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FGF1, also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1 gene. It is synthesized as a 155 amino acid polypeptide, whose mature form is a non-glycosylated 17-18 kDa protein. Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated acidic FGF, Heparin-binding growth factor-1, and Endothelial cell growth factor-1. Gene sequencing revealed that this group was actually the same growth factor and that FGF1 was a member of a family of FGF proteins.
INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene.
Fibroblast growth factor receptor 2 (FGFR2) also known as CD332 is a protein that in humans is encoded by the FGFR2 gene residing on chromosome 10. FGFR2 is a receptor for fibroblast growth factor.
Fibroblast growth factor receptor 1 (FGFR1), also known as basic fibroblast growth factor receptor 1, fms-related tyrosine kinase-2 / Pfeiffer syndrome, and CD331, is a receptor tyrosine kinase whose ligands are specific members of the fibroblast growth factor family. FGFR1 has been shown to be associated with Pfeiffer syndrome, and clonal eosinophilias.
Fibroblast growth factor receptor 3 is a protein that in humans is encoded by the FGFR3 gene. FGFR3 has also been designated as CD333. The gene, which is located on chromosome 4, location q16.3, is expressed in tissues such as the cartilage, brain, intestine, and kidneys.
Keratinocyte growth factor is a protein that in humans is encoded by the FGF7 gene.
Fibroblast growth factor 10 is a protein that in humans is encoded by the FGF10 gene.
Fibroblast growth factor 8(FGF-8) is a protein that in humans is encoded by the FGF8 gene.
Glia-activating factor is a protein that in humans is encoded by the FGF9 gene.
Fibroblast growth factor 4 is a protein that in humans is encoded by the FGF4 gene.
Fibroblast growth factor 5 is a protein that in humans is encoded by the FGF5 gene.
Fibroblast growth factor 18 is a protein that in humans is encoded by the FGF18 gene.
Fibroblast growth factor 14 is a biologically active protein that in humans is encoded by the FGF14 gene.
Fibroblast growth factor 13 is a protein that in humans is encoded by the FGF13 gene.
Fibroblast growth factor 6 is a protein that in humans is encoded by the FGF6 gene.
Fibroblast growth factor 12 is a protein that in humans is encoded by the FGF12 gene.
Fibroblast growth factor 17 is a protein that in humans is encoded by the FGF17 gene.
Fibroblast growth factor 22 is a protein which in humans is encoded by the FGF22 gene.
Fibroblast growth factor 20 is a protein which in humans is encoded by the FGF20 gene.
References
- ↑ Miyake A, Konishi M, Martin FH, Hernday NA, Ozaki K, Yamamoto S, Mikami T, Arakawa T, Itoh N (February 1998). "Structure and expression of a novel member, FGF-16, on the fibroblast growth factor family". Biochemical and Biophysical Research Communications. 243 (1): 148–52. doi:10.1006/bbrc.1998.8073. PMID 9473496.
- ↑ Kim HS (2001). "The human FGF gene family: chromosome location and phylogenetic analysis". Cytogenetics and Cell Genetics. 93 (1–2): 131–2. doi:10.1159/000056965. PMID 11474196. S2CID 20876318.
- ↑ "Entrez Gene: Fibroblast growth factor 16".
- ↑ Jamsheer A, Zemojtel T, Kolanczyk M, Stricker S, Hecht J, Krawitz P, Doelken SC, Glazar R, Socha M, Mundlos S (September 2013). "Whole exome sequencing identifies FGF16 nonsense mutations as the cause of X-linked recessive metacarpal 4/5 fusion". Journal of Medical Genetics. 50 (9): 579–84. doi:10.1136/jmedgenet-2013-101659. PMID 23709756. S2CID 9501794.
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
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