Angiopoietin 1

Last updated
ANGPT1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ANGPT1 , AGP1, AGPT, ANG1, angiopoietin 1, HAE5, AGPT-1
External IDs OMIM: 601667; MGI: 108448; HomoloGene: 37447; GeneCards: ANGPT1; OMA:ANGPT1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001146
NM_001199859
NM_001314051
NM_139290

NM_009640
NM_001286062

RefSeq (protein)

NP_001137
NP_001186788
NP_001300980

NP_001272991
NP_033770

Location (UCSC) Chr 8: 107.25 – 107.5 Mb Chr 15: 42.29 – 42.54 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1.

Contents

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. [5] During pregnancy, angiopoietins act complementary to the VEGF system and contribute to endothelial cell survival and the remodeling of vessels. Few studies have examined the role of angiopoietins in human pregnancy complications like preeclampsia and intrauterine growth restriction (IUGR).

A knockout model of ANGPT1 was introduced in mice embryos. Results showed that embryos began to appear abnormal by day 11 and were dead by day 12.5 of pregnancy. The embryos showed prominent defects in endocardial and myocardial development as well as a less complex vascular network.

[6] [7]

Interactions

Angiopoietin 1 has been shown to interact with TEK tyrosine kinase. [8] [9] [10] [11]

Placental Malaria

Recently, studies in malaria-endemic areas suggest that placental malaria (PM) may be associated with a dysregulation in angiopoietins. Increased levels of angiopoietin-1 appear to be associated with a decrease in placental weight and placental barrier thickness in women infected with Plasmodium (the causative agent of malaria). [12] In a mouse model of PM, Plasmodium infection of pregnant mice led to decreased angiopoietin-1, increased angiopoietin-2, and an elevated ratio of angiopoietin-2/angiopoietin-1 in the placenta. [13] This suggests that angiopoietin levels could be clinically significant biomarkers to identify mothers infected with PM.

See also

Related Research Articles

<span class="mw-page-title-main">Endostatin</span>

Endostatin is a naturally occurring, 20-kDa C-terminal fragment derived from type XVIII collagen. It is reported to serve as an anti-angiogenic agent, similar to angiostatin and thrombospondin.

<span class="mw-page-title-main">George Yancopoulos</span> American biomedical scientist (born 1959)

George D. Yancopoulos is a Greek-American biomedical scientist who is the co-founder, president and chief scientific officer of Regeneron Pharmaceuticals.

<span class="mw-page-title-main">Tropomyosin receptor kinase B</span> Protein and coding gene in humans

Tropomyosin receptor kinase B (TrkB), also known as tyrosine receptor kinase B, or BDNF/NT-3 growth factors receptor or neurotrophic tyrosine kinase, receptor, type 2 is a protein that in humans is encoded by the NTRK2 gene. TrkB is a receptor for brain-derived neurotrophic factor (BDNF). The standard pronunciation for this protein is "track bee".

<span class="mw-page-title-main">Ephrin receptor</span> Protein family

Eph receptors are a group of receptors that are activated in response to binding with Eph receptor-interacting proteins (Ephrins). Ephs form the largest known subfamily of receptor tyrosine kinases (RTKs). Both Eph receptors and their corresponding ephrin ligands are membrane-bound proteins that require direct cell-cell interactions for Eph receptor activation. Eph/ephrin signaling has been implicated in the regulation of a host of processes critical to embryonic development including axon guidance, formation of tissue boundaries, cell migration, and segmentation. Additionally, Eph/ephrin signaling has been identified to play a critical role in the maintenance of several processes during adulthood including long-term potentiation, angiogenesis, and stem cell differentiation and cancer.

<span class="mw-page-title-main">Neurotrophin-3</span> Protein-coding gene in the species Homo sapiens

Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene.

