are responsible for the majority of Lewis antigen-negative phenotypes. Multiple alternatively spliced variants, encoding the same protein, have been found for this gene. [5]
The Lewis antigen system is a human blood group system. It is based upon two genes on chromosome 19: FUT3, or Lewis gene; and FUT2, or Secretor gene. Both genes are expressed in glandular epithelia. FUT2 has a dominant allele which codes for an enzyme and a recessive allele which does not produce a functional enzyme. Similarly, FUT3 has a functional dominant allele (Le) and a non-functional recessive allele (le).
In enzymology, a 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase is an enzyme that catalyzes the chemical reaction
In enzymology, a 4-galactosyl-N-acetylglucosaminide 3-alpha-L-fucosyltransferase is an enzyme that catalyzes the chemical reaction
Galactoside 2-alpha-L-fucosyltransferase 2 is an enzyme that in humans is encoded by the FUT2 gene. It affects the secretor status of ABO antigens.
Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT7 gene.
Galactoside 2-alpha-L-fucosyltransferase 1 is an enzyme that in humans is encoded by the FUT1 gene.
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the GCNT1 gene.
Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT6 gene.
Alpha-(1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene.
Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT9 gene.
UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2 is an enzyme that in humans is encoded by the B3GNT2 gene.
ST3 beta-galactoside alpha-2,3-sialyltransferase 3, also known as ST3GAL3, is a protein which in humans is encoded by the ST3GAL3 gene.
Beta-1,4-galactosyltransferase 7 also known as galactosyltransferase I is an enzyme that in humans is encoded by the B4GALT7 gene. Galactosyltransferase I catalyzes the synthesis of the glycosaminoglycan-protein linkage in proteoglycans. Proteoglycans in turn are structural components of the extracellular matrix that is found between cells in connective tissues.
Prefoldin subunit 5 is a protein that in humans is encoded by the PFDN5 gene.
Lactosylceramide 4-alpha-galactosyltransferase is an enzyme that in humans is encoded by the A4GALT gene.
Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 1 is an enzyme that in humans is encoded by the ST6GALNAC1 gene. This enzyme adds a N-Acetylneuraminic acid to an O-linked N-Acetylgalactosamine (GalNAc) on a peptide/proteins with an α2-6 linkage to produce the sialyl-Tn antigen. It has been shown that the enzyme prefers Thr over Ser containing GalNAc residues.
Histo-blood group ABO system transferase is an enzyme with glycosyltransferase activity, which is encoded by the ABO gene in humans. It is ubiquitously expressed in many tissues and cell types. ABO determines the ABO blood group of an individual by modifying the oligosaccharides on cell surface glycoproteins. Variations in the sequence of the protein between individuals determine the type of modification and the blood group. The ABO gene also contains one of 27 SNPs associated with increased risk of coronary artery disease.
Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT5 gene.
Chondroitin sulfate N-acetylgalactosaminyltransferase 1 is an enzyme that in humans is encoded by the CSGALNACT1 gene.
Fucosyltransferase 4 , also known as FUT4, is an enzyme which in humans is encoded by the FUT4 gene.