Eupatilin

Last updated
Eupatilin
Eupatilin.svg
Eupatilin molecule ball.png
Clinical data
Dependence
liability
None
Routes of
administration
Oral
ATC code
  • none
Legal status
Legal status
  • CA:not available
  • UK:not available
  • US:not available
  • In general: ℞ (Prescription only)
Identifiers
  • 2-(3,4-Dimethoxyphenyl)-5,7-dihydroxy-6-methoxychromen-4-one
CAS Number
PubChem CID
ChemSpider
UNII
CompTox Dashboard (EPA)
Chemical and physical data
Formula C18H16O7
Molar mass 344.319 g·mol−1
3D model (JSmol)
  • O=C\1c3c(O)c(OC)c(O)cc3O/C(=C/1)c2ccc(OC)c(OC)c2
  • InChI=1S/C18H16O7/c1-22-12-5-4-9(6-14(12)23-2)13-7-10(19)16-15(25-13)8-11(20)18(24-3)17(16)21/h4-8,20-21H,1-3H3 X mark.svgN
  • Key:DRRWBCNQOKKKOL-UHFFFAOYSA-N X mark.svgN
 X mark.svgNYes check.svgY  (what is this?)    (verify)

Eupatilin (5,7-Dihydroxy-3',4',6-trimethoxyflavone) is an O-methylated flavone, a type of flavonoids. It can be found in Artemisia asiatica (Asteraceae). [1]

Related Research Articles

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Artemisia vulgaris, the common mugwort, is a species of flowering plant in the daisy family Asteraceae. It is one of several species in the genus Artemisia commonly known as mugwort, although Artemisia vulgaris is the species most often called mugwort. It is also occasionally known as riverside wormwood, felon herb, chrysanthemum weed, wild wormwood, old Uncle Henry, sailor's tobacco, naughty man, old man, or St. John's plant. Mugworts have been used medicinally and as culinary herbs.

<i>Artemisia annua</i> Herb known as sweet wormwood used to treat malaria

Artemisia annua, also known as sweet wormwood, sweet annie, sweet sagewort, annual mugwort or annual wormwood, is a common type of wormwood native to temperate Asia, but naturalized in many countries including scattered parts of North America.

<i>Sida cordifolia</i> Species of shrub

Sida cordifolia is a perennial subshrub of the mallow family Malvaceae native to India. It has naturalized throughout the world, and is considered an invasive weed in Africa, Australia, the southern United States, Hawaiian Islands, New Guinea, and French Polynesia. The specific name, cordifolia, refers to the heart-shaped leaf.

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<span class="mw-page-title-main">Apigenin</span> Chemical compound

Apigenin (4′,5,7-trihydroxyflavone), found in many plants, is a natural product belonging to the flavone class that is the aglycone of several naturally occurring glycosides. It is a yellow crystalline solid that has been used to dye wool.

<span class="mw-page-title-main">Kaempferol</span> Chemical compound

Kaempferol (3,4′,5,7-tetrahydroxyflavone) is a natural flavonol, a type of flavonoid, found in a variety of plants and plant-derived foods including kale, beans, tea, spinach, and broccoli. Kaempferol is a yellow crystalline solid with a melting point of 276–278 °C (529–532 °F). It is slightly soluble in water and highly soluble in hot ethanol, ethers, and DMSO. Kaempferol is named for 17th-century German naturalist Engelbert Kaempfer.

<span class="mw-page-title-main">Mugwort</span> Genus of flowering plants used as herbs

Mugwort or biboz is a common name for several species of aromatic flowering plants in the genus Artemisia. In Europe, mugwort most often refers to the species Artemisia vulgaris, or common mugwort. In East Asia the species Artemisia argyi is often called "Chinese mugwort" in the context of traditional Chinese medicine, or àicǎo (艾草) in Mandarin. Artemisia princeps is a mugwort known in Korea as ssuk (쑥) and in Japan as yomogi (ヨモギ). While other species are sometimes referred to by more specific common names, they may be called simply "mugwort" in many contexts.

<span class="mw-page-title-main">Baicalin</span> Chemical compound

As baicalin is a flavone glycoside, it is a flavonoid. It is the glucuronide of baicalein.

