FCGR3B

FCGR3B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1E4J, 1E4K, 1FNL, 1T83, 1T89
Identifiers
Aliases	FCGR3B , CD16, CD16b, FCG3, FCGR3, FCR-10, FCRIII, FCRIIIb, Fc fragment of IgG receptor IIIb, CD16A, FCGR3A, Fc gamma receptor IIIb, CD16-I
External IDs	OMIM: 610665; MGI: 2179523; HomoloGene: 477; GeneCards: FCGR3B; OMA:FCGR3B - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q23.3 Start 161,623,196 bp [1] End 161,631,963 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 H3|1 78.53 cM Start 170,846,489 bp [2] End 170,857,330 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in blood periodontal fiber trabecular bone granulocyte spleen bone marrow palpebral conjunctiva bone marrow cells germinal epithelium right lung Top expressed in granulocyte ileum jejunum spleen liver ovary secondary oocyte bone marrow adrenal gland embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function IgG binding Cellular component anchored component of membrane extracellular exosome membrane extracellular region plasma membrane secretory granule membrane Biological process immune response C-terminal protein lipidation neutrophil degranulation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2215 246256 Ensembl ENSG00000162747 ENSMUSG00000059089 UniProt O75015 A0A0B4J1G0 RefSeq (mRNA) NM_001271037 NM_000570 NM_001244753 NM_001271035 NM_001271036 NM_144559 NM_180961 RefSeq (protein) NP_000561 NP_001231682 NP_001257964 NP_001257965 NP_001257966 NP_653142 Location (UCSC) Chr 1: 161.62 – 161.63 Mb Chr 1: 170.85 – 170.86 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

FCGR3B (Fc fragment of IgG, low affinity IIIb, receptor), also known as CD16b (Cluster of Differentiation 16b), is a human gene. ^[5]

Clinical relevance

Mutations and copy-number variations in this gene have been associated to clinical cases of glomerulonephritis. ^[6]

See also

• CD16
• Cluster of differentiation

References

1. GRCh38: Ensembl release 89: ENSG00000162747 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000059089 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: FCGR3B Fc fragment of IgG, low affinity IIIb, receptor (CD16b)".
6. Aitman TJ, Dong R, Vyse TJ, Norsworthy PJ, Johnson MD, Smith J, Mangion J, Roberton-Lowe C, Marshall AJ, Petretto E, Hodges MD, Bhangal G, Patel SG, Sheehan-Rooney K, Duda M, Cook PR, Evans DJ, Domin J, Flint J, Boyle JJ, Pusey CD, Cook HT (Feb 2006). "Copy number polymorphism in Fcgr3 predisposes to glomerulonephritis in rats and humans". Nature. 439 (7078): 851–5. Bibcode:2006Natur.439..851A. doi:10.1038/nature04489. PMID   16482158. S2CID   4421459.

