FGF3

FGF3
Identifiers
Aliases	FGF3 , HBGF-3, INT2, fibroblast growth factor 3
External IDs	OMIM: 164950; MGI: 95517; HomoloGene: 3841; GeneCards: FGF3; OMA:FGF3 - orthologs
Gene location (Human)
Chr.	Chromosome 11 (human)
End	69,819,416 bp
Gene location (Mouse)
Chr.	Chromosome 7 (mouse)
End	144,398,173 bp
RNA expression pattern
	Top expressed in
	cerebellar hemisphere; ; right hemisphere of cerebellum; ; spinal cord; ; C1 segment; ; frontal lobe; ; Cortex of frontal lobe; ; ventricle; ; left ventricle; ; integument; ; dorsolateral prefrontal cortex;
	Top expressed in
	embryo; ; inner nuclear layer; ; tail of embryo; ; outer plexiform layer; ; primitive streak; ; endoderm; ; dental papilla; ; mesoderm; ; inner plexiform layer; ; morula;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	fibroblast growth factor receptor binding ; protein binding ; growth factor activity ; 1-phosphatidylinositol-3-kinase activity ; phosphatidylinositol-4,5-bisphosphate 3-kinase activity ; protein tyrosine kinase activity ;
Cellular component	extracellular region ; intracellular anatomical structure ;
Biological process	cell differentiation ; cell-cell signaling ; anatomical structure morphogenesis ; MAPK cascade ; multicellular organism development ; fibroblast growth factor receptor signaling pathway ; negative regulation of cardiac muscle tissue development ; positive regulation of cell population proliferation ; positive regulation of cell division ; signal transduction ; phosphatidylinositol phosphate biosynthetic process ; phosphatidylinositol-3-phosphate biosynthetic process ; peptidyl-tyrosine phosphorylation ; regulation of signaling receptor activity ; positive regulation of protein kinase B signaling ;
	Sources:Amigo / QuickGO
Orthologs
	2248
	14174
	ENSG00000186895
	ENSMUSG00000031074
	P11487
	n/a
	NM_005247
	NM_008007
	NP_005238
	n/a
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated November 28, 2024

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.^[5]

Function

FGF-3 is a member of the fibroblast growth factor family. FGF3 binds to Fibroblast Growth Factor Receptor 3 (FGFR3) to serve as a negative regulator of bone growth during ossification. Effectively, FGF-3 inhibits proliferation of chondrocytes within growth plate.

FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion.^[5]

Clinical significance

The FGF3 gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation.^[5] Also, haploinsufficiency in the FGF3 gene is thought to cause otodental syndrome.

Interactions

FGF3 (gene) has been shown to interact with EBNA1BP2.^[6]

Related Research Articles

Fibroblast growth factor receptor 2 (FGFR-2) also known as CD332 is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10. FGFR2 is a receptor for fibroblast growth factor.

The proto-oncogene c-Rel is a protein that in humans is encoded by the REL gene. The c-Rel protein is a member of the NF-κB family of transcription factors and contains a Rel homology domain (RHD) at its N-terminus and two C-terminal transactivation domains. c-Rel is a myeloid checkpoint protein that can be targeted for treating cancer. c-Rel has an important role in B-cell survival and proliferation. The REL gene is amplified or mutated in several human B-cell lymphomas, including diffuse large B-cell lymphoma and Hodgkin's lymphoma.

Fibroblast growth factor receptor 4 (FGFR-4) is a protein that in humans is encoded by the FGFR4 gene. FGFR4 has also been designated as CD334.

Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene.

Tyrosine-protein kinase Yes is a non-receptor tyrosine kinase that in humans is encoded by the YES1 gene.

Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene.

Fibroblast growth factor 8(FGF-8) is a protein that in humans is encoded by the FGF8 gene.

Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene.

Fibroblast growth factor 5 is a protein that in humans is encoded by the FGF5 gene.

Fibroblast growth factor 18 (FGF-18) is a protein that is encoded by the FGF18 gene in humans. The protein was first discovered in 1998, when two newly-identified murine genes Fgf17 and Fgf18 were described and confirmed as being closely related by sequence homology to Fgf8. The three proteins were eventually grouped into the FGF8 subfamily, which contains several of the endocrine FGF superfamily members FGF8, FGF17, and FGF18. Subsequent studies identified FGF18's role in promoting chondrogenesis, and an apparent specific activity for the generation of the hyaline cartilage in articular joints.

Fibroblast growth factor-binding protein 1 is a protein that in humans is encoded by the FGFBP1 gene.

Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF19 gene. It functions as a hormone, regulating bile acid synthesis, with effects on glucose and lipid metabolism. Reduced synthesis, and blood levels, may be a factor in chronic bile acid diarrhea and in certain metabolic disorders.

Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene.

Probable rRNA-processing protein EBP2 is a protein that in humans is encoded by the EBNA1BP2 gene.

