Angiopoietin 1

Last updated

ANGPT1
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases ANGPT1 , AGP1, AGPT, ANG1, angiopoietin 1, HAE5, AGPT-1
External IDs OMIM: 601667; MGI: 108448; HomoloGene: 37447; GeneCards: ANGPT1; OMA:ANGPT1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001146
NM_001199859
NM_001314051
NM_139290

NM_009640
NM_001286062

RefSeq (protein)

NP_001137
NP_001186788
NP_001300980

NP_001272991
NP_033770

Location (UCSC) Chr 8: 107.25 – 107.5 Mb Chr 15: 42.29 – 42.54 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1.

Contents

Angiopoietins are proteins with important roles in vascular development and angiogenesis. All angiopoietins bind with similar affinity to an endothelial cell-specific tyrosine-protein kinase receptor. The protein encoded by this gene is a secreted glycoprotein that activates the receptor by inducing its tyrosine phosphorylation. It plays a critical role in mediating reciprocal interactions between the endothelium and surrounding matrix and mesenchyme. The protein also contributes to blood vessel maturation and stability, and may be involved in early development of the heart. [5] During pregnancy, angiopoietins act complementary to the VEGF system and contribute to endothelial cell survival and the remodeling of vessels. Few studies have examined the role of angiopoietins in human pregnancy complications like preeclampsia and intrauterine growth restriction (IUGR).

A knockout model of ANGPT1 was introduced in mice embryos. Results showed that embryos began to appear abnormal by day 11 and were dead by day 12.5 of pregnancy. The embryos showed prominent defects in endocardial and myocardial development as well as a less complex vascular network.

[6] [7]

Interactions

Angiopoietin 1 has been shown to interact with TEK tyrosine kinase. [8] [9] [10] [11]

Placental Malaria

Recently, studies in malaria-endemic areas suggest that placental malaria (PM) may be associated with a dysregulation in angiopoietins. Increased levels of angiopoietin-1 appear to be associated with a decrease in placental weight and placental barrier thickness in women infected with Plasmodium (the causative agent of malaria). [12] In a mouse model of PM, Plasmodium infection of pregnant mice led to decreased angiopoietin-1, increased angiopoietin-2, and an elevated ratio of angiopoietin-2/angiopoietin-1 in the placenta. [13] This suggests that angiopoietin levels could be clinically significant biomarkers to identify mothers infected with PM.

See also

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000154188 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000022309 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. "Entrez Gene: ANGPT1 angiopoietin 1".
  6. Suri C, Jones PF, Patan S, Bartunkova S, Maisonpierre PC, Davis S, et al. (1996). "Requisite Role of Angiopoietin-1, a Ligand for the TIE2 Receptor, during Embryonic Angiogenesis". Cell. 87 (7): 1171–1180. doi: 10.1016/S0092-8674(00)81813-9 . PMID   8980224. S2CID   15926708.
  7. Kappou D, Sifakis S, Konstantinidou A, et al. Role of angiopoietin/Tie system in pregnancy.Experimental and Therapeutic Medicine. 2015; 9(4): 1091-1096.
  8. Fiedler U, Krissl T, Koidl S, Weiss C, Koblizek T, Deutsch U, et al. (Jan 2003). "Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeats". J. Biol. Chem. 278 (3). United States: 1721–1727. doi: 10.1074/jbc.M208550200 . ISSN   0021-9258. PMID   12427764.
  9. Davis S, Aldrich TH, Jones PF, Acheson A, Compton DL, Jain V, et al. (Dec 1996). "Isolation of angiopoietin-1, a ligand for the TIE2 receptor, by secretion-trap expression cloning". Cell. 87 (7). United States: 1161–1169. doi: 10.1016/S0092-8674(00)81812-7 . ISSN   0092-8674. PMID   8980223. S2CID   17197564.
  10. Sato A (Aug 1998). "Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cells". Int. Immunol. 10 (8). ENGLAND: 1217–1227. doi: 10.1093/intimm/10.8.1217 . ISSN   0953-8178. PMID   9723709.
  11. Maisonpierre PC, Suri C, Jones PF, Bartunkova S, Wiegand SJ, Radziejewski C, et al. (Jul 1997). "Angiopoietin-2, a natural antagonist for Tie2 that disrupts in vivo angiogenesis". Science . 277 (5322). UNITED STATES: 55–60. doi:10.1126/science.277.5322.55. ISSN   0036-8075. PMID   9204896.
  12. Ataíde R, Murillo O, Dombrowski JG, Souza RM, Lima FA, Lima GF, et al. (2015-06-19). "Malaria in Pregnancy Interacts with and Alters the Angiogenic Profiles of the Placenta". PLOS Neglected Tropical Diseases. 9 (6) e0003824. doi: 10.1371/journal.pntd.0003824 . ISSN   1935-2735. PMC   4475015 . PMID   26090803.
  13. Silver KL, Zhong K, Leke RG, Taylor DW, Kain KC (2010-03-01). "Dysregulation of angiopoietins is associated with placental malaria and low birth weight". PLOS ONE. 5 (3) e9481. Bibcode:2010PLoSO...5.9481S. doi: 10.1371/journal.pone.0009481 . ISSN   1932-6203. PMC   2830425 . PMID   20208992.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.