CLEC1B

CLEC1B
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C6U, 3WSR, 3WWK
Identifiers
Aliases	CLEC1B , 1810061I13Rik, CLEC2, CLEC2B, PRO1384, QDED721, C-type lectin domain family 1 member B
External IDs	OMIM: 606783; MGI: 1913287; HomoloGene: 49468; GeneCards: CLEC1B; OMA:CLEC1B - orthologs
Gene location (Human) Chr. Chromosome 12 (human) [1] Band 12p13.31-p13.2 Start 9,985,642 bp [1] End 10,013,424 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 F3 Start 129,374,260 bp [2] End 129,386,298 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in monocyte testicle liver right lobe of liver granulocyte trabecular bone blood bone marrow buccal mucosa cell bone marrow cells Top expressed in blood tibiofemoral joint spleen mesenteric lymph nodes granulocyte hepatobiliary system liver embryo right lung right lung lobe More reference expression data BioGPS More reference expression data
Gene ontology Molecular function protein binding carbohydrate binding transmembrane signaling receptor activity Cellular component integral component of membrane plasma membrane integral component of plasma membrane membrane Biological process platelet activation defense response cell surface receptor signaling pathway platelet formation signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 51266 56760 Ensembl ENSG00000165682 ENSMUSG00000030159 UniProt Q9P126 Q9JL99 RefSeq (mRNA) NM_001099431 NM_016509 NM_001393342 NM_001204239 NM_001204253 NM_019985 RefSeq (protein) NP_001092901 NP_057593 NP_001191168 NP_001191182 NP_064369 Location (UCSC) Chr 12: 9.99 – 10.01 Mb Chr 6: 129.37 – 129.39 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

C-type lectin domain family 1 member B (i.e., CLEC-1b), also termed C-type lectin-like receptor 2 (i.e., CLEC-2), ^[5] is a protein that in humans is encoded by the CLEC1B gene. ^{[6] [7] [8]}

Natural killer (NK) cells express multiple calcium-dependent (C-type) lectin-like receptors, such as CD94 (KLRD1; MIM 602894) and NKG2D (KLRC4; MIM 602893), that interact with major histocompatibility complex class I molecules and either inhibit or activate cytotoxicity and cytokine secretion. CLEC2 is a C-type lectin-like receptor expressed in myeloid cells and NK cells.[supplied by OMIM] ^[8]

References

1. GRCh38: Ensembl release 89: ENSG00000165682 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000030159 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Meng D, Luo M, Liu B (2021). "The Role of CLEC-2 and Its Ligands in Thromboinflammation". Frontiers in Immunology. 12: 688643. doi: 10.3389/fimmu.2021.688643 . PMC   8220156 . PMID   34177942.
6. Colonna M, Samaridis J, Angman L (Mar 2000). "Molecular characterization of two novel C-type lectin-like receptors, one of which is selectively expressed in human dendritic cells". Eur J Immunol. 30 (2): 697–704. doi: 10.1002/1521-4141(200002)30:2<697::AID-IMMU697>3.0.CO;2-M . PMID   10671229.
7. Sobanov Y, Bernreiter A, Derdak S, Mechtcheriakova D, Schweighofer B, Duchler M, Kalthoff F, Hofer E (Dec 2001). "A novel cluster of lectin-like receptor genes expressed in monocytic, dendritic and endothelial cells maps close to the NK receptor genes in the human NK gene complex". Eur J Immunol. 31 (12): 3493–503. doi:10.1002/1521-4141(200112)31:12<3493::AID-IMMU3493>3.0.CO;2-9. PMID   11745369. S2CID   42415487.
8. "Entrez Gene: CLEC1B C-type lectin domain family 1, member B".

External links

• Human CLEC1B genome location and CLEC1B gene details page in the UCSC Genome Browser .
• Human CLEC2B genome location and CLEC2B gene details page in the UCSC Genome Browser .

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Clark HF, Gurney AL, Abaya E, et al. (2003). "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC   403697 . PMID   12975309.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Suzuki-Inoue K, Fuller GL, García A, et al. (2006). "A novel Syk-dependent mechanism of platelet activation by the C-type lectin receptor CLEC-2". Blood. 107 (2): 542–9. doi:10.1182/blood-2005-05-1994. PMID   16174766. S2CID   168505.
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID   16189514. S2CID   4427026.
• Watson AA, O'Callaghan CA (2006). "Crystallization and X-ray diffraction analysis of human CLEC-2". Acta Crystallographica Section F. 61 (Pt 12): 1094–6. doi:10.1107/S1744309105037991. PMC   1978148 . PMID   16511244.
• Scherer SE, Muzny DM, Buhay CJ, et al. (2006). "The finished DNA sequence of human chromosome 12". Nature. 440 (7082): 346–51. Bibcode:2006Natur.440..346S. doi: 10.1038/nature04569 . PMID   16541075.
• Chaipan C, Soilleux EJ, Simpson P, et al. (2006). "DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets". J. Virol. 80 (18): 8951–60. doi:10.1128/JVI.00136-06. PMC   1563896 . PMID   16940507.
• Watson AA, Brown J, Harlos K, et al. (2007). "The crystal structure and mutational binding analysis of the extracellular domain of the platelet-activating receptor CLEC-2". J. Biol. Chem. 282 (5): 3165–72. doi: 10.1074/jbc.M610383200 . PMID   17132623.
• Suzuki-Inoue K, Kato Y, Inoue O, et al. (2007). "Involvement of the snake toxin receptor CLEC-2, in podoplanin-mediated platelet activation, by cancer cells". J. Biol. Chem. 282 (36): 25993–6001. doi: 10.1074/jbc.M702327200 . PMID   17616532.
• Watson AA, Eble JA, O'Callaghan CA (2008). "Crystal structure of rhodocytin, a ligand for the platelet-activating receptor CLEC-2". Protein Science. 17 (9): 1611–6. doi:10.1110/ps.035568.108. PMC   2525532 . PMID   18583525.