RGS5

RGS5
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2CRP
Identifiers
Aliases	RGS5 , MST092, MST106, MST129, MSTP032, MSTP092, MSTP106, MSTP129, regulator of G-protein signaling 5, regulator of G protein signaling 5
External IDs	OMIM: 603276; MGI: 1098434; HomoloGene: 2682; GeneCards: RGS5; OMA:RGS5 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1q23.3 Start 163,111,121 bp [1] End 163,321,791 bp [1]
Gene location (Mouse) Chr. Chromosome 1 (mouse) [2] Band 1 H2.3|1 76.84 cM Start 169,483,070 bp [2] End 169,523,382 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Descending thoracic aorta cardia urethra pylorus popliteal artery tibial arteries ascending aorta visceral pleura seminal vesicula right ventricle Top expressed in tunica media of zone of aorta transitional epithelium of urinary bladder body of femur ankle olfactory epithelium digastric muscle sternocleidomastoid muscle temporal muscle triceps brachii muscle medial head of gastrocnemius muscle More reference expression data BioGPS More reference expression data
Gene ontology Molecular function GTPase activator activity GTPase activity Cellular component plasma membrane membrane cytoplasm cytosol Biological process negative regulation of signal transduction regulation of G protein-coupled receptor signaling pathway positive regulation of GTPase activity G protein-coupled receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 8490 19737 Ensembl ENSG00000143248 ENSMUSG00000026678 UniProt O15539 O08850 RefSeq (mRNA) NM_001195303 NM_001254748 NM_001254749 NM_003617 NM_025226 NM_009063 NM_001313705 RefSeq (protein) NP_001182232 NP_001241677 NP_001241678 NP_003608 NP_003608.1 NP_001300634 NP_033089 Location (UCSC) Chr 1: 163.11 – 163.32 Mb Chr 1: 169.48 – 169.52 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Regulator of G-protein signaling 5 is a protein that in humans is encoded by the RGS5 gene. ^{[5] [6]}

The regulator of G protein signaling (RGS) proteins are signal transduction molecules that have structural homology to SST2 of Saccharomyces cerevisiae and EGL-10 of Caenorhabditis elegans. Multiple genes homologous to SST2 are present in higher eukaryotes. RGS proteins are involved in the regulation of heterotrimeric G proteins by acting as GTPase activators. ^[6]

Interactions

RGS5 has been shown to interact with GNAO1, ^{[7] [8]} GNAI2 ^{[7] [8]} and GNAI3. ^{[7] [8]}

References

1. GRCh38: Ensembl release 89: ENSG00000143248 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000026678 – Ensembl, May 2017
3. '"`UNIQ--templatestyles-00000006-QINU`"' "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. '"`UNIQ--templatestyles-00000008-QINU`"' "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Seki N, Sugano S, Suzuki Y, Nakagawara A, Ohira M, Muramatsu M, Saito T, Hori T (October 1998). "Isolation, tissue expression, and chromosomal assignment of human RGS5, a novel G-protein signaling regulator gene". J Hum Genet. 43 (3): 202–5. doi: 10.1007/s100380050071 . PMID   9747037.
6. "Entrez Gene: RGS5 regulator of G-protein signalling 5".
7. Chen, C; Zheng B; Han J; Lin S C (March 1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. 272 (13). UNITED STATES: 8679–85. doi: 10.1074/jbc.272.13.8679 . ISSN   0021-9258. PMID   9079700.
8. Zhou, J; Moroi K; Nishiyama M; Usui H; Seki N; Ishida J; Fukamizu A; Kimura S (February 2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. 68 (13). England: 1457–69. doi:10.1016/S0024-3205(01)00939-0. ISSN   0024-3205. PMID   11253162.

Further reading

• Chen C, Zheng B, Han J, Lin SC (1997). "Characterization of a novel mammalian RGS protein that binds to Galpha proteins and inhibits pheromone signaling in yeast". J. Biol. Chem. 272 (13): 8679–85. doi: 10.1074/jbc.272.13.8679 . PMID   9079700.
• Cismowski MJ, Takesono A, Ma C, et al. (1999). "Genetic screens in yeast to identify mammalian nonreceptor modulators of G-protein signaling". Nat. Biotechnol. 17 (9): 878–83. doi:10.1038/12867. PMID   10471929. S2CID   26981462.
• Adams LD, Geary RL, McManus B, Schwartz SM (2000). "A comparison of aorta and vena cava medial message expression by cDNA array analysis identifies a set of 68 consistently differentially expressed genes, all in aortic media" (PDF). Circ. Res. 87 (7): 623–31. doi: 10.1161/01.res.87.7.623 . PMID   11009569. S2CID   2390642.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Wiemann S, Weil B, Wellenreuther R, et al. (2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
• Zhou J, Moroi K, Nishiyama M, et al. (2001). "Characterization of RGS5 in regulation of G protein-coupled receptor signaling". Life Sci. 68 (13): 1457–69. doi:10.1016/S0024-3205(01)00939-0. PMID   11253162.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Morris DW, Rodgers A, McGhee KA, et al. (2005). "Confirming RGS4 as a susceptibility gene for schizophrenia". Am. J. Med. Genet. B Neuropsychiatr. Genet. 125 (1): 50–3. doi:10.1002/ajmg.b.20109. PMID   14755443. S2CID   45411595.
• Berger M, Bergers G, Arnold B, et al. (2005). "Regulator of G-protein signaling-5 induction in pericytes coincides with active vessel remodeling during neovascularization". Blood. 105 (3): 1094–101. doi: 10.1182/blood-2004-06-2315 . PMID   15459006.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Liang Y, Li C, Guzman VM, et al. (2005). "Identification of a novel alternative splicing variant of RGS5 mRNA in human ocular tissues". FEBS J. 272 (3): 791–9. doi:10.1111/j.1742-4658.2004.04516.x. PMID   15670159. S2CID   13519368.
• Adams LD, Geary RL, Li J, et al. (2006). "Expression profiling identifies smooth muscle cell diversity within human intima and plaque fibrous cap: loss of RGS5 distinguishes the cap". Arterioscler. Thromb. Vasc. Biol. 26 (2): 319–25. doi: 10.1161/01.ATV.0000196647.45718.d6 . PMID   16293795. S2CID   14434603.
• Kimura K, Wakamatsu A, Suzuki Y, et al. (2006). "Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes". Genome Res. 16 (1): 55–65. doi:10.1101/gr.4039406. PMC   1356129 . PMID   16344560.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Rhee KH, Nam KH, Lee WH, et al. (2007). "Expression, purification, and preliminary X-ray crystallographic analysis of the complex of G(alphai3)-RGS5 from human with GDP/Mg2+)/AlF4-". Protein Pept. Lett. 13 (9): 945–9. doi:10.2174/092986606778256225. PMID   17100651.
• Bodenstein J, Sunahara RK, Neubig RR (2007). "N-terminal residues control proteasomal degradation of RGS2, RGS4, and RGS5 in human embryonic kidney 293 cells". Mol. Pharmacol. 71 (4): 1040–50. doi:10.1124/mol.106.029397. PMID   17220356. S2CID   11212754.
• Yang Z, Gaudio S, Song W, et al. (2007). "Evidence for the dimerization of human regulator of G-protein signalling 5 (RGS5)". Cell. Physiol. Biochem. 20 (5): 303–10. doi: 10.1159/000107516 . PMID   17762159.