Norwogonin

Norwogonin

Clinical data
Other names	5,7,8-Trihydroxyflavone; 5,7,8-THF
Identifiers
IUPAC name 5,7,8-trihydroxy-2-phenylchromen-4-one
CAS Number	4443-09-8
PubChem CID	5281674
ChemSpider	4444993
UNII	70U0WT21IB
KEGG	C10113
ChEBI	CHEBI:7642
ChEMBL	ChEMBL485250
CompTox Dashboard (EPA)	DTXSID20196171
Chemical and physical data
Formula	C15H10O5
Molar mass	270.240 g·mol−1
3D model (JSmol)	Interactive image
SMILES C1=CC=C(C=C1)C2=CC(=O)C3=C(O2)C(=C(C=C3O)O)O
InChI InChI=1S/C15H10O5/c16-9-6-11(18)14(19)15-13(9)10(17)7-12(20-15)8-4-2-1-3-5-8/h1-7,16,18-19H Key:ZFKKRRMUPBBYRS-UHFFFAOYSA-N

Norwogonin, also known as 5,7,8-trihydroxyflavone (5,7,8-THF), is a flavone, a naturally occurring flavonoid-like chemical compound which is found in Scutellaria baicalensis (Baikal skullcap). ^[1] It has been found to act as an agonist of the TrkB, the main signaling receptor of brain-derived neurotrophic factor (BDNF), and appears to possess roughly the same activity in this regard to that of the closely related but more well-known tropoflavin (7,8-DHF). ^[2]

See also

• Tropomyosin receptor kinase B § Agonists

References

1. Miyasaki Y, Rabenstein JD, Rhea J, Crouch ML, Mocek UM, Kittell PE, et al. (2013). Khan AU (ed.). "Isolation and characterization of antimicrobial compounds in plant extracts against multidrug-resistant Acinetobacter baumannii". PLOS ONE. 8 (4): e61594. Bibcode:2013PLoSO...861594M. doi: 10.1371/journal.pone.0061594 . PMC   3632535 . PMID   23630600.
2. Liu X, Chan CB, Jang SW, Pradoldej S, Huang J, He K, et al. (December 2010). "A synthetic 7,8-dihydroxyflavone derivative promotes neurogenesis and exhibits potent antidepressant effect". Journal of Medicinal Chemistry. 53 (23): 8274–86. doi:10.1021/jm101206p. PMC   3150605 . PMID   21073191.