Golgi apparatus protein 1 is a protein that in humans is encoded by the GLG1 gene.

Fibroblast growth factor 13 is a protein that in humans is encoded by the FGF13 gene.

Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene.

Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene.

Nucleoside diphosphate-linked moiety X motif 6 is a protein that in humans is encoded by the NUDT6 gene.

Fibroblast growth factor 17 is a protein that in humans is encoded by the FGF17 gene.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000186895 – Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031074 – Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
1 2 3 "Entrez Gene: FGF3 fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)".
↑ Reimers K, Antoine M, Zapatka M, Blecken V, Dickson C, Kiefer P (Aug 2001). "NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth". Mol. Cell. Biol. 21 (15): 4996–5007. doi:10.1128/MCB.21.15.4996-5007.2001. PMC 87226 . PMID 11438656.

Represa J, León Y, Miner C, Giraldez F (1991). "The int-2 proto-oncogene is responsible for induction of the inner ear". Nature. 353 (6344): 561–3. Bibcode:1991Natur.353..561R. doi:10.1038/353561a0. PMID 1922362. S2CID 1375659.
Brookes S, Smith R, Casey G, Dickson C, Peters G (1989). "Sequence organization of the human int-2 gene and its expression in teratocarcinoma cells". Oncogene. 4 (4): 429–36. PMID 2470007.
Casey G, Smith R, McGillivray D, Peters G, Dickson C (1987). "Characterization and chromosome assignment of the human homolog of int-2, a potential proto-oncogene". Mol. Cell. Biol. 6 (2): 502–10. doi:10.1128/mcb.6.2.502. PMC 367539 . PMID 3023852.
Mansour SL, Goddard JM, Capecchi MR (1993). "Mice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear". Development. 117 (1): 13–28. doi: 10.1242/dev.117.1.13 . PMID 8223243.
Ornitz DM, Xu J, Colvin JS, McEwen DG, MacArthur CA, Coulier F, Gao G, Goldfarb M (1996). "Receptor specificity of the fibroblast growth factor family". J. Biol. Chem. 271 (25): 15292–7. doi: 10.1074/jbc.271.25.15292 . PMID 8663044.
Galdemard C, Yamagata H, Brison O, Lavialle C (2000). "Regulation of FGF-3 gene expression in tumorigenic and non-tumorigenic clones of a human colon carcinoma cell line". J. Biol. Chem. 275 (23): 17364–73. doi: 10.1074/jbc.M909316199 . PMID 10749884.
Reimers K, Antoine M, Zapatka M, Blecken V, Dickson C, Kiefer P (2001). "NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth". Mol. Cell. Biol. 21 (15): 4996–5007. doi:10.1128/MCB.21.15.4996-5007.2001. PMC 87226 . PMID 11438656.
Popovici C, Conchonaud F, Birnbaum D, Roubin R (2004). "Functional phylogeny relates LET-756 to fibroblast growth factor 9". J. Biol. Chem. 279 (38): 40146–52. doi: 10.1074/jbc.M405795200 . PMID 15199049.
Antoine M, Reimers K, Wirz W, Gressner AM, Müller R, Kiefer P (2006). "Fibroblast growth factor 3, a protein with a dual subcellular fate, is interacting with human ribosomal protein S2". Biochem. Biophys. Res. Commun. 338 (2): 1248–55. doi:10.1016/j.bbrc.2005.10.079. PMID 16263090.
Tekin M, Hişmi BO, Fitoz S, Ozdağ H, Cengiz FB, Sirmaci A, Aslan I, Inceoğlu B, Yüksel-Konuk EB, Yilmaz ST, Yasun O, Akar N (2007). "Homozygous mutations in fibroblast growth factor 3 are associated with a new form of syndromic deafness characterized by inner ear agenesis, microtia, and microdontia". Am. J. Hum. Genet. 80 (2): 338–44. doi:10.1086/510920. PMC 1785350 . PMID 17236138.
Riley BM, Mansilla MA, Ma J, Daack-Hirsch S, Maher BS, Raffensperger LM, Russo ET, Vieira AR, Dodé C, Mohammadi M, Marazita ML, Murray JC (2007). "Impaired FGF signaling contributes to cleft lip and palate". Proc. Natl. Acad. Sci. U.S.A. 104 (11): 4512–7. Bibcode:2007PNAS..104.4512R. doi: 10.1073/pnas.0607956104 . PMC 1810508 . PMID 17360555.

This article on a gene on human chromosome 11 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000186895 – Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000031074 – Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[entrez-5] 1 2 3 "Entrez Gene: FGF3 fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)".

[pmid11438656-6] Reimers K, Antoine M, Zapatka M, Blecken V, Dickson C, Kiefer P (Aug 2001). "NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth". Mol. Cell. Biol. 21 (15): 4996–5007. doi:10.1128/MCB.21.15.4996-5007.2001. PMC 87226 . PMID 11438656.

[1]

[2]

[3]

[4]

[5]

[6]