C-type lectin

Last updated
Lectin C-type domain
PDB 1jzn EBI.jpg
Pentameric structure of rattlesnake venom lectin which is a galactose binding lectin. [1] [2]
Identifiers
SymbolLectin_C
Pfam PF00059
InterPro IPR001304
SMART CLECT
PROSITE PS50041
SCOP2 2msb / SCOPe / SUPFAM
CDD cd00037
Available protein structures:
Pfam   structures / ECOD  
PDB RCSB PDB; PDBe; PDBj
PDBsum structure summary

A C-type lectin (CLEC) is a type of carbohydrate-binding protein known as a lectin. [3] The C-type designation is from their requirement for calcium for binding. [4] Proteins that contain C-type lectin domains have a diverse range of functions including cell-cell adhesion, immune response to pathogens and apoptosis. [5] [6]

Contents

Classification

Drickamer et al. classified C-type lectins into seven subgroups (I to VII) based on the order of the various protein domains in each protein. [7] This classification was subsequently updated in 2002, leading to seven additional groups (VIII to XIV). [8] Most recently, three further subgroups were added (XV to XVII). [3]

GroupNameAssociated domains
I Lecticans EGF, Sushi, Ig and Link domains
II Asialoglycoprotein and DC receptorsNone
III Collectins None
IV Selectins Sushi and EGF domains
V NK - cell receptorsNone
VIMulti-CTLD endocytic receptorsFnII and Ricin domains
VIIReg groupNone
VIII Chondrolectin, Layilin None
IX Tetranectin None
X Polycystin WSC, REJ, PKD domains
XIAttractin (ATRN)PSI, EGF and CUB domains
XII Eosinophil major basic protein (EMBP)None
XIII DGCR2 None
XIV Thrombomodulin, CD93, CD248, CLEC14A EGF domains [9]
XV Bimlec None
XVISEEC SCP and EGF domains
XVIICBCP/Frem1/QBRICKCSPG repeats and CalX-beta domains

CLECs include:

The "NK Cell lectin-like receptors" are a very closely related group: [10]

Additional proteins containing this domain include:

References

  1. ↑ Walker JR, Nagar B, Young NM, Hirama T, Rini JM (April 2004). "X-ray crystal structure of a galactose-specific C-type lectin possessing a novel decameric quaternary structure". Biochemistry. 43 (13): 3783–92. doi:10.1021/bi035871a. PMID   15049685.
  2. ↑ Mahla RS, Reddy MC, Prasad DV, Kumar H (September 2013). "Sweeten PAMPs: Role of Sugar Complexed PAMPs in Innate Immunity and Vaccine Biology". Frontiers in Immunology. 4: 248. doi: 10.3389/fimmu.2013.00248 . PMC   3759294 . PMID   24032031.
  3. 1 2 Zelensky AN, Gready JE (December 2005). "The C-type lectin-like domain superfamily". FEBS J. 272 (24): 6179–217. doi:10.1111/j.1742-4658.2005.05031.x. PMID   16336259. S2CID   7084402.
  4. ↑ C-Type+Lectin at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
  5. ↑ Drickamer K (October 1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID   10508765.
  6. ↑ Cambi A, Figdor C (May 2009). "Necrosis: C-type lectins sense cell death". Curr. Biol. 19 (9): R375–8. Bibcode:2009CBio...19.R375C. doi: 10.1016/j.cub.2009.03.032 . PMID   19439262. S2CID   17409821.
  7. ↑ Drickamer K (1993). "Evolution of Ca(2+)-dependent animal lectins". Prog. Nucleic Acid Res. Mol. Biol. Progress in Nucleic Acid Research and Molecular Biology. 45: 207–32. doi: 10.1016/S0079-6603(08)60870-3 . ISBN   978-0-12-540045-9. PMID   8341801.
  8. ↑ Drickamer K, Fadden AJ (2002). "Genomic analysis of C-type lectins". Biochem. Soc. Symp. 69 (69): 59–72. doi:10.1042/bss0690059. PMID   12655774.
  9. ↑ Khan, K. A.; McMurray, J. L.; Mohammed, F.; Bicknell, R. (2019). "C-type lectin domain group 14 proteins in vascular biology, cancer and inflammation". FEBS Journal. 286 (17): 3299–3332. doi:10.1111/febs.14985. PMC   6852297 . PMID   31287944.
  10. ↑ NK+Cell+Lectin-Like+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
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