Pseudomonas exotoxin

Last updated
Exotoxin A
1aer.jpg
Exotoxin A dimer, Pseudomonas aeruginosa
Identifiers
Organism Pseudomonas aeruginosa
Symboleta
Orthologs OMA: entry
UniProt P11439
Other data
EC number 2.4.2.36
Search for
Structures Swiss-model
Domains InterPro

The Pseudomonas exotoxin (or exotoxin A) is an exotoxin produced by Pseudomonas aeruginosa . [1] Vibrio cholerae produces a similar protein called the Cholix toxin ( Q5EK40 ). [2]

It inhibits elongation factor-2. It does so by ADP-ribosylation of EF2 using NAD+. This then causes the elongation of polypeptides to cease. This mechanism is similar to that of diphtheria toxin. [3]

It has been investigated as a treatment for hepatitis B [4] and cancer. [5]

References

  1. ↑ Yates SP, Taylor PL, Jørgensen R, Ferraris D, Zhang J, Andersen GR, Merrill AR (February 2005). "Structure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa". The Biochemical Journal. 385 (Pt 3): 667–75. doi:10.1042/BJ20041480. PMC   1134741 . PMID   15458385.
  2. ↑ Jørgensen R, Purdy AE, Fieldhouse RJ, Kimber MS, Bartlett DH, Merrill AR (April 2008). "Cholix toxin, a novel ADP-ribosylating factor from Vibrio cholerae". The Journal of Biological Chemistry. 283 (16): 10671–8. doi: 10.1074/jbc.M710008200 . PMID   18276581.
  3. ↑ Yates SP, Merrill AR (May 2004). "Elucidation of eukaryotic elongation factor-2 contact sites within the catalytic domain of Pseudomonas aeruginosa exotoxin A". The Biochemical Journal. 379 (Pt 3): 563–72. doi:10.1042/BJ20031731. PMC   1224111 . PMID   14733615.
  4. ↑ Hafkemeyer P, Brinkmann U, Brinkmann E, Pastan I, Blum HE, Baumert TF (May 2008). "Pseudomonas exotoxin antisense RNA selectively kills hepatitis B virus infected cells". World Journal of Gastroenterology. 14 (18): 2810–7. doi: 10.3748/wjg.14.2810 . PMC   2710720 . PMID   18473403.
  5. ↑ Stuckey DW, Hingtgen SD, Karakas N, Rich BE, Shah K (February 2015). "Engineering toxin-resistant therapeutic stem cells to treat brain tumors". Stem Cells. 33 (2): 589–600. doi:10.1002/stem.1874. PMC   4305025 . PMID   25346520.
This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.