ATP6V0D2

ATP6V0D2
Identifiers
Aliases	ATP6V0D2 , ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2, ATP6D2, VMA6, ATPase H+ transporting V0 subunit d2
External IDs	OMIM: 618072 MGI: 1924415 HomoloGene: 72090 GeneCards: ATP6V0D2
Gene location (Human)
Chr.	Chromosome 8 (human)
End	86,154,225 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	19,922,605 bp
RNA expression pattern
	Top expressed in
	kidney; ; amniotic fluid; ; renal medulla; ; rectum; ; tibia; ; lower lobe of lung; ; lymph node; ; appendix; ; islet of Langerhans; ; minor salivary gland;
	Top expressed in
	submandibular gland; ; body of femur; ; parotid gland; ; calvaria; ; kidney; ; right lung; ; right lung lobe; ; Epithelium of stomach; ; superior cervical ganglion; ; cochlea;
	More reference expression data
	n/a
Gene ontology
Molecular function	protein binding ; proton transmembrane transporter activity ; P-type proton-exporting transporter activity ; proton-transporting ATPase activity, rotational mechanism ;
Cellular component	proton-transporting V-type ATPase, V0 domain ; endosome ; phagocytic vesicle membrane ; membrane ; apical plasma membrane ; vacuolar proton-transporting V-type ATPase complex ; endosome membrane ; extracellular exosome ; lysosomal membrane ; early endosome ; plasma membrane proton-transporting V-type ATPase complex ;
Biological process	insulin receptor signaling pathway ; transferrin transport ; ion transport ; ion transmembrane transport ; regulation of macroautophagy ; phagosome acidification ; vacuolar transport ; vacuolar acidification ; transport ;
	Sources:Amigo / QuickGO
Orthologs
	245972
	242341
	ENSG00000147614
	ENSMUSG00000028238
	Q8N8Y2
	Q80SY3
	NM_152565
	NM_175406
	NP_689778
	NP_780615
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 04, 2023

ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2 is a protein in humans that is encoded by the ATP6V0D2 gene. ^[5] It is part of proton pumps in the plasma membranes of osteoclasts and aids with extracellular acidification in bone resorption. ^[6]

Related Research Articles

V-type proton ATPase subunit B, kidney isoform is an enzyme that in humans is encoded by the ATP6V1B1 gene.

V-type proton ATPase subunit E 1 is an enzyme that in humans is encoded by the ATP6V1E1 gene.

V-type proton ATPase 16 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0C gene.

V-type proton ATPase subunit B, brain isoform is an enzyme that in humans is encoded by the ATP6V1B2 gene.

The human gene ATP6AP1 encodes the S1 subunit of the enzyme V-type proton ATPase.

V-type proton ATPase 116 kDa subunit a isoform 4 is an enzyme that in humans is encoded by the ATP6V0A4 gene.

V-type proton ATPase subunit C 1 is an enzyme that in humans is encoded by the ATP6V1C1 gene.

V-type proton ATPase 116 kDa subunit a isoform 1 is an enzyme that in humans is encoded by the ATP6V0A1 gene.

V-type proton ATPase catalytic subunit A is an enzyme that in humans is encoded by the ATP6V1A gene.

V-type proton ATPase subunit d 1 is an enzyme that in humans is encoded by the ATP6V0D1 gene.

V-type proton ATPase subunit G 2 is an enzyme that in humans is encoded by the ATP6V1G2 gene.

V-type proton ATPase subunit H is an enzyme that in humans is encoded by the ATP6V1H gene.

V-type proton ATPase subunit G 1 is an enzyme that in humans is encoded by the ATP6V1G1 gene.

V-type proton ATPase subunit D is an enzyme that in humans is encoded by the ATP6V1D gene.

V-type proton ATPase subunit F is an enzyme that in humans is encoded by the ATP6V1F gene.

V-type proton ATPase subunit G 3 is an enzyme that in humans is encoded by the ATP6V1G3 gene.

V-type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP6V0B gene.

V-type proton ATPase subunit e 1 is an enzyme that in humans is encoded by the ATP6V0E1 gene.

V-type proton ATPase 116 kDa subunit a isoform 2 also known as V-ATPase 116 kDa isoform a2 is an enzyme that in humans is encoded by the ATP6V0A2 gene.

V-type proton ATPase subunit C 2 is an enzyme that in humans is encoded by the ATP6V1C2 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000147614 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028238 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: ATPase, H+ transporting, lysosomal 38kDa, V0 subunit d2" . Retrieved 2012-11-12.
↑ Wu H, Xu G, Li YP (May 2009). "Atp6v0d2 is an essential component of the osteoclast-specific proton pump that mediates extracellular acidification in bone resorption". Journal of Bone and Mineral Research. 24 (5): 871–85. doi:10.1359/jbmr.081239. PMC 2672205 . PMID 19113919.

External links

Human ATP6V0D2 genome location and ATP6V0D2 gene details page in the UCSC Genome Browser .

ATP6V0D2

Contents

Related Research Articles

References

External links

Further reading