REG4

REG4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2KV3
Identifiers
Aliases	REG4 , GISP, REG-IV, RELP, regenerating family member 4
External IDs	OMIM: 609846; MGI: 1914959; HomoloGene: 41671; GeneCards: REG4; OMA:REG4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p12 Start 119,794,017 bp [1] End 119,811,580 bp [1]
Gene location (Mouse) Chr. Chromosome 3 (mouse) [2] Band 3|3 F2.2 Start 98,129,472 bp [2] End 98,144,064 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of ileum duodenum jejunal mucosa body of pancreas mucosa of sigmoid colon rectum pancreatic ductal cell appendix testicle mucosa of transverse colon Top expressed in crypt of lieberkuhn of small intestine left colon Paneth cell duodenum ileum jejunum intestinal villus epithelium of small intestine migratory enteric neural crest cell embryo More reference expression data BioGPS n/a
Gene ontology Molecular function calcium ion binding heparin binding mannan binding carbohydrate binding transmembrane signaling receptor activity Cellular component cytoplasm extracellular region Biological process response to bacterium Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 83998 67709 Ensembl ENSG00000134193 ENSMUSG00000027876 UniProt Q9BYZ8 Q9D8G5 RefSeq (mRNA) NM_032044 NM_001159352 NM_001159353 NM_026328 RefSeq (protein) NP_001152824 NP_001152825 NP_114433 NP_080604 Location (UCSC) Chr 1: 119.79 – 119.81 Mb Chr 3: 98.13 – 98.14 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Regenerating islet-derived protein 4 (REG4) is a protein that in humans (Homo sapiens) is encoded by the REG4 gene. ^{[5] [6] [7]} REG4 is located on Chromosome 1 in humans and is expressed in the proximal gastrointestinal (GI) tract. ^[5]

References

1. GRCh38: Ensembl release 89: ENSG00000134193 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000027876 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Hartupee JC, Zhang H, Bonaldo MF, Soares MB, Dieckgraefe BK (Apr 2001). "Isolation and characterization of a cDNA encoding a novel member of the human regenerating protein family: Reg IV". Biochim Biophys Acta. 1518 (3): 287–93. doi:10.1016/s0167-4781(00)00284-0. PMID   11311942.
6. Violette S, Festor E, Pandrea-Vasile I, Mitchell V, Adida C, Dussaulx E, Lacorte JM, Chambaz J, Lacasa M, Lesuffleur T (Nov 2002). "Reg IV, a new member of the regenerating gene family, is overexpressed in colorectal carcinomas". Int J Cancer. 103 (2): 185–93. doi: 10.1002/ijc.10788 . PMID   12455032.
7. "Entrez Gene: REG4 regenerating islet-derived family, member 4".

Further reading

• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kämäräinen M, Heiskala K, Knuutila S, et al. (2003). "RELP, a Novel Human Reg-Like Protein with Up-Regulated Expression in Inflammatory and Metaplastic Gastrointestinal Mucosa". Am. J. Pathol. 163 (1): 11–20. doi:10.1016/S0002-9440(10)63625-5. PMC   1868159 . PMID   12819006.
• Zhang Y, Lai M, Lv B, et al. (2003). "Overexpression of Reg IV in colorectal adenoma". Cancer Lett. 200 (1): 69–76. doi:10.1016/S0304-3835(03)00460-9. PMID   14550954.
• Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi: 10.1038/ng1285 . PMID   14702039.
• Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC   2286551 . PMID   15340161.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Gu Z, Rubin MA, Yang Y, et al. (2005). "Reg IV: a promising marker of hormone refractory metastatic prostate cancer". Clin. Cancer Res. 11 (6): 2237–43. doi: 10.1158/1078-0432.CCR-04-0356 . PMID   15788672.
• Bishnupuri KS, Luo Q, Murmu N, et al. (2006). "Reg IV activates the epidermal growth factor receptor/Akt/AP-1 signaling pathway in colon adenocarcinomas". Gastroenterology. 130 (1): 137–49. doi:10.1053/j.gastro.2005.10.001. PMID   16401477.
• Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi: 10.1038/nature04727 . PMID   16710414.
• Takehara A, Eguchi H, Ohigashi H, et al. (2006). "Novel tumor marker REG4 detected in serum of patients with resectable pancreatic cancer and feasibility for antibody therapy targeting REG4". Cancer Sci. 97 (11): 1191–7. doi: 10.1111/j.1349-7006.2006.00297.x . PMC   11159249 . PMID   16918991.