ATP11C

ATP11C
Identifiers
Aliases	ATP11C , ATPIG, ATPIQ, ATPase phospholipid transporting 11C, HACXL
External IDs	OMIM: 300516 MGI: 1859661 HomoloGene: 27862 GeneCards: ATP11C
Gene location (Human)
Chr.	X chromosome (human)
End	139,945,276 bp
Gene location (Mouse)
Chr.	X chromosome (mouse)
End	59,636,304 bp
RNA expression pattern
	Top expressed in
	seminal vesicula; ; Achilles tendon; ; liver; ; parietal pleura; ; superficial temporal artery; ; visceral pleura; ; right lobe of liver; ; germinal epithelium; ; lymph node; ; pancreatic epithelial cell;
	Top expressed in
	liver; ; secondary oocyte; ; ganglionic eminence; ; uterus; ; thymus; ; spermatid; ; ovary; ; mesencephalon; ; mirror; ; cerebellar cortex;
	More reference expression data
	n/a
Gene ontology
Molecular function	nucleotide binding ; metal ion binding ; protein binding ; hydrolase activity ; ATP binding ; magnesium ion binding ; ATPase-coupled intramembrane lipid transporter activity ;
Cellular component	integral component of membrane ; recycling endosome ; endoplasmic reticulum membrane ; membrane ; plasma membrane ; lysosomal membrane ; endoplasmic reticulum ; trans-Golgi network ;
Biological process	pre-B cell differentiation ; lipid transport ; positive regulation of B cell differentiation ; phospholipid transport ; ion transmembrane transport ; phospholipid translocation ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	286410
	320940
	ENSG00000101974
	ENSMUSG00000062949
	Q8NB49
	Q9QZW0
	NM_001010986 ; NM_173694 ; NM_001353810 ; NM_001353811 ; NM_001353812
	NM_001001798 ; NM_001037863 ; NM_001359002
	NP_001010986 ; NP_775965 ; NP_001340739 ; NP_001340740 ; NP_001340741
	NP_001001798 ; NP_001032952 ; NP_001345931
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated July 30, 2023

ATP11C is an enzyme that in humans is encoded by the ATP11C gene.

Function

ATP11C encodes a member of the Type IV P-type ATPase family that is thought to transport or 'flip' aminophospholipids. The corresponding protein in mice is essential for the development of B cells and red blood cells,^[5]^[6] and for the prevention of intrahepatic cholestasis.^[7]

Related Research Articles

Probable phospholipid-transporting ATPase IC is an enzyme that in humans is encoded by the ATP8B1 gene. This protein is associated with progressive familial intrahepatic cholestasis type 1 as well as benign recurrent intrahepatic cholestasis.

V-type proton ATPase subunit B, brain isoform is an enzyme that in humans is encoded by the ATP6V1B2 gene.

V-type proton ATPase subunit C 1 is an enzyme that in humans is encoded by the ATP6V1C1 gene.

Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.

V-type proton ATPase catalytic subunit A is an enzyme that in humans is encoded by the ATP6V1A gene.

V-type proton ATPase subunit G 1 is an enzyme that in humans is encoded by the ATP6V1G1 gene.

V-type proton ATPase subunit D is an enzyme that in humans is encoded by the ATP6V1D gene.

V-type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0B gene.

V-type proton ATPase 116 kDa subunit a isoform 2 also known as V-ATPase 116 kDa isoform a2 is an enzyme that in humans is encoded by the ATP6V0A2 gene.

Plasma membrane calcium-transporting ATPase 3 is an enzyme that in humans is encoded by the ATP2B3 gene.

ATP synthase subunit s, mitochondrial is an enzyme that in humans is encoded by the ATP5S gene.

Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene. ATP1B3 has also been designated as CD298.

The human gene ATP5PD encodes subunit d of the peripheral stalk part of the enzyme mitochondrial ATP synthase.

Probable cation-transporting ATPase 13A3 is an enzyme that in humans is encoded by the ATP13A3 gene.

ATP synthase subunit O, mitochondrial is an enzyme that in humans is encoded by the ATP5PO gene.

V-type proton ATPase subunit E 2 is an enzyme that in humans is encoded by the ATP6V1E2 gene.

Probable phospholipid-transporting ATPase IF is an enzyme that in humans is encoded by the ATP11B gene.

Phospholipid-transporting ATPase VA also known as ATPase class V type 10A or aminophospholipid translocase VA is an enzyme that in humans is encoded by the ATP10A gene.

The human gene ATP8B3 encodes the protein ATPase, aminophospholipid transporter, class I, type 8B, member 3.

Zinc finger and BTB domain containing 1 is a protein in humans that is encoded by the ZBTB1 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000101974 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062949 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B (May 2011). "The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow". Nature Immunology. 12 (5): 434–40. doi:10.1038/ni.2012. PMC 3079768 . PMID 21423172.
↑ Yabas M, Teh CE, Frankenreiter S, Lal D, Roots CM, Whittle B, Andrews DT, Zhang Y, Teoh NC, Sprent J, Tze LE, Kucharska EM, Kofler J, Farell GC, Bröer S, Goodnow CC, Enders A (May 2011). "ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes". Nature Immunology. 12 (5): 441–9. doi:10.1038/ni.2011. PMC 3272780 . PMID 21423173.
↑ Siggs OM, Schnabl B, Webb B, Beutler B (May 2011). "X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C". Proceedings of the National Academy of Sciences of the United States of America. 108 (19): 7890–5. Bibcode:2011PNAS..108.7890S. doi: 10.1073/pnas.1104631108 . PMC 3093471 . PMID 21518881.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000101974 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062949 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid21423172-5] Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B (May 2011). "The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow". Nature Immunology. 12 (5): 434–40. doi:10.1038/ni.2012. PMC 3079768 . PMID 21423172.

[pmid21423173-6] Yabas M, Teh CE, Frankenreiter S, Lal D, Roots CM, Whittle B, Andrews DT, Zhang Y, Teoh NC, Sprent J, Tze LE, Kucharska EM, Kofler J, Farell GC, Bröer S, Goodnow CC, Enders A (May 2011). "ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes". Nature Immunology. 12 (5): 441–9. doi:10.1038/ni.2011. PMC 3272780 . PMID 21423173.

[pmid21518881-7] Siggs OM, Schnabl B, Webb B, Beutler B (May 2011). "X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C". Proceedings of the National Academy of Sciences of the United States of America. 108 (19): 7890–5. Bibcode:2011PNAS..108.7890S. doi: 10.1073/pnas.1104631108 . PMC 3093471 . PMID 21518881.

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