UGT1A8

UGT1A8
Identifiers
Aliases	UGT1A8 , UDPGT, UDPGT 1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H, UDP glucuronosyltransferase family 1 member A8, UGT1-01, UGT-1A, UGT1.1, UGT1A, hUG-BR1, UGT1, GNT1, UGT1A1, UDPGT 1-1
External IDs	OMIM: 606433 MGI: 3576092 HomoloGene: 133281 GeneCards: UGT1A8
Gene location (Human) Chr. Chromosome 2 (human) [1] Band 2q37.1 Start 233,617,633 bp [1] End 233,773,300 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1|1 D Start 87,998,522 bp [2] End 88,146,719 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in rectum gallbladder duodenum urinary bladder right lobe of liver islet of Langerhans appendix renal cortex thymus kidney Top expressed in hepatobiliary system liver duodenum colon renal cortex proximal tubule stomach kidney ileum jejunum More reference expression data BioGPS n/a
Gene ontology Molecular function transferase activity enzyme inhibitor activity retinoic acid binding hexosyltransferase activity protein homodimerization activity glycosyltransferase activity glucuronosyltransferase activity fatty acid binding steroid binding protein heterodimerization activity enzyme binding UDP-glycosyltransferase activity Cellular component integral component of membrane endoplasmic reticulum membrane membrane intracellular membrane-bounded organelle endoplasmic reticulum Biological process steroid metabolic process coumarin metabolic process negative regulation of steroid metabolic process retinoic acid metabolic process negative regulation of cellular glucuronidation fatty acid metabolic process cellular glucuronidation flavonoid glucuronidation xenobiotic glucuronidation flavone metabolic process metabolism negative regulation of glucuronosyltransferase activity negative regulation of fatty acid metabolic process negative regulation of catalytic activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 54576 394434 Ensembl ENSG00000242366 ENSMUSG00000090175 UniProt Q9HAW9 Q62452 RefSeq (mRNA) NM_019076 NM_201644 RefSeq (protein) NP_061949 NP_964006 Location (UCSC) Chr 2: 233.62 – 233.77 Mb Chr 1: 88 – 88.15 Mb PubMed search [3] [4]
Wikidata
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UDP-glucuronosyltransferase 1-8 is an enzyme that in humans is encoded by the UGT1A8 gene. ^{[5] [6] [7]}

Function

This gene encodes a UDP-glucuronosyltransferase, an enzyme of the glucuronidation pathway that transforms small lipophilic molecules, such as steroids, bilirubin, hormones, and drugs, into water-soluble, excretable metabolites. This gene is part of a complex locus that encodes several UDP-glucuronosyltransferases. The locus includes thirteen unique alternate first exons followed by four common exons. Four of the alternate first exons are considered pseudogenes. Each of the remaining nine 5′ exons may be spliced to the four common exons, resulting in nine proteins with different N-termini and identical C-termini. Each first exon encodes the substrate binding site, and is regulated by its own promoter. The enzyme encoded by this gene has glucuronidase activity with many substrates including coumarins, phenols, anthraquinones, flavones, and some opioids. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000242366 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000090175 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (Mar 1992). "A novel complex locus UGT1 encodes human bilirubin, phenol, and other UDP-glucuronosyltransferase isozymes with identical carboxyl termini". J Biol Chem. 267 (5): 3257–61. doi: 10.1016/S0021-9258(19)50724-4 . PMID   1339448.
6. Huang YH, Galijatovic A, Nguyen N, Geske D, Beaton D, Green J, Green M, Peters WH, Tukey RH (June 2002). "Identification and functional characterization of UDP-glucuronosyltransferases UGT1A8*1, UGT1A8*2 and UGT1A8*3". Pharmacogenetics. 12 (4): 287–97. doi:10.1097/00008571-200206000-00004. PMID   12042666.
7. "Entrez Gene: UGT1A8 UDP glucuronosyltransferase 1 family, polypeptide A8".

This article incorporates text from the United States National Library of Medicine, which is in the public domain.