<span class="mw-page-title-main">Angiopoietin</span> Protein family

Angiopoietin is part of a family of vascular growth factors that play a role in embryonic and postnatal angiogenesis. Angiopoietin signaling most directly corresponds with angiogenesis, the process by which new arteries and veins form from preexisting blood vessels. Angiogenesis proceeds through sprouting, endothelial cell migration, proliferation, and vessel destabilization and stabilization. They are responsible for assembling and disassembling the endothelial lining of blood vessels. Angiopoietin cytokines are involved with controlling microvascular permeability, vasodilation, and vasoconstriction by signaling smooth muscle cells surrounding vessels. There are now four identified angiopoietins: ANGPT1, ANGPT2, ANGPTL3, ANGPT4.

<span class="mw-page-title-main">Glycoprotein 130</span> Mammalian protein found in Homo sapiens

Glycoprotein 130 is a transmembrane protein which is the founding member of the class of tall cytokine receptors. It forms one subunit of the type I cytokine receptor within the IL-6 receptor family. It is often referred to as the common gp130 subunit, and is important for signal transduction following cytokine engagement. As with other type I cytokine receptors, gp130 possesses a WSXWS amino acid motif that ensures correct protein folding and ligand binding. It interacts with Janus kinases to elicit an intracellular signal following receptor interaction with its ligand. Structurally, gp130 is composed of five fibronectin type-III domains and one immunoglobulin-like C2-type (immunoglobulin-like) domain in its extracellular portion.

The angiopoietin receptors are receptors that bind angiopoietin. TIE-1 and TIE-2 comprise the cell-surface receptors that bind and are activated by the angiopoietins,. The angiopoietins are protein growth factors required for the formation of blood vessels (angiogenesis).

<span class="mw-page-title-main">ANGPT2</span> Protein-coding gene in the species Homo sapiens

Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene.

<span class="mw-page-title-main">GRB10</span> Protein-coding gene in the species Homo sapiens

Growth factor receptor-bound protein 10 also known as insulin receptor-binding protein Grb-IR is a protein that in humans is encoded by the GRB10 gene.

<span class="mw-page-title-main">VEGFR1</span> Protein-coding gene in the species Homo sapiens

Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.

<span class="mw-page-title-main">Ephrin B2</span> Protein-coding gene in the species Homo sapiens

Ephrin-B2 is a protein that in humans is encoded by the EFNB2 gene.

<span class="mw-page-title-main">TEK tyrosine kinase</span> Protein-coding gene in the species Homo sapiens

Angiopoietin-1 receptor also known as CD202B is a protein that in humans is encoded by the TEK gene. Also known as TIE2, it is an angiopoietin receptor.

<span class="mw-page-title-main">EPH receptor A2</span> Protein-coding gene in humans

EPH receptor A2 is a protein that in humans is encoded by the EPHA2 gene.

<span class="mw-page-title-main">EPH receptor B1</span> Protein-coding gene in the species Homo sapiens

Ephrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene.

<span class="mw-page-title-main">Discoidin domain-containing receptor 2</span> Protein-coding gene in the species Homo sapiens

Discoidin domain-containing receptor 2, also known as CD167b, is a protein that in humans is encoded by the DDR2 gene. Discoidin domain-containing receptor 2 is a receptor tyrosine kinase (RTK).

<span class="mw-page-title-main">GRLF1</span> Protein-coding gene in the species Homo sapiens

Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene.

<span class="mw-page-title-main">ANGPT4</span> Protein-coding gene in the species Homo sapiens

Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene.

<span class="mw-page-title-main">Vascular endothelial growth factor A</span> Protein involved in blood vessel growth

Vascular endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene.

