FUT6

FUT6
Identifiers
Aliases	FUT6 , FCT3A, FT1A, Fuc-TVI, FucT-VI, fucosyltransferase 6
External IDs	OMIM: 136836 HomoloGene: 34780 GeneCards: FUT6
Gene location (Human)
Chr.	Chromosome 19 (human)
End	5,839,722 bp
RNA expression pattern
	Top expressed in
	olfactory bulb; ; pancreatic ductal cell; ; amniotic fluid; ; trachea; ; cavity of mouth; ; kidney; ; kidney tubule; ; body of tongue; ; superior surface of tongue; ; jejunal mucosa;
	n/a
	More reference expression data
	; ;
	More reference expression data
Gene ontology
Molecular function	transferase activity ; alpha-(1->3)-fucosyltransferase activity ; 3-galactosyl-N-acetylglucosaminide 4-alpha-L-fucosyltransferase activity ; glycosyltransferase activity ; fucosyltransferase activity ;
Cellular component	integral component of membrane ; Golgi cisterna membrane ; Golgi apparatus ; extracellular exosome ; membrane ; Golgi membrane ;
Biological process	protein glycosylation ; L-fucose catabolic process ; fucosylation ; ceramide metabolic process ;
	Sources:Amigo / QuickGO
Orthologs
	2528
	n/a
	ENSG00000156413
	n/a
	P51993
	n/a
NM_000150 ; NM_001040701 ; NM_001369502 ; NM_001369504 ; NM_001369505 ;
	NM_001381955 ; NM_001381956 ; NM_001381957 ; NM_001381958 ; NM_001381959
	n/a
NP_000141 ; NP_001035791 ; NP_001356431 ; NP_001356433 ; NP_001356434 ;
	NP_001368884 ; NP_001368885 ; NP_001368886 ; NP_001368887 ; NP_001368888
	n/a
	Wikidata
View/Edit Human

Last updated September 30, 2022

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT6 gene.^[3]^[4]^[5]

The alpha-1,3-fucosyltransferases constitute a large family of glycosyltransferases with a high degree of homology. The enzymes of this family comprise 3 main activity patterns called myeloid, plasma, and Lewis, based on their capacity to transfer alpha-L-fucose to distinct oligosaccharide acceptors, their sensitivity to N-ethylmaleimide inhibition, their cation requirements, and their tissue-specific expression patterns. The different categories of alpha-1,3-fucosyltransferases are sequentially expressed during embryo-fetal development.[supplied by OMIM]^[5]

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Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase is an enzyme that in humans is encoded by the GCNT1 gene.

Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase is an enzyme that in humans is encoded by the ST8SIA1 gene.

Alpha-(1,6)-fucosyltransferase is an enzyme that in humans is encoded by the FUT8 gene.

Neutral alpha-glucosidase AB is an enzyme that in humans is encoded by the GANAB gene.

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT9 gene.

CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase is an enzyme that in humans is encoded by the ST3GAL4 gene.

Caveolin-2 is a protein that in humans is encoded by the CAV2 gene.

Alpha-(1,3)-fucosyltransferase is an enzyme that in humans is encoded by the FUT5 gene.

Alpha-N-acetylgalactosaminide alpha-2,6-sialyltransferase 6 is an enzyme that in humans is encoded by the ST6GALNAC6 gene.

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Fucosyltransferase 4 is a protein that in humans is encoded by the FUT4 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000156413 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Koszdin KL, Bowen BR (Oct 1992). "The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand". Biochem Biophys Res Commun. 187 (1): 152–7. doi:10.1016/S0006-291X(05)81472-X. PMID 1520296.
↑ McCurley RS, Recinos A III, Olsen AS, Gingrich JC, Szczepaniak D, Cameron HS, Krauss R, Weston BW (Jul 1995). "Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21". Genomics. 26 (1): 142–6. doi:10.1016/0888-7543(95)80094-3. PMID 7782074.
1 2 "Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)".

