EBNA1BP2

EBNA1BP2
Identifiers
Aliases	EBNA1BP2 , EBP2, NOBP, P40, EBNA1 binding protein 2
External IDs	OMIM: 614443 MGI: 1916322 HomoloGene: 4969 GeneCards: EBNA1BP2
Gene location (Human)
Chr.	Chromosome 1 (human)
End	43,270,936 bp
Gene location (Mouse)
Chr.	Chromosome 4 (mouse)
End	118,484,973 bp
RNA expression pattern
	Top expressed in
	right lobe of liver; ; anterior pituitary; ; Achilles tendon; ; islet of Langerhans; ; Brodmann area 9; ; right uterine tube; ; cingulate gyrus; ; body of pancreas; ; rectum; ; right adrenal gland;
	Top expressed in
	otic placode; ; primitive streak; ; morula; ; somite; ; abdominal wall; ; ganglionic eminence; ; yolk sac; ; saccule; ; lens; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	RNA binding ; protein binding ;
Cellular component	nucleus ; nuclear periphery ; preribosome, large subunit precursor ; nucleolus ;
Biological process	ribosome biogenesis ; ribosomal large subunit biogenesis ; rRNA processing ;
	Sources:Amigo / QuickGO
Orthologs
	10969
	69072
	ENSG00000117395
	ENSMUSG00000028729
	Q99848 ; Q6IB29
	Q9D903
	NM_006824 ; NM_001159936
	NM_026932
	NP_001153408 ; NP_006815 ; NP_006815.2
	NP_081208
	Wikidata
View/Edit Human	View/Edit Mouse

Last updated March 29, 2024

Probable rRNA-processing protein EBP2 is a protein that in humans is encoded by the EBNA1BP2 gene.^[5]^[6]^[7]

Interactions

EBNA1BP2 has been shown to interact with FGF3.^[6]

Related Research Articles

The Epstein–Barr virus (EBV), formally called Human gammaherpesvirus 4, is one of the nine known human herpesvirus types in the herpes family, and is one of the most common viruses in humans. EBV is a double-stranded DNA virus. Epstein–Barr virus (EBV) is the first identified oncogenic virus, which establishes permanent infection in humans. EBV causes infectious mononucleosis and is also tightly linked to many malignant diseases. Various vaccine formulations underwent testing in different animals or in humans. However, none of them were able to prevent EBV infection and no vaccine has been approved to date.

INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.

Complement receptor type 2 (CR2), also known as complement C3d receptor, Epstein-Barr virus receptor, and CD21, is a protein that in humans is encoded by the CR2 gene.

Replication protein A 70 kDa DNA-binding subunit is a protein that in humans is encoded by the RPA1 gene.

DNA-directed RNA polymerase II subunit RPB4 is an enzyme that in humans is encoded by the POLR2D gene.

Y box binding protein 1 also known as Y-box transcription factor or nuclease-sensitive element-binding protein 1 is a protein that in humans is encoded by the YBX1 gene.

G-protein coupled receptor 183 also known as Epstein-Barr virus-induced G-protein coupled receptor 2 (EBI2) is a protein (GPCR) expressed on the surface of some immune cells, namely B cells and T cells; in humans it is encoded by the GPR183 gene. Expression of EBI2 is one critical mediator of immune cell localization within lymph nodes, responsible in part for the coordination of B cell, T cell, and dendritic cell movement and interaction following antigen exposure. EBI2 is a receptor for oxysterols. The most potent activator is 7α,25-dihydroxycholesterol (7α,25-OHC), with other oxysterols exhibiting varying affinities for the receptor. Oxysterol gradients drive chemotaxis, attracting the EBI2-expressing cells to locations of high ligand concentration. The GPR183 gene was identified due to its upregulation during Epstein-Barr virus infection of the Burkitt's lymphoma cell line BL41, hence its name: EBI2.

ELAV-like protein 1 or HuR is a protein that in humans is encoded by the ELAVL1 gene.

Interferon-induced GTP-binding protein Mx1 is a protein that in humans is encoded by the MX1 gene.

Recombination signal binding protein for immunoglobulin kappa J region is a protein that in humans is encoded by the RBPJ gene.

Insulin-like growth factor 2 mRNA-binding protein 1 is a protein that in humans is encoded by the IGF2BP1 gene.

Ubiquitin-specific-processing protease 7 (USP7), also known as ubiquitin carboxyl-terminal hydrolase 7 or herpesvirus-associated ubiquitin-specific protease (HAUSP), is an enzyme that in humans is encoded by the USP7 gene.

HuD otherwise known as ELAV-like protein 4 is a protein that in humans is encoded by the ELAVL4 gene.

SLAM family member 6 is a protein that in humans is encoded by the SLAMF6 gene.

Zinc finger protein 40 is a protein that in humans is encoded by the HIVEP1 gene.

SP110 nuclear body protein is a protein that in humans is encoded by the SP110 gene.

