B3GAT3

Last updated
B3GAT3
Protein B3GAT3 PDB 1fgg.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases B3GAT3 , GLCATI, glcUAT-I, JDSCD, beta-1,3-glucuronyltransferase 3
External IDs OMIM: 606374; MGI: 1919977; HomoloGene: 56554; GeneCards: B3GAT3; OMA:B3GAT3 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001288721
NM_001288722
NM_001288723
NM_012200

NM_024256

RefSeq (protein)

NP_001275650
NP_001275651
NP_001275652
NP_036332

NP_077218

Location (UCSC) Chr 11: 62.62 – 62.62 Mb Chr 19: 8.9 – 8.9 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Beta-1,3-Glucuronyltransferase 3 is an enzyme that in humans is encoded by the B3GAT3 gene. [5] [6]

Contents

The protein encoded by this gene is a member of the glucuronyltransferase gene family, enzymes that exhibit strict acceptor specificity, recognizing nonreducing terminal sugars and their anomeric linkages. This gene product catalyzes the formation of the glycosaminoglycan-protein linkage by way of a glucuronyl transfer reaction in the final step of the biosynthesis of the linkage region of proteoglycans. [6]

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000149541 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000071649 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Kitagawa H, Tone Y, Tamura J, Neumann KW, Ogawa T, Oka S, Kawasaki T, Sugahara K (Apr 1998). "Molecular cloning and expression of glucuronyltransferase I involved in the biosynthesis of the glycosaminoglycan-protein linkage region of proteoglycans". J Biol Chem. 273 (12): 6615–8. doi: 10.1074/jbc.273.12.6615 . PMID   9506957.
  6. 1 2 "Entrez Gene: B3GAT3 beta-1,3-glucuronyltransferase 3 (glucuronosyltransferase I)".

Further reading