Thomas N. Sato is a prominent Japanese educator, entrepreneur, and biologist, whose research focuses on understanding molecular basis of cancer, cardiac disease and metabolic diseases by using a number of animal models including mice, zebrafish and fruit flies. He is also working to invent next-generation therapeutics for human diseases based on the stochastic basis of life and disease. He is currently director of the Thomas N. Sato BioMEC-X Laboratories at the Advanced Telecommunications Research Institute International (ATR) in Kyoto, research director of the ERATO Sato Live Bio-forecasting project JST in Kyoto, scientific founder and chair of board of directors Karydo TherapeutiX, Inc, professor of Virtual Human InformatiX Clinic in Nara, and affiliate professor at Centenary Institute in Sydney, Australia. He is also a triathlete who competes at Ironman distance including Ironman Lake Placid, Ironman Japan, Ironman Coeur d’Alene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000154188 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022309 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ANGPT1 angiopoietin 1".
  6. Suri, Chitra; Jones, Pamela F; Patan, Sybill; Bartunkova, Sona; Maisonpierre, Peter C; Davis, Samuel; Sato, Thomas N; Yancopoulos, George D (1996). "Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis". Cell. 87 (7): 1171–80. doi: 10.1016/S0092-8674(00)81813-9 . PMID   8980224. S2CID   15926708.
  7. Kappou D, Sifakis S, Konstantinidou A, et al. Role of angiopoietin/Tie system in pregnancy.Experimental and Therapeutic Medicine. 2015; 9(4): 1091-1096.
  8. Fiedler, Ulrike; Krissl, Tanja; Koidl, Stefanie; Weiss, Cornelia; Koblizek, Thomas; Deutsch, Urban; Martiny-Baron, Georg; Marmé, Dieter; Augustin, Hellmut G (Jan 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". J. Biol. Chem. 278 (3). United States: 1721–7. doi: 10.1074/jbc.M208550200 . ISSN   0021-9258. PMID   12427764.
  9. Davis, S; Aldrich, T H; Jones, P F; Acheson, A; Compton, D L; Jain, V; Ryan, T E; Bruno, J; Radziejewski, C; Maisonpierre, P C; Yancopoulos, G D (Dec 1996). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell. 87 (7). United States: 1161–9. doi: 10.1016/S0092-8674(00)81812-7 . ISSN   0092-8674. PMID   8980223. S2CID   17197564.
  10. Sato, A; Iwama A; Takakura N; Nishio H; Yancopoulos G D; Suda T (Aug 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". Int. Immunol. 10 (8). ENGLAND: 1217–27. doi: 10.1093/intimm/10.8.1217 . ISSN   0953-8178. PMID   9723709.
  11. Maisonpierre, P C; Suri, C; Jones, P F; Bartunkova, S; Wiegand, S J; Radziejewski, C; Compton, D; McClain, J; Aldrich, T H; Papadopoulos, N; Daly, T J; Davis, S; Sato, T N; Yancopoulos, G D (Jul 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science . 277 (5322). UNITED STATES: 55–60. doi:10.1126/science.277.5322.55. ISSN   0036-8075. PMID   9204896.
  12. Ataíde, Ricardo; Murillo, Oscar; Dombrowski, Jamille G.; Souza, Rodrigo M.; Lima, Flávia A.; Lima, Giselle F. M. C.; Hristov, Angélica D.; Valle, Suiane C. N.; Santi, Silvia M. Di (2015-06-19). "Malaria in Pregnancy Interacts with and Alters the Angiogenic Profiles of the Placenta". PLOS Neglected Tropical Diseases. 9 (6): e0003824. doi: 10.1371/journal.pntd.0003824 . ISSN   1935-2735. PMC   4475015 . PMID   26090803.
  13. Silver, Karlee L.; Zhong, Kathleen; Leke, Rose G. F.; Taylor, Diane Wallace; Kain, Kevin C. (2010-03-01). "Dysregulation of angiopoietins is associated with placental malaria and low birth weight". PLOS ONE. 5 (3): e9481. Bibcode:2010PLoSO...5.9481S. doi: 10.1371/journal.pone.0009481 . ISSN   1932-6203. PMC   2830425 . PMID   20208992.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.