Weston BW, Smith PL, Kelly RJ, Lowe JB (1992). "Molecular cloning of a fourth member of a human alpha (1,3)fucosyltransferase gene family. Multiple homologous sequences that determine expression of the Lewis x, sialyl Lewis x, and difucosyl sialyl Lewis x epitopes". J. Biol. Chem. 267 (34): 24575–84. doi: 10.1016/S0021-9258(18)35803-4 . PMID 1339443.
Cameron HS, Szczepaniak D, Weston BW (1995). "Expression of human chromosome 19p alpha(1,3)-fucosyltransferase genes in normal tissues. Alternative splicing, polyadenylation, and isoforms". J. Biol. Chem. 270 (34): 20112–22. doi: 10.1074/jbc.270.34.20112 . PMID 7650030.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Mollicone R, Reguigne I, Fletcher A, et al. (1994). "Molecular basis for plasma alpha(1,3)-fucosyltransferase gene deficiency (FUT6)". J. Biol. Chem. 269 (17): 12662–71. doi: 10.1016/S0021-9258(18)99927-8 . PMID 8175676.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Borsig L, Imbach T, Höchli M, Berger EG (2000). "alpha1,3Fucosyltransferase VI is expressed in HepG2 cells and codistributed with beta1,4galactosyltransferase I in the golgi apparatus and monensin-induced swollen vesicles". Glycobiology. 9 (11): 1273–80. doi: 10.1093/glycob/9.11.1273 . PMID 10536043.
Schnyder-Candrian S, Borsig L, Moser R, Berger EG (2000). "Localization of alpha 1,3-fucosyltransferase VI in Weibel-Palade bodies of human endothelial cells". Proc. Natl. Acad. Sci. U.S.A. 97 (15): 8369–74. Bibcode:2000PNAS...97.8369S. doi: 10.1073/pnas.97.15.8369 . PMC 26954 . PMID 10900002.
Kamińska J, Musielak M, Nowicka A, et al. (2001). "Neutrophils promote the release of alpha-6-fucosyltransferase from blood platelets through the action of cathepsin G and elastase". Biochimie. 83 (8): 739–42. doi:10.1016/S0300-9084(01)01306-2. PMID 11530205.
Roos C, Kolmer M, Mattila P, Renkonen R (2002). "Composition of Drosophila melanogaster proteome involved in fucosylated glycan metabolism". J. Biol. Chem. 277 (5): 3168–75. doi: 10.1074/jbc.M107927200 . PMID 11698403.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Kanoh A, Ota M, Narimatsu H, Irimura T (2003). "Expression levels of FUT6 gene transfected into human colon carcinoma cells switch two sialyl-Lewis X-related carbohydrate antigens with distinct properties in cell adhesion". Biochem. Biophys. Res. Commun. 303 (3): 896–901. doi:10.1016/S0006-291X(03)00420-0. PMID 12670495.
Martinez-Duncker I, Michalski JC, Bauvy C, et al. (2004). "Activity and tissue distribution of splice variants of alpha6-fucosyltransferase in human embryogenesis". Glycobiology. 14 (1): 13–25. doi: 10.1093/glycob/cwh006 . PMID 14514715.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID 14702039.
Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC 1356129 . PMID 16344560.
Higai K, Miyazaki N, Azuma Y, Matsumoto K (2007). "Interleukin-1beta induces sialyl Lewis X on hepatocellular carcinoma HuH-7 cells via enhanced expression of ST3Gal IV and FUT VI gene". FEBS Lett. 580 (26): 6069–75. doi: 10.1016/j.febslet.2006.09.073 . PMID 17054948. S2CID 9731951.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000156413 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid1520296-3] Koszdin KL, Bowen BR (Oct 1992). "The cloning and expression of a human alpha-1,3 fucosyltransferase capable of forming the E-selectin ligand". Biochem Biophys Res Commun. 187 (1): 152–7. doi:10.1016/S0006-291X(05)81472-X. PMID 1520296.

[pmid7782074-4] McCurley RS, Recinos A III, Olsen AS, Gingrich JC, Szczepaniak D, Cameron HS, Krauss R, Weston BW (Jul 1995). "Physical maps of human alpha (1,3)fucosyltransferase genes FUT3-FUT6 on chromosomes 19p13.3 and 11q21". Genomics. 26 (1): 142–6. doi:10.1016/0888-7543(95)80094-3. PMID 7782074.

[entrez-5] 1 2 "Entrez Gene: FUT6 fucosyltransferase 6 (alpha (1,3) fucosyltransferase)".

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FUT6

Related Research Articles

References

Further reading