HAS3

HAS3
Identifiers
Aliases	HAS3 , hyaluronan synthase 3
External IDs	OMIM: 602428 MGI: 109599 HomoloGene: 68461 GeneCards: HAS3
Gene location (Human) Chr. Chromosome 16 (human) [1] Band 16q22.1 Start 69,105,653 bp [1] End 69,118,719 bp [1]
Gene location (Mouse) Chr. Chromosome 8 (mouse) [2] Band 8 D3|8 53.28 cM Start 106,870,242 bp [2] End 106,884,566 bp [2]
Gene ontology Molecular function • transferase activity • glycosyltransferase activity • hyaluronan synthase activity • GO:0001948 protein binding • identical protein binding Cellular component • cytoplasm • integral component of membrane • plasma membrane • hyaluranon cable • integral component of plasma membrane • membrane Biological process • positive regulation of transcription, DNA-templated • cell adhesion • hyaluronan biosynthetic process • extracellular matrix assembly • positive regulation of hyaluranon cable assembly • extracellular polysaccharide biosynthetic process • carbohydrate metabolic process Sources:Amigo / QuickGO
Orthologs
Species	Human	Mouse
Entrez	3038	15118
Ensembl	ENSG00000103044	ENSMUSG00000031910
UniProt	O00219	O08650
RefSeq (mRNA)	NM_001199280 NM_005329 NM_138612	NM_008217 NM_001331048
RefSeq (protein)	NP_001186209 NP_005320 NP_619515	NP_001317977 NP_032243
Location (UCSC)	Chr 16: 69.11 – 69.12 Mb	Chr 8: 106.87 – 106.88 Mb
PubMed search	[3]	[4]
Wikidata
View/Edit Human View/Edit Mouse

Hyaluronan synthase 3 is an enzyme that in humans is encoded by the HAS3 gene. ^{[5] [6] [7]}

The protein encoded by this gene is involved in the synthesis of the unbranched glycosaminoglycan hyaluronan, or hyaluronic acid, which is a major constituent of the extracellular matrix. This gene is a member of the NODC/HAS gene family. Compared to the proteins encoded by other members of this gene family, this protein appears to be more of a regulator of hyaluronan synthesis. Two transcript variants encoding different isoforms have been found for this gene. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000103044 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000031910 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Spicer AP, Seldin MF, Olsen AS, Brown N, Wells DE, Doggett NA, Itano N, Kimata K, Inazawa J, McDonald JA (Jul 1997). "Chromosomal localization of the human and mouse hyaluronan synthase genes". Genomics. 41 (3): 493–7. doi:10.1006/geno.1997.4696. PMID   9169154.
6. Spicer AP, Olson JS, McDonald JA (May 1997). "Molecular cloning and characterization of a cDNA encoding the third putative mammalian hyaluronan synthase". J Biol Chem. 272 (14): 8957–61. doi: 10.1074/jbc.272.14.8957 . PMID   9083017.
7. "Entrez Gene: HAS3 hyaluronan synthase 3".

Further reading

• Jacobson A, Brinck J, Briskin MJ, et al. (2000). "Expression of human hyaluronan synthases in response to external stimuli". Biochem. J. 348. Pt 1 (1): 29–35. doi:10.1042/0264-6021:3480029. PMC   1221032 . PMID   10794710.
• Simpson MA, Reiland J, Burger SR, et al. (2001). "Hyaluronan synthase elevation in metastatic prostate carcinoma cells correlates with hyaluronan surface retention, a prerequisite for rapid adhesion to bone marrow endothelial cells". J. Biol. Chem. 276 (21): 17949–57. doi: 10.1074/jbc.M010064200 . PMID   11278609.
• Kuroda K, Utani A, Hamasaki Y, Shinkai H (2001). "Up-regulation of putative hyaluronan synthase mRNA by basic fibroblast growth factor and insulin-like growth factor-1 in human skin fibroblasts". J. Dermatol. Sci. 26 (2): 156–60. doi:10.1016/S0923-1811(00)00155-9. PMID   11378333.
• Liu N, Gao F, Han Z, et al. (2001). "Hyaluronan synthase 3 overexpression promotes the growth of TSU prostate cancer cells". Cancer Res. 61 (13): 5207–14. PMID   11431361.
• Simpson MA, Wilson CM, Furcht LT, et al. (2002). "Manipulation of hyaluronan synthase expression in prostate adenocarcinoma cells alters pericellular matrix retention and adhesion to bone marrow endothelial cells". J. Biol. Chem. 277 (12): 10050–7. doi: 10.1074/jbc.M110069200 . PMID   11790779.
• Sayo T, Sugiyama Y, Takahashi Y, et al. (2002). "Hyaluronan synthase 3 regulates hyaluronan synthesis in cultured human keratinocytes". J. Invest. Dermatol. 118 (1): 43–8. doi: 10.1046/j.0022-202x.2001.01613.x . PMID   11851874.
• Chagnon P, Michaud J, Mitchell G, et al. (2003). "A missense mutation (R565W) in cirhin (FLJ14728) in North American Indian childhood cirrhosis". Am. J. Hum. Genet. 71 (6): 1443–9. doi:10.1086/344580. PMC   378590 . PMID   12417987.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Bullard KM, Kim HR, Wheeler MA, et al. (2004). "Hyaluronan synthase-3 is upregulated in metastatic colon carcinoma cells and manipulation of expression alters matrix retention and cellular growth". Int. J. Cancer. 107 (5): 739–46. doi: 10.1002/ijc.11475 . PMID   14566823. S2CID   24405794.
• Suzuki K, Yamamoto T, Usui T, et al. (2004). "Expression of hyaluronan synthase in intraocular proliferative diseases: regulation of expression in human vascular endothelial cells by transforming growth factor-beta". Jpn. J. Ophthalmol. 47 (6): 557–64. doi:10.1016/j.jjo.2003.09.001. PMID   14636845.
• Grskovic B, Pollaschek C, Mueller MM, Stuhlmeier KM (2006). "Expression of hyaluronan synthase genes in umbilical cord blood stem/progenitor cells". Biochim. Biophys. Acta. 1760 (6): 890–5. doi:10.1016/j.bbagen.2006.02.002. PMID   16564133.
• Campo GM, Avenoso A, Campo S, et al. (2007). "TNF-alpha, IFN-gamma, and IL-1beta modulate hyaluronan synthase expression in human skin fibroblasts: synergistic effect by concomital treatment with FeSO4 plus ascorbate". Mol. Cell. Biochem. 292 (1–2): 169–78. doi:10.1007/s11010-006-9230-7. PMID   16786194. S2CID   37598580.