UGT2A2

UGT2A2
Identifiers
Aliases	UGT2A2 , UDP glucuronosyltransferase family 2 member A2, UDPGT 2A2
External IDs	MGI: 3576095 HomoloGene: 115736 GeneCards: UGT2A2
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q13.3 Start 69,588,417 bp [1] End 69,639,642 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 E1 Start 87,607,349 bp [2] End 87,630,119 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver anterior pituitary kidney renal cortex skin of abdomen vagina myometrium intestine Top expressed in respiratory epithelium olfactory epithelium duodenum hepatobiliary system liver jejunum olfactory bulb kidney integument skin More reference expression data BioGPS n/a
Gene ontology Molecular function glycosyltransferase activity transferase activity glucuronosyltransferase activity hexosyltransferase activity UDP-glycosyltransferase activity Cellular component integral component of membrane intracellular membrane-bounded organelle membrane Biological process sensory perception of smell detection of chemical stimulus cellular glucuronidation response to stimulus metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 574537 552899 Ensembl ENSG00000271271 ENSMUSG00000029268 UniProt Q9Y4X1 Q6PDD0 RefSeq (mRNA) NM_001301233 NM_001105677 NM_001024148 RefSeq (protein) NP_001099147 NP_001288162 NP_001239203 NP_001239204 NP_001288168 NP_006789 NP_001019319 Location (UCSC) Chr 4: 69.59 – 69.64 Mb Chr 5: 87.61 – 87.63 Mb PubMed search [3] [4]
Wikidata
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UDP glucuronosyltransferase 2 family, polypeptide A2, also known as UGT2A2, is an enzyme that in humans is encoded by the UGT2A2 gene. ^{[5] [6]}

Function

The olfactory neuroepithelium, which lines the posterior nasal cavity, is exposed to a wide range of odorants and airborne toxic compounds. Odorants, which are mostly small lipophilic molecules, enter the mucus flow and reach the odorant receptors on sensory neurons. Odorant sensing is generally a transient process, requiring an effective signal termination, which could be provided by biotransformation of the odorant in the epithelial supporting cells. Xenobiotic-metabolizing enzymes in the olfactory epithelium have been suggested to catalyze inactivation and facilitate elimination of odorants. ^[5] UGT2A1 and UGT2A2 were recently implicated as having a role in the loss of smell symptom associated with COVID-19. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000271271 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029268 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: UDP glucuronosyltransferase 2 family, polypeptide A2".
6. Mackenzie PI, Bock KW, Burchell B, Guillemette C, Ikushiro S, Iyanagi T, Miners JO, Owens IS, Nebert DW (October 2005). "Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily". Pharmacogenet. Genomics. 15 (10): 677–85. doi:10.1097/01.fpc.0000173483.13689.56. PMID   16141793.
7. Shelton, Janie F.; Shastri, Anjali J.; Aslibekyan, Stella; Auton, Adam; Auton, Adam (2021). "The UGT2A1/UGT2A2 locus is associated with COVID-19-related anosmia | medRxiv". medRxiv   10.1101/2021.05.28.21257993v1 .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.