PLA2R1

Last updated
PLA2R1
Identifiers
Aliases PLA2R1 , CLEC13C, PLA2-R, PLA2G1R, PLA2IR, PLA2R, phospholipase A2 receptor 1
External IDs OMIM: 604939; MGI: 102468; HomoloGene: 32016; GeneCards: PLA2R1; OMA:PLA2R1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001007267
NM_001195641
NM_007366

NM_008867

RefSeq (protein)

NP_001007268
NP_001182570
NP_031392

NP_032893

Location (UCSC) Chr 2: 159.93 – 160.06 Mb Chr 2: 60.25 – 60.38 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Secretory phospholipase A2 receptor is a protein that in humans is encoded by the PLA2R1 gene. [5] [6] [7]

Contents

Clinical significance

M-type phospholipase A2 receptor is the major antigen in idiopathic membranous nephropathy attributed to over 70% of cases. [8]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000153246 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000054580 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ancian P, Lambeau G, Mattéi MG, Lazdunski M (Apr 1995). "The human 180-kDa receptor for secretory phospholipases A2. Molecular cloning, identification of a secreted soluble form, expression, and chromosomal localization". The Journal of Biological Chemistry. 270 (15): 8963–70. doi: 10.1074/jbc.270.15.8963 . PMID   7721806.
  6. Higashino K, Ishizaki J, Kishino J, Ohara O, Arita H (Oct 1994). "Structural comparison of phospholipase-A2-binding regions in phospholipase-A2 receptors from various mammals". European Journal of Biochemistry. 225 (1): 375–82. doi: 10.1111/j.1432-1033.1994.00375.x . PMID   7925459.
  7. "Entrez Gene: PLA2R1 phospholipase A2 receptor 1, 180kDa".
  8. Beck LH, Bonegio RG, Lambeau G, Beck DM, Powell DW, Cummins TD, Klein JB, Salant DJ (Jul 2009). "M-type phospholipase A2 receptor as target antigen in idiopathic membranous nephropathy". The New England Journal of Medicine. 361 (1): 11–21. doi:10.1056/NEJMoa0810457. PMC   2762083 . PMID   19571279.

Further reading