EBNA1BP2

EBNA1BP2
Identifiers
Aliases	EBNA1BP2 , EBP2, NOBP, P40, EBNA1 binding protein 2
External IDs	OMIM: 614443; MGI: 1916322; HomoloGene: 4969; GeneCards: EBNA1BP2; OMA:EBNA1BP2 - orthologs
Gene location (Human) Chr. Chromosome 1 (human) [1] Band 1p34.2 Start 43,164,175 bp [1] End 43,270,936 bp [1]
Gene location (Mouse) Chr. Chromosome 4 (mouse) [2] Band 4|4 D2.1 Start 118,477,996 bp [2] End 118,484,973 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in right lobe of liver anterior pituitary tendon of biceps brachii right testis left testis right frontal lobe Achilles tendon islet of Langerhans Brodmann area 9 olfactory zone of nasal mucosa Top expressed in tail of embryo genital tubercle otic placode epiblast embryo ventricular zone embryo morula primitive streak somite More reference expression data BioGPS More reference expression data
Gene ontology Molecular function RNA binding protein binding Cellular component nucleus nuclear periphery preribosome, large subunit precursor nucleolus Biological process ribosome biogenesis ribosomal large subunit biogenesis rRNA processing Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10969 69072 Ensembl ENSG00000117395 ENSMUSG00000028729 UniProt Q99848 Q6IB29 Q9D903 RefSeq (mRNA) NM_006824 NM_001159936 NM_026932 RefSeq (protein) NP_001153408 NP_006815 NP_006815.2 NP_081208 Location (UCSC) Chr 1: 43.16 – 43.27 Mb Chr 4: 118.48 – 118.48 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Probable rRNA-processing protein EBP2 is a protein that in humans is encoded by the EBNA1BP2 gene. ^{[5] [6] [7]}

Interactions

EBNA1BP2 has been shown to interact with FGF3. ^[6]

References

1. GRCh38: Ensembl release 89: ENSG00000117395 – Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000028729 – Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. Shire K, Ceccarelli DF, Avolio-Hunter TM, Frappier L (May 1999). "EBP2, a human protein that interacts with sequences of the Epstein-Barr virus nuclear antigen 1 important for plasmid maintenance". J Virol. 73 (4): 2587–95. doi:10.1128/JVI.73.4.2587-2595.1999. PMC   104013 . PMID   10074103.
6. Reimers K, Antoine M, Zapatka M, Blecken V, Dickson C, Kiefer P (Jul 2001). "NoBP, a nuclear fibroblast growth factor 3 binding protein, is cell cycle regulated and promotes cell growth". Mol Cell Biol. 21 (15): 4996–5007. doi:10.1128/MCB.21.15.4996-5007.2001. PMC   87226 . PMID   11438656.
7. "Entrez Gene: EBNA1BP2 EBNA1 binding protein 2".

Further reading

• Chatterjee A, Freeman JW, Busch H (1987). "Identification and partial characterization of a Mr 40,000 nucleolar antigen associated with cell proliferation". Cancer Res. 47 (4): 1123–9. PMID   2879624.
• Sherrington R, Rogaev EI, Liang Y, et al. (1995). "Cloning of a gene bearing missense mutations in early-onset familial Alzheimer's disease". Nature. 375 (6534): 754–60. Bibcode:1995Natur.375..754S. doi:10.1038/375754a0. PMID   7596406. S2CID   4308372.
• Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID   8125298.
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID   9373149.
• Huber MD, Dworet JH, Shire K, et al. (2000). "The budding yeast homolog of the human EBNA1-binding protein 2 (Ebp2p) is an essential nucleolar protein required for pre-rRNA processing". J. Biol. Chem. 275 (37): 28764–73. doi: 10.1074/jbc.M000594200 . PMID   10849420.
• Henning D, Valdez BC (2001). "Expression of p40/Epstein-Barr virus nuclear antigen 1 binding protein 2". Biochem. Biophys. Res. Commun. 283 (2): 430–6. doi:10.1006/bbrc.2001.4780. PMID   11327720.
• Andersen JS, Lyon CE, Fox AH, et al. (2002). "Directed proteomic analysis of the human nucleolus". Curr. Biol. 12 (1): 1–11. Bibcode:2002CBio...12....1A. doi: 10.1016/S0960-9822(01)00650-9 . PMID   11790298. S2CID   14132033.
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi: 10.1073/pnas.242603899 . PMC   139241 . PMID   12477932.
• Kapoor P, Frappier L (2003). "EBNA1 partitions Epstein-Barr virus plasmids in yeast cells by attaching to human EBNA1-binding protein 2 on mitotic chromosomes". J. Virol. 77 (12): 6946–56. doi:10.1128/JVI.77.12.6946-6956.2003. PMC   156160 . PMID   12768013.
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC   528928 . PMID   15489334.
• Kapoor P, Lavoie BD, Frappier L (2005). "EBP2 plays a key role in Epstein-Barr virus mitotic segregation and is regulated by aurora family kinases". Mol. Cell. Biol. 25 (12): 4934–45. doi:10.1128/MCB.25.12.4934-4945.2005. PMC   1140579 . PMID   15923612.
• Ewing RM, Chu P, Elisma F, et al. (2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi:10.1038/msb4100134. PMC   1847948 . PMID   17353931.