CLEC11A

CLEC11A
Identifiers
Aliases	CLEC11A , CLECSF3, LSLCL, P47, SCGF, C-type lectin domain family 11 member A, C-type lectin domain containing 11A
External IDs	OMIM: 604713; MGI: 1298219; HomoloGene: 2236; GeneCards: CLEC11A; OMA:CLEC11A - orthologs
Gene location (Human) Chr. Chromosome 19 (human) [1] Band 19q13.33 Start 50,723,364 bp [1] End 50,725,708 bp [1]
Gene location (Mouse) Chr. Chromosome 7 (mouse) [2] Band 7|7 B3 Start 43,952,111 bp [2] End 43,956,326 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in stromal cell of endometrium tibia periodontal fiber trabecular bone canal of the cervix bone marrow right ovary left uterine tube left ovary right uterine tube Top expressed in calvaria body of femur fossa condyle umbilical cord molar ankle vestibular sensory epithelium ascending aorta carotid body More reference expression data BioGPS More reference expression data
Gene ontology Molecular function growth factor activity carbohydrate binding Cellular component cytoplasm extracellular region extracellular space Biological process positive regulation of cell population proliferation ossification regulation of signaling receptor activity signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 6320 20256 Ensembl ENSG00000105472 ENSMUSG00000004473 UniProt Q9Y240 O88200 RefSeq (mRNA) NM_002975 NM_009131 RefSeq (protein) NP_002966 NP_033157 Location (UCSC) Chr 19: 50.72 – 50.73 Mb Chr 7: 43.95 – 43.96 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

C-type lectin domain family 11 member A is a protein that in humans is encoded by the CLEC11A gene. ^{[5] [6] [7]}

Function

This gene encodes a member of the C-type lectin superfamily. The encoded protein is a secreted sulfated glycoprotein and functions as a growth factor for primitive hematopoietic progenitor cells. An alternative splice variant has been described but its biological nature has not been determined. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000105472 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000004473 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hiraoka A, Sugimura A, Seki T, Nagasawa T, Ohta N, Shimonishi M, Hagiya M, Shimizu S (July 1997). "Cloning, expression, and characterization of a cDNA encoding a novel human growth factor for primitive hematopoietic progenitor cells". Proceedings of the National Academy of Sciences of the United States of America. 94 (14): 7577–82. Bibcode:1997PNAS...94.7577H. doi: 10.1073/pnas.94.14.7577 . PMC   23864 . PMID   9207134.
6. Bannwarth S, Giordanengo V, Lesimple J, Lefebvre JC (January 1998). "Molecular cloning of a new secreted sulfated mucin-like protein with a C-type lectin domain that is expressed in lymphoblastic cells". The Journal of Biological Chemistry. 273 (4): 1911–6. doi: 10.1074/jbc.273.4.1911 . PMID   9442024.
7. "Entrez Gene: CLEC11A C-type lectin domain family 11, member A".

Further reading

• Hiraoka A, Ohkubo T, Fukuda M (October 1987). "Production of human hematopoietic survival and growth factor by a myeloid leukemia cell line (KPB-M15) and placenta as detected by a monoclonal antibody". Cancer Research. 47 (19): 5025–30. PMID   3304620.
• Mio H, Kagami N, Yokokawa S, Kawai H, Nakagawa S, Takeuchi K, Sekine S, Hiraoka A (August 1998). "Isolation and characterization of a cDNA for human mouse, and rat full-length stem cell growth factor, a new member of C-type lectin superfamily". Biochemical and Biophysical Research Communications. 249 (1): 124–30. doi:10.1006/bbrc.1998.9073. PMID   9705843.
• Bannwarth S, Giordanengo V, Grosgeorge J, Turc-Carel C, Lefebvre JC (April 1999). "Cloning, mapping, and genomic organization of the LSLCL gene, encoding a new lymphocytic secreted mucin-like protein with a C-type lectin domain: A new model of exon shuffling". Genomics. 57 (2): 316–7. doi:10.1006/geno.1999.5762. PMID   10198175.
• Gehling UM, Ergün S, Schumacher U, Wagener C, Pantel K, Otte M, Schuch G, Schafhausen P, Mende T, Kilic N, Kluge K, Schäfer B, Hossfeld DK, Fiedler W (May 2000). "In vitro differentiation of endothelial cells from AC133-positive progenitor cells". Blood. 95 (10): 3106–12. doi:10.1182/blood.V95.10.3106. PMID   10807776.
• Perrin C, Bayle J, Bannwarth S, Michiels JF, Heudier P, Lefebvre JC, Giordanengo V (December 2001). "Expression of LSLCL, a new C-type lectin, is closely restricted, in bone marrow, to immature neutrophils". Comptes Rendus de l'Académie des Sciences, Série III. 324 (12): 1125–32. doi:10.1016/s0764-4469(01)01392-0. PMID   11803813.
• Hiraoka A, Yano Ki K, Kagami N, Takeshige K, Mio H, Anazawa H, Sugimoto S (2002). "Stem cell growth factor: in situ hybridization analysis on the gene expression, molecular characterization and in vitro proliferative activity of a recombinant preparation on primitive hematopoietic progenitor cells". The Hematology Journal. 2 (5): 307–15. doi:10.1038/sj.thj.6200118. PMID   11920266.
• Ito C, Sato H, Ando K, Watanabe S, Yoshiba F, Kishi K, Furuya A, Shitara K, Sugimoto S, Kohno H, Hiraoka A, Hotta T (August 2003). "Serum stem cell growth factor for monitoring hematopoietic recovery following stem cell transplantation". Bone Marrow Transplantation. 32 (4): 391–8. doi: 10.1038/sj.bmt.1704152 . PMID   12900775.
• Lee E, Min HK, Oskeritzian CA, Kambe N, Schwartz LB, Wook Chang H (November 2003). "Recombinant human (rh) stem cell factor and rhIL-4 stimulate differentiation and proliferation of CD3+ cells from umbilical cord blood and CD3+ cells enhance FcepsilonR1 expression on fetal liver-derived mast cells in the presence of rhIL-4". Cellular Immunology. 226 (1): 30–6. doi:10.1016/j.cellimm.2003.11.001. PMID   14746805.
• Hollenbeck ST, Sakakibara K, Faries PL, Workhu B, Liu B, Kent KC (August 2004). "Stem cell factor and c-kit are expressed by and may affect vascular SMCs through an autocrine pathway". The Journal of Surgical Research. 120 (2): 288–94. doi:10.1016/j.jss.2004.01.005. PMID   15234225.

External links

• Human CLEC11A genome location and CLEC11A gene details page in the UCSC Genome Browser .