LAIR1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
Aliases | LAIR1 , CD305, LAIR-1, leukocyte associated immunoglobulin like receptor 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
External IDs | OMIM: 602992; MGI: 105492; HomoloGene: 48097; GeneCards: LAIR1; OMA:LAIR1 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Leukocyte-associated immunoglobulin-like receptor 1 is a protein that in humans is encoded by the LAIR1 gene. [5] [6] LAIR1 has also been designated as CD305 (cluster of differentiation 305).
The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. [7] Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. [6]
LAIR1 has been shown to interact with PTPN11 [5] [8] and PTPN6. [5] [8] [9] [10] [11]
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ignored (help)This article incorporates text from the United States National Library of Medicine, which is in the public domain.