CLEC9A

CLEC9A
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	3VPP
Identifiers
Aliases	CLEC9A , DNGR1, UNQ9341, CD370, DNGR-1, C-type lectin domain family 9 member A, C-type lectin domain containing 9A
External IDs	OMIM: 612252 MGI: 2444608 HomoloGene: 52106 GeneCards: CLEC9A
Gene location (Human)
Chr.	Chromosome 12 (human)
End	10,066,031 bp
Gene location (Mouse)
Chr.	Chromosome 6 (mouse)
End	129,401,726 bp
RNA expression pattern
	Top expressed in
	lymph node; ; substantia nigra; ; monocyte; ; smooth muscle tissue; ; appendix; ; thymus; ; testicle; ; gallbladder; ; hypothalamus; ; duodenum;
	Top expressed in
	spleen; ; lung; ; liver; ; ovary; ; bone marrow; ; thymus; ; ileum; ; jejunum; ; colon; ; pancreas;
	More reference expression data
	n/a
Gene ontology
Molecular function	carbohydrate binding ;
Cellular component	integral component of membrane ; membrane ; cell surface ;
Biological process	endocytosis ; receptor-mediated endocytosis ;
	Sources:Amigo / QuickGO
Orthologs
	283420
	232414
	ENSG00000197992
	ENSMUSG00000046080
	Q6UXN8
	Q8BRU4
	NM_207345
	NM_001205363 ; NM_001205364 ; NM_001205365 ; NM_172732
	NP_997228
	NP_001192292 ; NP_001192293 ; NP_001192294 ; NP_766320
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated August 02, 2023

C-type lectin domain family 9 member A is a protein that in humans is encoded by the CLEC9A gene.^[5]

Function

CLEC9A is a group V C-type lectin-like receptor (CTLR) that functions as an activation receptor and is expressed on myeloid lineage cells (Huysamen et al., 2008 [PubMed 18408006]).^[6]

Related Research Articles

DC-SIGN also known as CD209 is a protein which in humans is encoded by the CD209 gene.

C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene. CLEC4M has also been designated as CD299.

Putative P2Y purinoceptor 10 is a protein that, in humans, is encoded by the P2RY10 gene.

C-type lectin domain family 7 member A or Dectin-1 is a protein that in humans is encoded by the CLEC7A gene. CLEC7A is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with a partial immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor for a variety of β-1,3-linked and β-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Expression is found on myeloid dendritic cells, monocytes, macrophages and B cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Tetranectin is a protein that in humans is encoded by the CLEC3B gene.

Killer cell lectin-like receptor subfamily B, member 1, also known as KLRB1, NKR-P1A or CD161, is a human gene.

C-type lectin domain family 11 member A is a protein that in humans is encoded by the CLEC11A gene.

Sialic acid-binding Ig-like lectin 9 is a protein that in humans is encoded by the SIGLEC9 gene.

C-type lectin domain family 1 member B is a protein that in humans is encoded by the CLEC1B gene.

Endosialin is a protein that in humans is encoded by the CD248 gene.

C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene.

C-type lectin domain family 4 member A is a protein that in humans is encoded by the CLEC4A gene.

C-type lectin domain family 1 member A is a protein that in humans is encoded by the CLEC1A gene.

C-type lectin domain family 2 member B is a protein that in humans is encoded by the CLEC2B gene.

C-type lectin domain family 12 member A is a protein that in humans is encoded by the CLEC12A gene.

The CD302 antigen also known as C-type lectin domain family 13 member A is a protein that in humans is encoded by the CD302 gene.

C-type lectin domain family 10 member A (CLEC10A) also designated as CD301 is a protein that in humans is encoded by the CLEC10A gene. CLEC10A is part of the C-type lectin superfamily and binds to N-Acetylgalactosamine (GalNAc). It is mainly expressed on myeloid cells and also on oocytes and very early stages of embryogenesis. CLEC10A is used as a marker of the CD1c⁺ dendritic cell subgroup, also called cDC2. The actions of CLEC10A are diverse, depending on the ligand and environment.

C-type lectin domain family 5 member A (CLEC5A), also known as C-type lectin superfamily member 5 (CLECSF5) and myeloid DAP12-associating lectin 1 (MDL-1) is a C-type lectin that in humans is encoded by the CLEC5A gene.

C-type lectin domain family 4 member F is a protein that in humans is encoded by the CLEC4F gene.

Dectin-2 or C-type lectin domain containing 6A is a protein that in humans is encoded by the CLEC6A gene. Dectin-2 is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded protein is a type II transmembrane protein with an extracellular carbohydrate recognition domain. It functions as a pattern recognition receptor recognizing α-mannans and as such plays an important role in innate immune response to fungi. Expression is found on macrophages and dendritic cells. It can also be found at low levels in Langerhans cells and peripheral blood monocytes, where expression levels could be increased upon induction of inflammation.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000197992 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046080 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Entrez Gene: C-type lectin domain family 9 member A" . Retrieved 2016-06-02.
↑ Zanders, Edward D. (2015-11-09). Human Drug Targets: A Compendium for Pharmaceutical Discovery. John Wiley & Sons. ISBN 978-1-118-84985-9.

External links

PDBe-KB provides an overview of all the structure information available in the PDB for Human C-type lectin domain family 9 member A (CLEC9A)

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

This article on a gene on human chromosome 12 is a stub. You can help Wikipedia by expanding it.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000197992 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000046080 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] "Entrez Gene: C-type lectin domain family 9 member A" . Retrieved 2016-06-02.

[6] Zanders, Edward D. (2015-11-09). Human Drug Targets: A Compendium for Pharmaceutical Discovery. John Wiley & Sons. ISBN 978-1-118-84985-9.

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v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1–50	CD1 a-c 1A 1B 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51–100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101–150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151–200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201–250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251–300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301–350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD327 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

CLEC9A

Contents

Function

Related Research Articles

References

Further reading

External links