ATP11C

Last updated
ATP11C
Identifiers
Aliases ATP11C , ATPIG, ATPIQ, ATPase phospholipid transporting 11C, HACXL
External IDs OMIM: 300516 MGI: 1859661 HomoloGene: 27862 GeneCards: ATP11C
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001010986
NM_173694
NM_001353810
NM_001353811
NM_001353812

NM_001001798
NM_001037863
NM_001359002

RefSeq (protein)

NP_001010986
NP_775965
NP_001340739
NP_001340740
NP_001340741

NP_001001798
NP_001032952
NP_001345931

Location (UCSC) Chr X: 139.73 – 139.95 Mb Chr X: 59.27 – 59.64 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ATP11C is an enzyme that in humans is encoded by the ATP11C gene.

Function

ATP11C encodes a member of the Type IV P-type ATPase family that is thought to transport or 'flip' aminophospholipids. The corresponding protein in mice is essential for the development of B cells and red blood cells, [5] [6] and for the prevention of intrahepatic cholestasis. [7]

Related Research Articles

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Probable phospholipid-transporting ATPase IC is an enzyme that in humans is encoded by the ATP8B1 gene. This protein is associated with progressive familial intrahepatic cholestasis type 1 as well as benign recurrent intrahepatic cholestasis.

<span class="mw-page-title-main">ATP6V1B2</span> Protein-coding gene in the species Homo sapiens

V-type proton ATPase subunit B, brain isoform is an enzyme that in humans is encoded by the ATP6V1B2 gene.

<span class="mw-page-title-main">ATP6V1C1</span> Protein-coding gene in the species Homo sapiens

V-type proton ATPase subunit C 1 is an enzyme that in humans is encoded by the ATP6V1C1 gene.

<span class="mw-page-title-main">ATP1A4</span> Protein-coding gene in the species Homo sapiens

Sodium/potassium-transporting ATPase subunit alpha-4 is an enzyme that in humans is encoded by the ATP1A4 gene.

<span class="mw-page-title-main">ATP6V1A</span> Protein-coding gene in the species Homo sapiens

V-type proton ATPase catalytic subunit A is an enzyme that in humans is encoded by the ATP6V1A gene.

<span class="mw-page-title-main">ATP6V1G1</span> Protein-coding gene in the species Homo sapiens

V-type proton ATPase subunit G 1 is an enzyme that in humans is encoded by the ATP6V1G1 gene.

<span class="mw-page-title-main">ATP6V1D</span> Protein-coding gene in the species Homo sapiens

V-type proton ATPase subunit D is an enzyme that in humans is encoded by the ATP6V1D gene.

<span class="mw-page-title-main">ATP6V0B</span> Protein-coding gene in Homo sapiens

V-type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0B gene.

<span class="mw-page-title-main">ATP6V0A2</span> Protein-coding gene in the species Homo sapiens

V-type proton ATPase 116 kDa subunit a isoform 2 also known as V-ATPase 116 kDa isoform a2 is an enzyme that in humans is encoded by the ATP6V0A2 gene.

<span class="mw-page-title-main">ATP2B3</span> Protein-coding gene in humans

Plasma membrane calcium-transporting ATPase 3 is an enzyme that in humans is encoded by the ATP2B3 gene.

<span class="mw-page-title-main">ATP5S</span> Protein-coding gene in the species Homo sapiens

ATP synthase subunit s, mitochondrial is an enzyme that in humans is encoded by the ATP5S gene.

<span class="mw-page-title-main">ATP1B3</span> Protein-coding gene in the species Homo sapiens

Sodium/potassium-transporting ATPase subunit beta-3 is an enzyme that in humans is encoded by the ATP1B3 gene. ATP1B3 has also been designated as CD298.

<span class="mw-page-title-main">ATP5H</span> Protein-coding gene in the species Homo sapiens

The human gene ATP5PD encodes subunit d of the peripheral stalk part of the enzyme mitochondrial ATP synthase.

<span class="mw-page-title-main">ATP13A3</span> Protein-coding gene in the species Homo sapiens

Probable cation-transporting ATPase 13A3 is an enzyme that in humans is encoded by the ATP13A3 gene.

<span class="mw-page-title-main">ATP5PO</span> Protein-coding gene in the species Homo sapiens

ATP synthase subunit O, mitochondrial is an enzyme that in humans is encoded by the ATP5PO gene.

<span class="mw-page-title-main">ATP6V1E2</span> Protein-coding gene in the species Homo sapiens

V-type proton ATPase subunit E 2 is an enzyme that in humans is encoded by the ATP6V1E2 gene.

<span class="mw-page-title-main">ATP11B</span> Protein-coding gene in the species Homo sapiens

Probable phospholipid-transporting ATPase IF is an enzyme that in humans is encoded by the ATP11B gene.

<span class="mw-page-title-main">Phospholipid-transporting ATPase VA</span> Protein-coding gene in the species Homo sapiens

Phospholipid-transporting ATPase VA also known as ATPase class V type 10A or aminophospholipid translocase VA is an enzyme that in humans is encoded by the ATP10A gene.

<span class="mw-page-title-main">ATP8B3</span> Protein-coding gene in the species Homo sapiens

The human gene ATP8B3 encodes the protein ATPase, aminophospholipid transporter, class I, type 8B, member 3.

<span class="mw-page-title-main">ZBTB1</span> Protein-coding gene in the species Homo sapiens

Zinc finger and BTB domain containing 1 is a protein in humans that is encoded by the ZBTB1 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000101974 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000062949 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Siggs OM, Arnold CN, Huber C, Pirie E, Xia Y, Lin P, Nemazee D, Beutler B (May 2011). "The P4-type ATPase ATP11C is essential for B lymphopoiesis in adult bone marrow". Nature Immunology. 12 (5): 434–40. doi:10.1038/ni.2012. PMC   3079768 . PMID   21423172.
  6. Yabas M, Teh CE, Frankenreiter S, Lal D, Roots CM, Whittle B, Andrews DT, Zhang Y, Teoh NC, Sprent J, Tze LE, Kucharska EM, Kofler J, Farell GC, Bröer S, Goodnow CC, Enders A (May 2011). "ATP11C is critical for the internalization of phosphatidylserine and differentiation of B lymphocytes". Nature Immunology. 12 (5): 441–9. doi:10.1038/ni.2011. PMC   3272780 . PMID   21423173.
  7. Siggs OM, Schnabl B, Webb B, Beutler B (May 2011). "X-linked cholestasis in mouse due to mutations of the P4-ATPase ATP11C". Proceedings of the National Academy of Sciences of the United States of America. 108 (19): 7890–5. Bibcode:2011PNAS..108.7890S. doi: 10.1073/pnas.1104631108 . PMC   3093471 . PMID   21518881.