Keratinocyte growth factor

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The keratinocyte growth factor (KGF), also known as FGF7 , is a growth factor present in the epithelialization-phase of wound healing. In this phase, keratinocytes are covering the wound, forming the epithelium.

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KGF is a small signaling molecule that binds to fibroblast growth factor receptor 2b (FGFR2b). [1] For signalling to occur, a dimer is required between two FGF:FGFR complexes that is linked together by a molecule of heparin.

There are 23 known FGFs, and 4 FGF receptors. FGF:FGFR binding is complex and regulated by a variety of mechanisms in a tissue specific manner.

FGF10 is also known as "keratinocyte growth factor 2". [2]

See also

References

  1. ↑ Rotolo S, Ceccarelli S, Romano F, Frati L, Marchese C, Angeloni A (2008). Maas S (ed.). "Silencing of Keratinocyte Growth Factor Receptor Restores 5-Fluorouracil and Tamoxifen Efficacy on Responsive Cancer Cells". PLOS ONE. 3 (6) e2528. Bibcode:2008PLoSO...3.2528R. doi: 10.1371/journal.pone.0002528 . PMC   2424182 . PMID   18575591. Open Access logo PLoS transparent.svg
  2. ↑ "iHOP - Information Hyperlinked over Proteins [ FGF10 ]". Archived from the original on 2012-02-14.
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