CD300A

CD300A
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2Q87
Identifiers
Aliases	CD300A , CLM-8, CMRF-35-H9, CMRF-35H, CMRF35-H, CMRF35-H9, CMRF35H, CMRF35H9, IGSF12, IRC1, IRC1/IRC2, IRC2, IRp60, CD300a molecule
External IDs	OMIM: 606790 MGI: 2443411 HomoloGene: 48514 GeneCards: CD300A
Gene location (Human) Chr. Chromosome 17 (human) [1] Band 17q25.1 Start 74,466,399 bp [1] End 74,484,794 bp [1]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood monocyte spleen bone marrow bone marrow cells amniotic fluid appendix periodontal fiber lymph node spongy bone n/a More reference expression data BioGPS More reference expression data
Gene ontology Molecular function signaling receptor activity phosphatidylethanolamine binding phosphatidylserine binding protein binding Cellular component integral component of membrane extracellular exosome membrane plasma membrane tertiary granule membrane ficolin-1-rich granule membrane Biological process regulation of T cell receptor signaling pathway immune system process negative regulation of eosinophil migration positive regulation of phosphoprotein phosphatase activity negative regulation of neutrophil activation negative regulation of eosinophil activation regulation of immune response negative regulation of fibroblast proliferation negative regulation of MAP kinase activity negative regulation of mast cell degranulation negative regulation of mast cell activation involved in immune response cell adhesion negative regulation of NK T cell activation negative regulation of B cell receptor signaling pathway negative regulation of activation of Janus kinase activity negative regulation of phagocytosis, engulfment negative regulation of B cell proliferation signal transduction negative regulation of MyD88-dependent toll-like receptor signaling pathway neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 11314 217303 Ensembl ENSG00000167851 n/a UniProt Q9UGN4 Q6SJQ0 RefSeq (mRNA) NM_001256841 NM_007261 NM_001330456 NM_001330457 NM_170758 NM_001347654 NM_001359812 RefSeq (protein) NP_001243770 NP_001317385 NP_001317386 NP_009192 NP_001334583 NP_739564 NP_001346741 Location (UCSC) Chr 17: 74.47 – 74.48 Mb n/a PubMed search [2] [3]
Wikidata
View/Edit Human View/Edit Mouse

CD300A (Cluster of Differentiation 300A) is a human gene. ^[4]

The CMRF35 antigen (CMRF35A; MIM 606786), which was identified by reactivity with a monoclonal antibody, is present on monocytes, neutrophils, and some T and B lymphocytes. CMRF35H is recognized by the same antibody and is distinct from CMRF35 (Green et al., 1998).[supplied by OMIM] ^[4]

See also

• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000167851 - Ensembl, May 2017
2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
3. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Entrez Gene: CD300A CD300a molecule".

Further reading

• Clark GJ, Fitzpatrick S, Kuo B, et al. (2003). "CMRF-35A, CMRF-35H: potential new CD". J. Biol. Regul. Homeost. Agents. 16 (3): 233–5. PMID   12456026.
• Alvarez Y, Tang X, Coligan JE, Borrego F (2007). "The CD300a (IRp60) inhibitory receptor is rapidly up-regulated on human neutrophils in response to inflammatory stimuli and modulates CD32a (FcgammaRIIa) mediated signaling". Mol. Immunol. 45 (1): 253–8. doi:10.1016/j.molimm.2007.05.006. PMC   2000843 . PMID   17588661.
• Bachelet I, Munitz A, Moretta A, et al. (2006). "The inhibitory receptor IRp60 (CD300a) is expressed and functional on human mast cells". J. Immunol. 175 (12): 7989–95. doi: 10.4049/jimmunol.175.12.7989 . PMID   16339535.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark GJ, Green BJ, Hart DN (2000). "The CMRF-35H gene structure predicts for an independently expressed member of an ITIM/ITAM pair of molecules localized to human chromosome 17". Tissue Antigens. 55 (2): 101–9. doi:10.1034/j.1399-0039.2000.550201.x. PMID   10746781.
• Cantoni C, Bottino C, Augugliaro R, et al. (1999). "Molecular and functional characterization of IRp60, a member of the immunoglobulin superfamily that functions as an inhibitory receptor in human NK cells". Eur. J. Immunol. 29 (10): 3148–59. doi:10.1002/(SICI)1521-4141(199910)29:10<3148::AID-IMMU3148>3.0.CO;2-L. PMID   10540326. S2CID   8828216.
• Green BJ, Clark GJ, Hart DN (1998). "The CMRF-35 mAb recognizes a second leukocyte membrane molecule with a domain similar to the poly Ig receptor". Int. Immunol. 10 (7): 891–9. doi:10.1093/intimm/10.7.891. PMID   9701027.
• Jackson DG, Hart DN, Starling G, Bell JI (1992). "Molecular cloning of a novel member of the immunoglobulin gene superfamily homologous to the polymeric immunoglobulin receptor". Eur. J. Immunol. 22 (5): 1157–63. doi:10.1002/eji.1830220508. PMID   1349532. S2CID   23437463.

External links

• CD300A+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
• CD300a, Bernholtz - The Possible End to Asthma - The Future of Things article
• Human CD300A genome location and CD300A gene details page in the UCSC Genome Browser .
• Overview of all the structural information available in the PDB for UniProt : Q9UGN4 (Human CMRF35-like molecule 8 (CD300A)) at the PDBe-KB .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.