FUT4

fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific)
Identifiers
Symbol	FUT4
Alt. symbols	CD15, FCT3A, ELFT, SSEA-1, LeX
NCBI gene	2526
HGNC	4015
OMIM	104230
RefSeq	NM_002033
UniProt	P22083
Other data
EC number	2.4.1.152
Locus	Chr. 11 q21
Search for Structures Swiss-model Domains InterPro

Fucosyltransferase 4 (alpha (1,3) fucosyltransferase, myeloid-specific), also known as FUT4, is an enzyme which in humans is encoded by the FUT4 gene. ^{[1] [2] [3]}

Function

The product of this gene transfers fucose to N-acetyllactosamine polysaccharides to generate fucosylated carbohydrate structures. It catalyzes the synthesis of the non-sialylated antigen, Lewis x (CD15). ^{[4] [5]}

References

1. Goelz SE, Hession C, Goff D, Griffiths B, Tizard R, Newman B, Chi-Rosso G, Lobb R (December 1990). "ELFT: a gene that directs the expression of an ELAM-1 ligand". Cell. 63 (6): 1349–56. doi:10.1016/0092-8674(90)90430-M. PMID   1702034. S2CID   905332.
2. Couillin P, Mollicone R, Grisard MC, Gibaud A, Ravisé N, Feingold J, Oriol R (1991). "Chromosome 11q localization of one of the three expected genes for the human alpha-3-fucosyltransferases, by somatic hybridization". Cytogenet. Cell Genet. 56 (2): 108–11. doi:10.1159/000133061. PMID   1672847.
3. Reguigne I, James MR, Richard CW, Mollicone R, Seawright A, Lowe JB, Oriol R, Couillin P (1994). "The gene encoding myeloid alpha-3-fucosyl-transferase (FUT4) is located between D1 1S388 and D11S919 on 11q21". Cytogenet. Cell Genet. 66 (2): 104–6. doi:10.1159/000133677. PMID   8287679.
4. "Entrez Gene: FUT4".
5. Nakayama F, Nishihara S, Iwasaki H, Kudo T, Okubo R, Kaneko M, Nakamura M, Karube M, Sasaki K, Narimatsu H (May 2001). "CD15 expression in mature granulocytes is determined by alpha 1,3-fucosyltransferase IX, but in promyelocytes and monocytes by alpha 1,3-fucosyltransferase IV". J. Biol. Chem. 276 (19): 16100–6. doi: 10.1074/jbc.M007272200 . PMID   11278338.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.