CLEC2B

CLEC2B
Identifiers
Aliases	CLEC2B , AICL, CLECSF2, HP10085, IFNRG1, C-type lectin domain family 2 member B
External IDs	OMIM: 603242 HomoloGene: 68443 GeneCards: CLEC2B
Gene location (Human)
Chr.	Chromosome 12 (human)
End	9,869,386 bp
RNA expression pattern
	Top expressed in
	periodontal fiber; ; vena cava; ; pericardium; ; human penis; ; monocyte; ; vulva; ; gums; ; mucosa of urinary bladder; ; visceral pleura; ; skin of abdomen;
	n/a
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	carbohydrate binding ; identical protein binding ;
Cellular component	plasma membrane ; integral component of plasma membrane ; integral component of membrane ; membrane ;
Biological process	regulation of immune response ;
	Sources:Amigo / QuickGO
Orthologs
	9976
	n/a
	ENSG00000110852
	n/a
	Q92478
	n/a
	NM_005127
	n/a
	NP_005118
	n/a
	Wikidata
View/Edit Human

Last updated August 02, 2023

C-type lectin domain family 2 member B is a protein that in humans is encoded by the CLEC2B gene.^[3]^[4]

This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) protein superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The encoded type 2 transmembrane protein may function as a cell activation antigen. An alternative splice variant has been described but its full-length nucleotide sequence has not been determined. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.^[4]

Related Research Articles

C-type lectin domain family 4 member M is a protein that in humans is encoded by the CLEC4M gene. CLEC4M has also been designated as CD299.

C-type lectin domain family 7 member A or Dectin-1 is a protein that in humans is encoded by the CLEC7A gene. CLEC7A is a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. The encoded glycoprotein is a small type II membrane receptor with an extracellular C-type lectin-like domain fold and a cytoplasmic domain with a partial immunoreceptor tyrosine-based activation motif. It functions as a pattern-recognition receptor for a variety of β-1,3-linked and β-1,6-linked glucans from fungi and plants, and in this way plays a role in innate immune response. Expression is found on myeloid dendritic cells, monocytes, macrophages and B cells. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. This gene is closely linked to other CTL/CTLD superfamily members on chromosome 12p13 in the natural killer gene complex region.

Tetranectin is a protein that in humans is encoded by the CLEC3B gene.

Ficolin-3 is a protein that in humans is encoded by the FCN3 gene. Ficolin-3 was initially identified as H-ficolin, in which H is after the Hakata antigen that was previously found as an autoantigen in patients who lived in the city of Hakata.

ATP-binding cassette sub-family B member 9 is a protein that in humans is encoded by the ABCB9 gene.

Tetraspanin-13 is a protein that in humans is encoded by the TSPAN13 gene.

C-type lectin domain family 11 member A is a protein that in humans is encoded by the CLEC11A gene.

Tetraspanin-4 is a protein that in humans is encoded by the TSPAN4 gene.

C-type lectin domain family 1 member B is a protein that in humans is encoded by the CLEC1B gene.

Endosialin is a protein that in humans is encoded by the CD248 gene.

C-type lectin domain family 2 member D is a protein that in humans is encoded by the CLEC2D gene.

C-type lectin domain family 4 member A is a protein that in humans is encoded by the CLEC4A gene.

C-type lectin domain family 1 member A is a protein that in humans is encoded by the CLEC1A gene.

Signal-regulatory protein gamma is a protein that in humans is encoded by the SIRPG gene. SIRPG has also recently been designated CD172G.

Zinc finger protein 19 is a protein that in humans is encoded by the ZNF19 gene.

Cell surface A33 antigen is a protein that in humans is encoded by the GPA33 gene.

Chondrolectin is a protein that in humans is encoded by the CHODL gene. Mouse chondrolectin is encoded by Chodl.

C-type lectin domain family 12 member A is a protein that in humans is encoded by the CLEC12A gene.

The CD302 antigen also known as C-type lectin domain family 13 member A is a protein that in humans is encoded by the CD302 gene.

C-type lectin domain family 10 member A (CLEC10A) also designated as CD301 is a protein that in humans is encoded by the CLEC10A gene. CLEC10A is part of the C-type lectin superfamily and binds to N-Acetylgalactosamine (GalNAc). It is mainly expressed on myeloid cells and also on oocytes and very early stages of embryogenesis. CLEC10A is used as a marker of the CD1c⁺ dendritic cell subgroup, also called cDC2. The actions of CLEC10A are diverse, depending on the ligand and environment.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000110852 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Hamann J, Montgomery KT, Lau S, Kucherlapati R, van Lier RA (Mar 1997). "AICL: a new activation-induced antigen encoded by the human NK gene complex". Immunogenetics. 45 (5): 295–300. doi:10.1007/s002510050208. PMID 9038101. S2CID 34214844.
1 2 "Entrez Gene: CLEC2B C-type lectin domain family 2, member B".

External links

Human CLEC2B genome location and CLEC2B gene details page in the UCSC Genome Browser .

Drickamer K (1999). "C-type lectin-like domains". Curr. Opin. Struct. Biol. 9 (5): 585–90. doi:10.1016/S0959-440X(99)00009-3. PMID 10508765.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Ebner S, Sharon N, Ben-Tal N (2003). "Evolutionary analysis reveals collective properties and specificity in the C-type lectin and lectin-like domain superfamily". Proteins. 53 (1): 44–55. doi:10.1002/prot.10440. PMID 12945048. S2CID 30955198.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Renedo M, Arce I, Montgomery K, et al. (2000). "A sequence-ready physical map of the region containing the human natural killer gene complex on chromosome 12p12.3-p13.2". Genomics. 65 (2): 129–36. doi:10.1006/geno.2000.6163. PMID 10783260.
Yokoyama-Kobayashi M, Yamaguchi T, Sekine S, Kato S (1999). "Selection of cDNAs encoding putative type II membrane proteins on the cell surface from a human full-length cDNA bank". Gene. 228 (1–2): 161–7. doi:10.1016/S0378-1119(99)00004-9. PMID 10072769.
Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID 8889548.

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[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000110852 - Ensembl, May 2017

[2] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid9038101-3] Hamann J, Montgomery KT, Lau S, Kucherlapati R, van Lier RA (Mar 1997). "AICL: a new activation-induced antigen encoded by the human NK gene complex". Immunogenetics. 45 (5): 295–300. doi:10.1007/s002510050208. PMID 9038101. S2CID 34214844.

[entrez-4] 1 2 "Entrez Gene: CLEC2B C-type lectin domain family 2, member B".

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CLEC2B

Contents

Related Research Articles

References

External links

Further reading