Further reading

• Qiu WQ, de Bruin D, Brownstein BH, Pearse R, Ravetch JV (May 1990). "Organization of the human and mouse low-affinity Fc gamma R genes: duplication and recombination". Science. 248 (4956): 732–5. Bibcode:1990Sci...248..732Q. doi:10.1126/science.2139735. PMID   2139735.
• Peltz GA, Grundy HO, Lebo RV, Yssel H, Barsh GS, Moore KW (Feb 1989). "Human Fc gamma RIII: cloning, expression, and identification of the chromosomal locus of two Fc receptors for IgG". Proceedings of the National Academy of Sciences of the United States of America. 86 (3): 1013–7. Bibcode:1989PNAS...86.1013P. doi: 10.1073/pnas.86.3.1013 . PMC   286611 . PMID   2521732.
• Scallon BJ, Scigliano E, Freedman VH, Miedel MC, Pan YC, Unkeless JC, Kochan JP (Jul 1989). "A human immunoglobulin G receptor exists in both polypeptide-anchored and phosphatidylinositol-glycan-anchored forms". Proceedings of the National Academy of Sciences of the United States of America. 86 (13): 5079–83. Bibcode:1989PNAS...86.5079S. doi: 10.1073/pnas.86.13.5079 . PMC   297560 . PMID   2525780.
• Ravetch JV, Perussia B (Aug 1989). "Alternative membrane forms of Fc gamma RIII(CD16) on human natural killer cells and neutrophils. Cell type-specific expression of two genes that differ in single nucleotide substitutions". The Journal of Experimental Medicine. 170 (2): 481–97. doi:10.1084/jem.170.2.481. PMC   2189395 . PMID   2526846.
• Simmons D, Seed B (Jun 1988). "The Fc gamma receptor of natural killer cells is a phospholipid-linked membrane protein". Nature. 333 (6173): 568–70. Bibcode:1988Natur.333..568S. doi:10.1038/333568a0. PMID   2967436. S2CID   4351255.
• Gessner JE, Grussenmeyer T, Kolanus W, Schmidt RE (Jan 1995). "The human low affinity immunoglobulin G Fc receptor III-A and III-B genes. Molecular characterization of the promoter regions". The Journal of Biological Chemistry. 270 (3): 1350–61. doi: 10.1074/jbc.270.3.1350 . PMID   7836402.
• Gessner JE, Grussenmeyer T, Dumbsky M, Schmidt RE (Nov 1996). "Separate promoters from proximal and medial control regions contribute to the natural killer cell-specific transcription of the human FcgammaRIII-A (CD16-A) receptor gene". The Journal of Biological Chemistry. 271 (48): 30755–64. doi: 10.1074/jbc.271.48.30755 . PMID   8940055.
• Bux J, Stein EL, Bierling P, Fromont P, Clay M, Stroncek D, Santoso S (Feb 1997). "Characterization of a new alloantigen (SH) on the human neutrophil Fc gamma receptor IIIb". Blood. 89 (3): 1027–34. doi: 10.1182/blood.V89.3.1027 . PMID   9028335.
• Zocchi MR, Rubartelli A, Morgavi P, Poggi A (Sep 1998). "HIV-1 Tat inhibits human natural killer cell function by blocking L-type calcium channels". Journal of Immunology. 161 (6): 2938–43. doi:10.4049/jimmunol.161.6.2938. PMID   9743356.
• Sondermann P, Huber R, Oosthuizen V, Jacob U (Jul 2000). "The 3.2-A crystal structure of the human IgG1 Fc fragment-Fc gammaRIII complex". Nature. 406 (6793): 267–73. Bibcode:2000Natur.406..267S. doi:10.1038/35018508. PMID   10917521. S2CID   4306592.
• Zhang Y, Boesen CC, Radaev S, Brooks AG, Fridman WH, Sautes-Fridman C, Sun PD (Sep 2000). "Crystal structure of the extracellular domain of a human Fc gamma RIII". Immunity. 13 (3): 387–95. doi: 10.1016/S1074-7613(00)00038-8 . PMID   11021536.
• Watanabe Y, Shimada E, Fujiwara K, Niihara H, Shimano K, Mitsunaga S, Tadokoro K, Juji T (Sep 2000). "Nucleotide sequence of a new Fc gamma receptor IIIB allele that codes for a neutrophil antigen". Tissue Antigens. 56 (3): 272–5. doi:10.1034/j.1399-0039.2000.560310.x. PMID   11034564.
• Bharadwaj D, Mold C, Markham E, Du Clos TW (Jun 2001). "Serum amyloid P component binds to Fc gamma receptors and opsonizes particles for phagocytosis". Journal of Immunology. 166 (11): 6735–41. doi: 10.4049/jimmunol.166.11.6735 . PMID   11359830.
• Davoine F, Lavigne S, Chakir J, Ferland C, Boulay ME, Laviolette M (Mar 2002). "Expression of FcgammaRIII (CD16) on human peripheral blood eosinophils increases in allergic conditions". The Journal of Allergy and Clinical Immunology. 109 (3): 463–9. doi: 10.1067/mai.2002.121952 . PMID   11897993.
• Fossati G, Moots RJ, Bucknall RC, Edwards SW (May 2002). "Differential role of neutrophil Fcgamma receptor IIIB (CD16) in phagocytosis, bacterial killing, and responses to immune complexes". Arthritis and Rheumatism. 46 (5): 1351–61. doi: 10.1002/art.10230 . PMID   12115243.
• Cauza K, Grassauer A, Hinterhuber G, Horvat R, Rappersberger K, Wolff K, Foedinger D (Nov 2002). "FcgammaRIII expression on cultured human keratinocytes and upregulation by interferon-gamma". The Journal of Investigative Dermatology. 119 (5): 1074–9. doi: 10.1046/j.1523-1747.2002.19527.x . PMID   12445195.
• Siriboonrit U, Tsuchiya N, Sirikong M, Kyogoku C, Bejrachandra S, Suthipinittharm P, Luangtrakool K, Srinak D, Thongpradit R, Fujiwara K, Chandanayingyong D, Tokunaga K (May 2003). "Association of Fcgamma receptor IIb and IIIb polymorphisms with susceptibility to systemic lupus erythematosus in Thais". Tissue Antigens. 61 (5): 374–83. doi:10.1034/j.1399-0039.2003.00047.x. PMID   12753656.
• Breij EC, van der Pol WL, van Winsen L, Jansen MD, Dijkstra CD, van de Winkel JG, Uitdehaag BM (Jul 2003). "No association of Fc gamma RIIa, Fc gamma RIIIa and Fc gamma RIIIb polymorphisms with MS". Journal of Neuroimmunology. 140 (1–2): 210–5. doi:10.1016/S0165-5728(03)00207-8. PMID   12864991. S2CID   53196500.
• Tong Y, Jin J, Yan L, Neppert J, Marget M, Flesch BK (Sep 2003). "FCGR3B gene frequencies and FCGR3 variants in a Chinese population from Zhejiang Province". Annals of Hematology. 82 (9): 574–8. doi:10.1007/s00277-003-0725-y. PMID   12898191. S2CID   21478742.
• Tanaka S, Edberg JC, Chatham W, Fassina G, Kimberly RP (Dec 2003). "Fc gamma RIIIb allele-sensitive release of alpha-defensins: anti-neutrophil cytoplasmic antibody-induced release of chemotaxins". Journal of Immunology. 171 (11): 6090–6. doi: 10.4049/jimmunol.171.11.6090 . PMID   14634123.

External links

• Overview of all the structural information available in the PDB for UniProt : O75015 (Low affinity immunoglobulin gamma Fc region receptor III-B) at the PDBe-KB .

This article incorporates text from the United States National Library of Medicine, which is in the public domain.