<span class="mw-page-title-main">Baicalein</span> Chemical compound

Baicalein (5,6,7-trihydroxyflavone) is a flavone, a type of flavonoid, originally isolated from the roots of Scutellaria baicalensis and Scutellaria lateriflora. It is also reported in Oroxylum indicum and Thyme. It is the aglycone of baicalin. Baicalein is one of the active ingredients of Sho-Saiko-To, which is a Chinese classic herbal formula, and listed in Japan as Kampo medicine. As a Chinese herbal supplement, it is believed to enhance liver health.

<span class="mw-page-title-main">Wogonin</span> Chemical compound

Wogonin is an O-methylated flavone, a flavonoid-like chemical compound which is found in Scutellaria baicalensis.

<span class="mw-page-title-main">Oroxylin A</span> Chemical compound

Oroxylin A is an O-methylated flavone, a chemical compound that can be found in the medicinal plants Scutellaria baicalensis and Scutellaria lateriflora, and the Oroxylum indicum tree. It has demonstrated activity as a dopamine reuptake inhibitor, and is also a negative allosteric modulator of the benzodiazepine site of the GABAA receptor. Oroxylin A has been found to improve memory consolidation in mice by elevating brain-derived neurotrophic factor (BDNF) levels in the hippocampus.

<span class="mw-page-title-main">Isovitexin</span> Chemical compound

Isovitexin is a flavone. the apigenin-6-C-glucoside. In this case, the prefix 'iso' does not imply an isoflavonoid, but the position of the glucoside on the flavone.

<span class="mw-page-title-main">6-Hydroxyflavone</span> Chemical compound

6-Hydroxyflavone is a flavone, a type of chemical compound. It is one of the noncompetitive inhibitors of cytochrome P450 2C9. It is reported in Crocus and leaves of Barleria prionitis Linn. . 6-Hydroxyflavone may have a potential as a therapeutic drug capable for the treatment of anxiety-like disorders.

<i>Artemisia herba-alba</i> Species of plant

Artemisia herba-alba, the white wormwood, is a perennial shrub in the genus Artemisia that grows commonly on the dry steppes of the Mediterranean regions in Northern Africa, Western Asia and Southwestern Europe. It is used as an antiseptic and antispasmodic in herbal medicine.

<span class="mw-page-title-main">Genkwanin</span> Chemical compound

Genkwanin is an O-methylated flavone, a type of flavonoid. It can be found in the seeds of Alnus glutinosa, and the leaves of the ferns Notholaena bryopoda and Asplenium normale and Aquilaria.

<i>Artemisia argyi</i> Species of mugwort daisy

Artemisia argyi, commonly known as silvery wormwood or Chinese mugwort, is a herbaceous perennial plant with a creeping rhizome. It is native to China, Korea, Mongolia, Japan, and the Russian Far East. It is known in Chinese as àicǎo or ài yè or ài hao, in Japanese as gaiyou and in Korean as hwanghae ssuk (황해쑥). It is used in herbal medicine for conditions of the liver, spleen and kidney.

<span class="mw-page-title-main">Hispidulin</span> Chemical compound

Hispidulin is a naturally occurring flavone with potential antiepileptic activity in rats and gerbils. It is found in plants including Grindelia argentina, Arrabidaea chica, Saussurea involucrate, Crossostephium chinense, Artemisia, and Salvia.

<span class="mw-page-title-main">Casticin</span> Chemical compound

Casticin is a methoxylated flavonol, meaning the core flavonoid structure has methyl groups attached. Found in Artemisia annua, the flavonoid has been shown to enhance the antimalarial activity of artemisinin though casticin itself has no direct antimalarial effects. It has been shown to have anti-mitotic activity. It is also found in Vitex agnus-castus.

<span class="mw-page-title-main">Chrysoeriol</span> Chemical compound

Chrysoeriol is a flavone, chemically the 3'-methoxy derivative of luteolin.

<span class="mw-page-title-main">Cirsilineol</span> Chemical compound

Cirsilineol is a bioactive flavone isolated from Artemisia and from Teucrium gnaphalodes.

References

  1. Kim DH, Na HK, Oh TY, Kim WB, Surh YJ (September 2004). "Eupatilin, a pharmacologically active flavone derived from Artemisia plants, induces cell cycle arrest in ras-transformed human mammary epithelial cells". Biochemical Pharmacology. 68 (6): 1081–7. doi:10.1016/j.bcp.2004.04.027. PMID   15313404.