ATP5L

ATP5MG
Identifiers
Aliases	ATP5MG , ATP5JG, ATP synthase, H+ transporting, mitochondrial Fo complex subunit G, ATP synthase membrane subunit g, ATP5L
External IDs	OMIM: 617473; MGI: 1351597; HomoloGene: 86074; GeneCards: ATP5MG; OMA:ATP5MG - orthologs
Gene location (Human) Chr. Chromosome 11 (human) [1] Band 11q23.3 Start 118,401,346 bp [1] End 118,433,278 bp [1]
Gene location (Mouse) Chr. Chromosome 9 (mouse) [2] Band 9|9 A5.2 Start 44,823,855 bp [2] End 44,832,040 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in ganglionic eminence left ventricle mucosa of transverse colon bone marrow cells right auricle of heart renal medulla apex of heart right ventricle myocardium of left ventricle left adrenal gland Top expressed in quadriceps femoris muscle skeletal muscle tissue right kidney heart muscle of thigh yolk sac stomach proximal tubule dentate gyrus of hippocampal formation granule cell neural tube More reference expression data BioGPS More reference expression data
Gene ontology Molecular function ATPase activity transmembrane transporter activity proton transmembrane transporter activity proton-transporting ATP synthase activity, rotational mechanism Cellular component mitochondrial inner membrane mitochondrial proton-transporting ATP synthase complex mitochondrion membrane proton-transporting ATP synthase complex, coupling factor F(o) mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) Biological process mitochondrial ATP synthesis coupled proton transport ion transport ATP biosynthetic process ATP synthesis coupled proton transport cristae formation Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10632 27425 Ensembl ENSG00000167283 ENSMUSG00000038717 UniProt O75964 Q9CPQ8 RefSeq (mRNA) NM_006476 NM_013795 RefSeq (protein) NP_006467 NP_038823 Location (UCSC) Chr 11: 118.4 – 118.43 Mb Chr 9: 44.82 – 44.83 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

ATP-synt_G
Identifiers
Symbol	ATP-synt_G
Pfam	PF04718
InterPro	IPR006808
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

ATP synthase subunit g, mitochondrial is an enzyme that in humans is encoded by the ATP5MG gene. ^{[5] [6] [7]}

Mitochondrial ATP synthase catalyzes ATP synthesis, utilizing an electrochemical gradient of protons across the inner membrane during oxidative phosphorylation. It is composed of two linked multi-subunit complexes: the soluble catalytic core, F1, and the membrane-spanning component, Fo, which comprises the proton channel. The F1 complex consists of 5 different subunits (alpha, beta, gamma, delta, and epsilon) assembled in a ratio of 3 alpha, 3 beta, and a single representative of the other 3. The Fo seems to have nine subunits (a, b, c, d, e, f, g, F6 and 8). This gene encodes the g subunit of the F0 complex. ^[7]

The function of subunit G is currently unknown. There is no counterpart in chloroplast or bacterial F-ATPases identified so far. ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000167283 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000038717 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Bocher M, Blocker H, Bauersachs S, Blum H, Lauber J, Dusterhoft A, Beyer A, Kohrer K, Strack N, Mewes HW, Ottenwalder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A (Mar 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome Res. 11 (3): 422–35. doi:10.1101/gr.GR1547R. PMC   311072 . PMID   11230166.
6. Zhang QH, Ye M, Wu XY, Ren SX, Zhao M, Zhao CJ, Fu G, Shen Y, Fan HY, Lu G, Zhong M, Xu XR, Han ZG, Zhang JW, Tao J, Huang QH, Zhou J, Hu GX, Gu J, Chen SJ, Chen Z (Nov 2000). "Cloning and functional analysis of cDNAs with open reading frames for 300 previously undefined genes expressed in CD34+ hematopoietic stem/progenitor cells". Genome Res. 10 (10): 1546–60. doi:10.1101/gr.140200. PMC   310934 . PMID   11042152.
7. "Entrez Gene: ATP5MG ATP synthase membrane subunit g".
8. Collinson IR, Runswick MJ, Buchanan SK, Fearnley IM, Skehel JM, van Raaij MJ, Griffiths DE, Walker JE (June 1994). "Fo membrane domain of ATP synthase from bovine heart mitochondria: purification, subunit composition, and reconstitution with F1-ATPase". Biochemistry. 33 (25): 7971–8. doi:10.1021/bi00191a026. PMID   8011660.

External links

• Human ATP5MG genome location and ATP5MG gene details page in the UCSC Genome Browser .

Further reading

• Kinosita K, Yasuda R, Noji H (2003). "F1-ATPase: a highly efficient rotary ATP machine". Essays Biochem. 35: 3–18. doi:10.1042/bse0350003. PMID   12471886.
• Oster G, Wang H (2003). "Rotary protein motors". Trends Cell Biol. 13 (3): 114–21. doi:10.1016/S0962-8924(03)00004-7. PMID   12628343.
• Leyva JA, Bianchet MA, Amzel LM (2003). "Understanding ATP synthesis: structure and mechanism of the F1-ATPase (Review)". Mol. Membr. Biol. 20 (1): 27–33. doi: 10.1080/0968768031000066532 . PMID   12745923. S2CID   218895820.
• Elston T, Wang H, Oster G (1998). "Energy transduction in ATP synthase". Nature. 391 (6666): 510–3. Bibcode:1998Natur.391..510E. doi:10.1038/35185. PMID   9461222. S2CID   4406161.
• Wang H, Oster G (1998). "Energy transduction in the F1 motor of ATP synthase". Nature. 396 (6708): 279–82. Bibcode:1998Natur.396..279W. doi:10.1038/24409. PMID   9834036. S2CID   4424498.
• Hartley JL, Temple GF, Brasch MA (2001). "DNA cloning using in vitro site-specific recombination". Genome Res. 10 (11): 1788–95. doi:10.1101/gr.143000. PMC   310948 . PMID   11076863.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Cross RL (2004). "Molecular motors: turning the ATP motor". Nature. 427 (6973): 407–8. Bibcode:2004Natur.427..407C. doi: 10.1038/427407b . PMID   14749816. S2CID   52819856.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Wiemann S, Arlt D, Huber W, et al. (2004). "From ORFeome to biology: a functional genomics pipeline". Genome Res. 14 (10B): 2136–44. doi:10.1101/gr.2576704. PMC   528930 . PMID   15489336.
• Mehrle A, Rosenfelder H, Schupp I, et al. (2006). "The LIFEdb database in 2006". Nucleic Acids Res. 34 (Database issue): D415–8. doi:10.1093/nar/gkj139. PMC   1347501 . PMID   16381901.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.

This article incorporates text from the public domain Pfam and InterPro: IPR006808