ATP6V1A

Last updated
ATP6V1A
Identifiers
Aliases ATP6V1A , ATP6A1, ATP6V1A1, HO68, VA68, VPP2, Vma1, ATPase H+ transporting V1 subunit A, ARCL2D, IECEE3, DEE93
External IDs OMIM: 607027 MGI: 1201780 HomoloGene: 123934 GeneCards: ATP6V1A
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001690

NM_007508
NM_001358203
NM_001358204

RefSeq (protein)

NP_001681

NP_031534
NP_001345132
NP_001345133

Location (UCSC) Chr 3: 113.75 – 113.81 Mb Chr 16: 44.09 – 44.14 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

V-type proton ATPase catalytic subunit A is an enzyme that in humans is encoded by the ATP6V1A gene. [5] [6]

Contents

This gene encodes a component of vacuolar ATPase (V-ATPase), a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c', c", and d. Additional isoforms of many of the V1 and V0 subunit proteins are encoded by multiple genes or alternatively spliced transcript variants. This encoded protein is one of two V1 domain A subunit isoforms and is found in all tissues. Transcript variants derived from alternative polyadenylation exist. [6]

Related Research Articles

ATP6V1B1

V-type proton ATPase subunit B, kidney isoform is an enzyme that in humans is encoded by the ATP6V1B1 gene.

ATP6V1E1

V-type proton ATPase subunit E 1 is an enzyme that in humans is encoded by the ATP6V1E1 gene.

TCIRG1 Mammalian gene encoding V-ATPase enzyme

The TCIRG1 gene encodes for the V-type proton ATPase (V-ATPase) 116 kDa subunit a isoform 3 enzyme.

ATP6V0C

V-type proton ATPase 16 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0C gene.

ATP6V1B2

V-type proton ATPase subunit B, brain isoform is an enzyme that in humans is encoded by the ATP6V1B2 gene.

ATP6AP1

The human gene ATP6AP1 encodes the S1 subunit of the enzyme V-type proton ATPase.

ATP6V0A4

V-type proton ATPase 116 kDa subunit a isoform 4 is an enzyme that in humans is encoded by the ATP6V0A4 gene.

ATP6V1C1

V-type proton ATPase subunit C 1 is an enzyme that in humans is encoded by the ATP6V1C1 gene.

ATPase, H+ transporting, lysosomal V0 subunit a1

V-type proton ATPase 116 kDa subunit a isoform 1 is an enzyme that in humans is encoded by the ATP6V0A1 gene.

ATP6V0D1

V-type proton ATPase subunit d 1 is an enzyme that in humans is encoded by the ATP6V0D1 gene.

ATP6V1G2 Protein-coding gene in Homo sapiens

V-type proton ATPase subunit G 2 is an enzyme that in humans is encoded by the ATP6V1G2 gene.

ATP6V1H

V-type proton ATPase subunit H is an enzyme that in humans is encoded by the ATP6V1H gene.

ATP6V1G1

V-type proton ATPase subunit G 1 is an enzyme that in humans is encoded by the ATP6V1G1 gene.

ATP6V1D

V-type proton ATPase subunit D is an enzyme that in humans is encoded by the ATP6V1D gene.

ATP6V1F

V-type proton ATPase subunit F is an enzyme that in humans is encoded by the ATP6V1F gene.

ATP6V1G3

V-type proton ATPase subunit G 3 is an enzyme that in humans is encoded by the ATP6V1G3 gene.

ATP6V0B Protein-coding gene in Homo sapiens

V-type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0B gene.

ATP6V0E1

V-type proton ATPase subunit e 1 is an enzyme that in humans is encoded by the ATP6V0E1 gene.

ATP6V0A2

V-type proton ATPase 116 kDa subunit a isoform 2 also known as V-ATPase 116 kDa isoform a2 is an enzyme that in humans is encoded by the ATP6V0A2 gene.

ATP6V1E2

V-type proton ATPase subunit E 2 is an enzyme that in humans is encoded by the ATP6V1E2 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000114573 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000052459 - Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. van Hille B, Richener H, Evans DB, Green JR, Bilbe G (May 1993). "Identification of two subunit A isoforms of the vacuolar H(+)-ATPase in human osteoclastoma". J Biol Chem. 268 (10): 7075–80. doi:10.1016/S0021-9258(18)53147-1. PMID   8463241.
  6. 1 2 "Entrez Gene: ATP6V1A ATPase, H+ transporting, lysosomal 70kDa, V1 subunit A".

Further reading