CLEC1A

CLEC1A
Identifiers
Aliases	CLEC1A , CLEC-1, CLEC1, C-type lectin domain family 1 member A
External IDs	OMIM: 606782 MGI: 2444151 HomoloGene: 9549 GeneCards: CLEC1A
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.2 Start 10,069,554 bp [1] End 10,111,627 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 F3 Start 129,401,735 bp [2] End 129,428,963 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in placenta upper lobe of left lung right lung subcutaneous adipose tissue tibial nerve canal of the cervix left uterine tube gastric mucosa smooth muscle tissue left lobe of thyroid gland Top expressed in left lung lobe right lung right lung lobe renal corpuscle carotid body sciatic nerve atrioventricular valve cumulus cell myocardium of ventricle mammary gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function transmembrane signaling receptor activity carbohydrate binding Cellular component integral component of membrane integral component of plasma membrane intracellular anatomical structure membrane Biological process cell surface receptor signaling pathway defense response Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51267 243653 Ensembl ENSG00000150048 ENSMUSG00000033082 UniProt Q8NC01 Q8BWY2 RefSeq (mRNA) NM_001297748 NM_001297749 NM_001297750 NM_001297751 NM_016511 NM_175526 NM_001347475 RefSeq (protein) NP_001284677 NP_001284678 NP_001284679 NP_001284680 NP_057595 NP_001284677.1 NP_001334404 NP_780735 Location (UCSC) Chr 12: 10.07 – 10.11 Mb Chr 6: 129.4 – 129.43 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

C-type lectin domain family 1 member A is a protein that in humans is encoded by the CLEC1A gene. ^{[5] [6] [7]}

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signalling, glycoprotein turnover, and roles in inflammation and immune response. The encoded protein may play a role in regulating dendritic cell function. Alternative splice variants have been described but their biological nature has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region. ^[7]

References

1. GRCh38: Ensembl release 89: ENSG00000150048 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000033082 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol. 30 (2): 697–704. doi: 10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M . PMID   10671229.
6. Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol. 31 (12): 3493–503. doi:10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9. PMID   11745369. S2CID   42415487.
7. "Entrez Gene: CLEC1A C-type lectin domain family 1, member A".

External links

• Human CLEC1A genome location and CLEC1A gene details page in the UCSC Genome Browser .

Further reading

• Drickamer K (1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID   10508765.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily". Proteins. 53 (1): 44–55. doi:10.1002/prot.10440. PMID   12945048. S2CID   30955198.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Otsuki T, Ota T, Nishikawa T, et al. (2007). "Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries". DNA Res. 12 (2): 117–26. doi: 10.1093/dnares/12.2.117 . PMID   16303743.