UGT2A1

UGT2A1
Identifiers
Aliases	UGT2A1 , UDPGT2A1, UDP glucuronosyltransferase family 2 member A1 complex locus
External IDs	OMIM: 604716 MGI: 2149905 HomoloGene: 136808 GeneCards: UGT2A1
Gene location (Human) Chr. Chromosome 4 (human) [1] Band 4q13.3 Start 69,588,417 bp [1] End 69,653,249 bp [1]
Gene location (Mouse) Chr. Chromosome 5 (mouse) [2] Band 5|5 E1 Start 87,607,349 bp [2] End 87,638,730 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in liver pituitary gland right lobe of liver anterior pituitary sural nerve kidney kidney renal cortex skin of abdomen right lung Top expressed in respiratory epithelium olfactory epithelium olfactory bulb exocrine gland hepatobiliary system liver More reference expression data BioGPS n/a
Gene ontology Molecular function glycosyltransferase activity transferase activity glucuronosyltransferase activity hexosyltransferase activity UDP-glycosyltransferase activity Cellular component integral component of membrane intracellular membrane-bounded organelle membrane Biological process sensory perception of smell detection of chemical stimulus cellular glucuronidation response to stimulus metabolism Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10941 94215 Ensembl ENSG00000173610 ENSMUSG00000106677 UniProt Q9Y4X1 Q80X89 RefSeq (mRNA) NM_001252274 NM_001252275 NM_001301239 NM_006798 NM_001389565 NM_053184 RefSeq (protein) NP_001099147 NP_001288162 NP_001239203 NP_001239204 NP_001288168 NP_006789 NP_444414 Location (UCSC) Chr 4: 69.59 – 69.65 Mb Chr 5: 87.61 – 87.64 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

UDP glucuronosyltransferase 2 family, polypeptide B1, also known as UGT2B1, is an enzyme that in humans is encoded by the UGT2B1 gene. ^{[5] [6]}

Function

The olfactory neuroepithelium, which lines the posterior nasal cavity, is exposed to a wide range of odorants and airborne toxic compounds. Odorants, which are mostly small lipophilic molecules, enter the mucus flow and reach the odorant receptors on sensory neurons. Odorant sensing is generally a transient process, requiring an effective signal termination, which could be provided by biotransformation of the odorant in the epithelial supporting cells. Xenobiotic-metabolizing enzymes in the olfactory epithelium have been suggested to catalyze inactivation and facilitate elimination of odorants. ^[6] UGT2A1 and UGT2A2 were recently implicated as having a role in the loss of smell associated with COVID-19. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000173610 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000106677 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Jedlitschky G, Cassidy AJ, Sales M, Pratt N, Burchell B (June 1999). "Cloning and characterization of a novel human olfactory UDP-glucuronosyltransferase". Biochem. J. 340 (3): 837–43. doi:10.1042/0264-6021:3400837. PMC   1220318 . PMID   10359671.
6. "Entrez Gene: UGT2B1 UDP glucuronosyltransferase 2 family, polypeptide B1".
7. Shelton, Janie F.; Shastri, Anjali J.; Aslibekyan, Stella; Auton, Adam; Auton, Adam (2021). "The UGT2A1/UGT2A2 locus is associated with COVID-19-related anosmia | medRxiv". medRxiv   10.1101/2021.05.28.21257993v1 .

Further reading

• Iida A, Saito S, Sekine A, et al. (2002). "Catalog of 86 single-nucleotide polymorphisms (SNPs) in three uridine diphosphate glycosyltransferase genes: UGT2A1, UGT2B15, and UGT8". J. Hum. Genet. 47 (10): 505–10. doi: 10.1007/s100380200075 . PMID   12376738.
• Tukey RH, Strassburg CP (2001). "Genetic multiplicity of the human UDP-glucuronosyltransferases and regulation in the gastrointestinal tract". Mol. Pharmacol. 59 (3): 405–14. doi:10.1124/mol.59.3.405. PMID   11179432. S2CID   21500183.
• Strassburg CP, Kneip S, Topp J, et al. (2000). "Polymorphic gene regulation and interindividual variation of UDP-glucuronosyltransferase activity in human small intestine". J. Biol. Chem. 275 (46): 36164–71. doi: 10.1074/jbc.M002180200 . PMID   10748067.
• Heydel J, Leclerc S, Bernard P, et al. (2001). "Rat olfactory bulb and epithelium UDP-glucuronosyltransferase 2A1 (UGT2A1) expression: in situ mRNA localization and quantitative analysis". Brain Res. Mol. Brain Res. 90 (1): 83–92. doi:10.1016/S0169-328X(01)00080-8. PMID   11376859.
• Saito A, Kawamoto M, Kamatani N (2009). "Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects". J. Hum. Genet. 54 (6): 317–23. doi: 10.1038/jhg.2009.31 . PMID   19343046.
• Ross CJ, Katzov-Eckert H, Dubé MP, et al. (2009). "Genetic variants in TPMT and COMT are associated with hearing loss in children receiving cisplatin chemotherapy". Nat. Genet. 41 (12): 1345–9. doi:10.1038/ng.478. PMID   19898482. S2CID   21293339.
• Mackenzie PI, Bock KW, Burchell B, et al. (2005). "Nomenclature update for the mammalian UDP glycosyltransferase (UGT) gene superfamily". Pharmacogenet. Genomics. 15 (10): 677–85. doi:10.1097/01.fpc.0000173483.13689.56. PMID   16141793.

This article incorporates text from the United States National Library of Medicine, which is in the public domain.