CLEC2D

Last updated
CLEC2D
Available structures
PDB Human UniProt search: PDBe RCSB
Identifiers
Aliases CLEC2D , CLAX, LLT1, OCIL, C-type lectin domain family 2 member D
External IDs OMIM: 605659 HomoloGene: 137257 GeneCards: CLEC2D
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

n/a

RefSeq (protein)

NP_001004419
NP_001184246
NP_001184247
NP_001184248
NP_037401

Contents

n/a

Location (UCSC) Chr 12: 9.66 – 9.7 Mb n/a
PubMed search [2] n/a
Wikidata
View/Edit Human

C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene. [3]

This gene encodes a member of the natural killer cell receptor C-type lectin family. The encoded protein inhibits osteoclast formation and contains a transmembrane domain near the N-terminus as well as the C-type lectin-like extracellular domain. Several alternatively spliced transcript variants have been identified, but the full-length nature of every transcript has not been defined. [3] CLEC2D encodes the gene for the Lectin Like Transcript-1 (LLT1) protein which is a functional ligand for the human NKR-P1A receptor, encoded by the KLRB1 gene. In mice, there are many orthologs of the CLEC2D gene, and the presumed homolog is Clr-b/Ocil (Clec2d). Clr-b has been implicated in missing-self recognition by natural killer cells through engagement of the NKR-P1B receptor.

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C-type lectin domain family 10 member A (CLEC10A) also designated as CD301 is a protein that in humans is encoded by the CLEC10A gene. CLEC10A is part of the C-type lectin superfamily and binds to N-Acetylgalactosamine (GalNAc). It is mainly expressed on myeloid cells and also on oocytes and very early stages of embryogenesis. CLEC10A is used as a marker of the CD1c+ dendritic cell subgroup, also called cDC2. The actions of CLEC10A are diverse, depending on the ligand and environment.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000069493 - Ensembl, May 2017
  2. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  3. 1 2 "Entrez Gene: CLEC2D C-type lectin domain family 2, member D".

Further reading