ATP6AP1

ATP6AP1
Identifiers
Aliases	ATP6AP1 , 16A, ATP6IP1, ATP6S1, Ac45, CF2, VATPS1, XAP-3, XAP3, ATPase H+ transporting accessory protein 1
External IDs	OMIM: 300197 MGI: 109629 HomoloGene: 914 GeneCards: ATP6AP1
Gene location (Human) Chr. X chromosome (human) [1] Band Xq28 Start 154,428,633 bp [1] End 154,436,516 bp [1]
Gene location (Mouse) Chr. X chromosome (mouse) [2] Band X A7.3|X 37.96 cM Start 73,340,703 bp [2] End 73,348,327 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in Brodmann area 10 islet of Langerhans stromal cell of endometrium anterior pituitary frontal pole middle frontal gyrus cingulate gyrus Brodmann area 9 right lung cerebellar vermis Top expressed in superior frontal gyrus calvaria epithelium of stomach cerebellar cortex anterior horn of spinal cord hippocampus proper temporal lobe body of femur amygdala cingulate gyrus More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding proton-transporting ATP synthase activity, rotational mechanism transporter activity proton-transporting ATPase activity, rotational mechanism ATP binding Cellular component integral component of membrane proton-transporting V-type ATPase, V1 domain membrane proton-transporting two-sector ATPase complex endosome membrane extracellular exosome endoplasmic reticulum endoplasmic reticulum membrane endoplasmic reticulum-Golgi intermediate compartment membrane plasma membrane proton-transporting V-type ATPase complex Biological process insulin receptor signaling pathway transferrin transport pH reduction ion transport positive regulation of bone resorption positive regulation of osteoclast development establishment of organelle localization ion transmembrane transport positive regulation of osteoblast differentiation positive regulation of ERK1 and ERK2 cascade positive regulation of exocytosis cellular iron ion homeostasis cellular response to increased oxygen levels transport regulation of cellular pH proton transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 537 54411 Ensembl ENSG00000071553 ENSMUSG00000019087 UniProt Q15904 Q9R1Q9 RefSeq (mRNA) NM_001183 NM_018794 NM_001358375 NM_001358380 RefSeq (protein) NP_001174 NP_061264 NP_001345304 NP_001345309 Location (UCSC) Chr X: 154.43 – 154.44 Mb Chr X: 73.34 – 73.35 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

The human gene ATP6AP1 encodes the S1 subunit of the enzyme V-type proton ATPase. ^{[5] [6] [7]}

This gene encodes a component of a multisubunit enzyme (1 mDa MW) that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is composed of a cytosolic, V₁, (site of the ATP catalytic site) and a transmembrane, V₀, domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene is approximately 45 kD and may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000071553 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000019087 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Chen EY, Zollo M, Mazzarella R, Ciccodicola A, Chen CN, Zuo L, Heiner C, Burough F, Repetto M, Schlessinger D, D'Urso M (Jun 1997). "Long-range sequence analysis in Xq28: thirteen known and six candidate genes in 219.4 kb of high GC DNA between the RCP/GCP and G6PD loci". Hum Mol Genet. 5 (5): 659–68. doi: 10.1093/hmg/5.5.659 . PMID   8733135.
6. Sedlacek Z, Korn B, Konecki DS, Siebenhaar R, Coy JF, Kioschis P, Poustka A (Feb 1994). "Construction of a transcription map of a 300 kb region around the human G6PD locus by direct cDNA selection". Hum Mol Genet. 2 (11): 1865–9. doi:10.1093/hmg/2.11.1865. PMID   8281148.
7. "Entrez Gene: ATP6AP1 ATPase, H+ transporting, lysosomal accessory protein 1".

External links

• Human ATP6AP1 genome location and ATP6AP1 gene details page in the UCSC Genome Browser .

Further reading

• Finbow ME, Harrison MA (1997). "The vacuolar H+-ATPase: a universal proton pump of eukaryotes". Biochem. J. 324 (3): 697–712. doi:10.1042/bj3240697. PMC   1218484 . PMID   9210392.
• Stevens TH, Forgac M (1998). "Structure, function and regulation of the vacuolar (H+)-ATPase". Annu. Rev. Cell Dev. Biol. 13: 779–808. doi:10.1146/annurev.cellbio.13.1.779. PMID   9442887.
• Nelson N, Harvey WR (1999). "Vacuolar and plasma membrane proton-adenosinetriphosphatases". Physiol. Rev. 79 (2): 361–85. doi:10.1152/physrev.1999.79.2.361. PMID   10221984. S2CID   1477911.
• Forgac M (1999). "Structure and properties of the vacuolar (H+)-ATPases". J. Biol. Chem. 274 (19): 12951–4. doi: 10.1074/jbc.274.19.12951 . PMID   10224039.
• Kane PM (1999). "Introduction: V-ATPases 1992-1998". J. Bioenerg. Biomembr. 31 (1): 3–5. doi:10.1023/A:1001884227654. PMID   10340843.
• Wieczorek H, Brown D, Grinstein S, et al. (1999). "Animal plasma membrane energization by proton-motive V-ATPases". BioEssays. 21 (8): 637–48. doi:10.1002/(SICI)1521-1878(199908)21:8<637::AID-BIES3>3.0.CO;2-W. PMID   10440860. S2CID   23505139.
• Yokoi H, Hadano S, Kogi M, et al. (1994). "Isolation of expressed sequences encoded by the human Xq terminal portion using microclone probes generated by laser microdissection". Genomics. 20 (3): 404–11. doi:10.1006/geno.1994.1194. PMID   8034313.
• Holthuis JC, Jansen EJ, Schoonderwoert VT, et al. (1999). "Biosynthesis of the vacuolar H+-ATPase accessory subunit Ac45 in Xenopus pituitary". Eur. J. Biochem. 262 (2): 484–91. doi:10.1046/j.1432-1327.1999.00396.x. PMID   10336633.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Bagai S, Rubio E, Cheng JF, et al. (2002). "Fibroblast growth factor-10 is a mitogen for urothelial cells". J. Biol. Chem. 277 (26): 23828–37. doi: 10.1074/jbc.M201658200 . PMID   11923311.
• Hodi FS, Schmollinger JC, Soiffer RJ, et al. (2002). "ATP6S1 elicits potent humoral responses associated with immune-mediated tumor destruction". Proc. Natl. Acad. Sci. U.S.A. 99 (10): 6919–24. Bibcode:2002PNAS...99.6919H. doi: 10.1073/pnas.102025999 . PMC   124504 . PMID   11983866.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.