Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene. [5] [6] [7]
Plexin B1 is a protein of the plexin family that in humans is encoded by the PLXNB1 gene. [5] [6] [7]
Within neural tissues, the plexin family serves as transmembrane receptors for Semaphorins. [8] Outside of neural tissues, Plexin B1 is implicated in the control of cell migration. [9]
PLXNB1 has been shown to interact with ARHGEF12, [10] Rnd1 [11] and ARHGEF11. [10] [11] [12] [13]
Guanine nucleotide exchange factors (GEFs) are proteins or protein domains that activate monomeric GTPases by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP). A variety of unrelated structural domains have been shown to exhibit guanine nucleotide exchange activity. Some GEFs can activate multiple GTPases while others are specific to a single GTPase.
A plexin is a protein which acts as a receptor for semaphorin family signaling proteins. It is classically known for its expression on the surface of axon growth cones and involvement in signal transduction to steer axon growth away from the source of semaphorin. Plexin also has implications in development of other body systems by activating GTPase enzymes to induce a number of intracellular biochemical changes leading to a variety of downstream effects.
The Sema domain is a structural domain of semaphorins, which are a large family of secreted and transmembrane proteins, some of which function as repellent signals during axon guidance. Sema domains also occur in the hepatocyte growth factor receptor, Plexin-A3 and in viral proteins.
A-kinase anchor protein 13 is a protein that in humans, is encoded by the AKAP13 gene. This protein is also called AKAP-Lbc because it encodes the lymphocyte blast crisis (Lbc) oncogene, and ARHGEF13/RhoGEF13 because it contains a guanine nucleotide exchange factor (GEF) domain for the RhoA small GTP-binding protein.
Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene.
Semaphorin-4D (SEMA4D) also known as Cluster of Differentiation 100 (CD100), is a protein of the semaphorin family that in humans is encoded by the SEMA4D gene.
Rho guanine nucleotide exchange factor 11 is a protein that in humans is encoded by the ARHGEF11 gene. This protein is also called RhoGEF11 or PDZ-RhoGEF.
Rho guanine nucleotide exchange factor 12 is a protein that in humans is encoded by the ARHGEF12 gene. This protein is also called RhoGEF12 or Leukemia-associated Rho guanine nucleotide exchange factor (LARG).
Rnd1 is a small signaling G protein, and is a member of the Rnd subgroup of the Rho family of GTPases. It is encoded by the gene RND1.
Plexin-A1 is a protein that in humans is encoded by the PLXNA1 gene.
Plexin-B2 is a protein that in humans is encoded by the PLXNB2 gene.
Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene.
Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene.
Plexin-A2 is a protein that in humans is coded by the PLXNA2 gene.
Semaphorin-4B is a protein that in humans is encoded by the SEMA4B gene.
Plexin-B3 is a protein that in humans is encoded by the PLXNB3 gene.
Plexin-A3 is a protein that in humans is encoded by the PLXNA3 gene.
Guanine nucleotide-binding protein subunit alpha-13 is a protein that in humans is encoded by the GNA13 gene.
Guanine nucleotide-binding protein subunit alpha-12 is a protein that in humans is encoded by the GNA12 gene.
Rap guanine nucleotide exchange factor 6 is a protein that in humans is encoded by the RAPGEF6 gene.
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