RNA-binding protein Raly is a protein that in humans is encoded by the RALY gene.

Tankyrase-2 is an enzyme that in humans is encoded by the TNKS2 gene.

Serine/threonine-protein kinase VRK2 is an enzyme that in humans is encoded by the VRK2 gene.

The Epstein–Barr virus nuclear antigen 2 (EBNA-2) is one of the six EBV viral nuclear proteins expressed in latently infected B lymphocytes is a transactivator protein. EBNA2 is involved in the regulation of latent viral transcription and contributes to the immortalization of EBV infected cells. EBNA2 acts as an adapter molecule that binds to cellular sequence-specific DNA-binding proteins, JK recombination signal-binding protein (RBP-JK), and PU.1 as well as working with multiple members of the RNA polymerase II transcription complex.

References

1 2 3 GRCh38: Ensembl release 89: ENSG00000117395 - Ensembl, May 2017
1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028729 - Ensembl, May 2017
↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
↑ Shire K, Ceccarelli DF, Avolio-Hunter TM, Frappier L (May 1999). "EBP2, a human protein that interacts with sequences of the Epstein-Barr virus nuclear antigen 1 important for plasmid maintenance". J Virol. 73 (4): 2587–95. doi:10.1128/JVI.73.4.2587-2595.1999. PMC 104013 . PMID 10074103.
1 2 Reimers K, Antoine M, Zapatka M, Blecken V, Dickson C, Kiefer P (Jul 2001). "NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth". Mol Cell Biol. 21 (15): 4996–5007. doi:10.1128/MCB.21.15.4996-5007.2001. PMC 87226 . PMID 11438656.
↑ "Entrez Gene: EBNA1BP2 EBNA1 binding protein 2".

Chatterjee A, Freeman JW, Busch H (1987). "Identification and partial characterization of a Mr 40,000 nucleolar antigen associated with cell proliferation". Cancer Res. 47 (4): 1123–9. PMID 2879624.
Sherrington R, Rogaev EI, Liang Y, et al. (1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease". Nature. 375 (6534): 754–60. Bibcode:1995Natur.375..754S. doi:10.1038/375754a0. PMID 7596406. S2CID 4308372.
Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Huber MD, Dworet JH, Shire K, et al. (2000). "The budding yeast homolog of the human EBNA1-binding protein 2 (Ebp2p) is an essential nucleolar protein required for pre-rRNA processing". J. Biol. Chem. 275 (37): 28764–73. doi: 10.1074/jbc.M000594200 . PMID 10849420.
Henning D, Valdez BC (2001). "Expression of p40/Epstein-Barr virus nuclear antigen 1 binding protein 2". Biochem. Biophys. Res. Commun. 283 (2): 430–6. doi:10.1006/bbrc.2001.4780. PMID 11327720.
Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID 11790298. S2CID 14132033.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC 139241 . PMID 12477932.
Kapoor P, Frappier L (2003). "EBNA1 partitions Epstein-Barr virus plasmids in yeast cells by attaching to human EBNA1-binding protein 2 on mitotic chromosomes". J. Virol. 77 (12): 6946–56. doi:10.1128/JVI.77.12.6946-6956.2003. PMC 156160 . PMID 12768013.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928 . PMID 15489334.
Kapoor P, Lavoie BD, Frappier L (2005). "EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases". Mol. Cell. Biol. 25 (12): 4934–45. doi:10.1128/MCB.25.12.4934-4945.2005. PMC 1140579 . PMID 15923612.
Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC 1847948 . PMID 17353931.

This article on a gene on human chromosome 1 is a stub. You can help Wikipedia by expanding it.

This page is based on this Wikipedia article
Text is available under the CC BY-SA 4.0 license; additional terms may apply.
Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] 1 2 3 GRCh38: Ensembl release 89: ENSG00000117395 - Ensembl, May 2017

[refGRCm38Ensembl-2] 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000028729 - Ensembl, May 2017

[3] "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid10074103-5] Shire K, Ceccarelli DF, Avolio-Hunter TM, Frappier L (May 1999). "EBP2, a human protein that interacts with sequences of the Epstein-Barr virus nuclear antigen 1 important for plasmid maintenance". J Virol. 73 (4): 2587–95. doi:10.1128/JVI.73.4.2587-2595.1999. PMC 104013 . PMID 10074103.

[pmid11438656-6] 1 2 Reimers K, Antoine M, Zapatka M, Blecken V, Dickson C, Kiefer P (Jul 2001). "NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth". Mol Cell Biol. 21 (15): 4996–5007. doi:10.1128/MCB.21.15.4996-5007.2001. PMC 87226 . PMID 11438656.

[entrez-7] "Entrez Gene: EBNA1BP2 EBNA1 binding protein 2".

[1]

[2]

[3]

[4]

[5]

[6]

[7]

EBNA1BP2

Contents

Interactions

Related Research Articles

References

Further reading