Dacomitinib

Last updated

Dacomitinib
Dacomitinib.svg
Clinical data
Pronunciationdak" oh mi' ti nib
Trade names Vizimpro
Other namesPF-00299804
AHFS/Drugs.com Monograph
MedlinePlus a618055
License data
Routes of
administration 		By mouth
ATC code
Legal status
Legal status
Pharmacokinetic data
Bioavailability 80%
Protein binding 98%
Metabolism CYP2D6, CYP3A4
Metabolites O-desmethyl-dacomitinib
Elimination half-life 70 hrs
Excretion 79% faeces, 3% urine
Identifiers
  • (2E)-N-{4-[(3-Chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl}-4-(1-piperidinyl)-2-butenamide
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
PDB ligand
CompTox Dashboard (EPA)
Chemical and physical data
Formula C24H25ClFN5O2
Molar mass 469.95 g·mol−1
3D model (JSmol)
  • COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)/C=C/CN4CCCCC4
  • InChI=1S/C24H25ClFN5O2/c1-33-22-14-20-17(24(28-15-27-20)29-16-7-8-19(26)18(25)12-16)13-21(22)30-23(32)6-5-11-31-9-3-2-4-10-31/h5-8,12-15H,2-4,9-11H2,1H3,(H,30,32)(H,27,28,29)/b6-5+
  • Key:LVXJQMNHJWSHET-AATRIKPKSA-N

Dacomitinib, sold under the brand name Vizimpro, is a medication for the treatment of non-small-cell lung carcinoma (NSCLC). It is a selective and irreversible inhibitor of EGFR. [3]

Dacomitinib has advanced to several Phase III clinical trials. In January 2014, results of the first trials were disappointing, with a failure to meet the study goals, [4] [5] [6] but additional Phase III trials continued. [4] In 2017, results of a trial comparing dacomitinib to gefitinib for NSCLC (driven by mutated EGFR) were announced. [7]

Dacomitinib was approved for medical use in the United States in September 2018, [8] in Japan in 2019, and in the European Union in 2019; [9] for the treatment of non-small cell lung cancer with epidermal growth factor receptor (EGFR) gene mutation.

References

  1. ↑ "Vizimpro Product information". Health Canada. 25 April 2012. Retrieved 29 May 2022.
  2. ↑ "Summary Basis of Decision (SBD) for Verzenio". Health Canada . 23 October 2014. Retrieved 29 May 2022.
  3. ↑ "Dacomitinib". NCI Drug Dictionary. National Cancer Institute, U.S. Department of Health and Human Services.
  4. 1 2 Chustecka Z (27 January 2014). "Dacomitinib Fails in Pretreated Non-small Cell Lung Cancer". Medscape.
  5. ↑ Taylor P (28 January 2014). "Blow to Pfizer as dacomitinib fails in lung cancer trials". pmlive.com.
  6. ↑ "Pfizer Announces Top-Line Results From Two Phase 3 Trials Of Dacomitinib In Patients With Refractory Advanced Non-Small Cell Lung Cancer". Pfizer Press Release. 27 January 2014.
  7. ↑ Smith M (6 June 2017). "Dacomitinib Sets PFS Record in Phase III NSCLC Trial". MedPage Today.
  8. ↑ Shirley M (December 2018). "Dacomitinib: First Global Approval". Drugs. 78 (18): 1947–1953. doi: 10.1007/s40265-018-1028-x . PMID   30506139. S2CID   54034570.
  9. ↑ "Vizimpro EPAR". European Medicines Agency (EMA). 5 June 2019. Retrieved 13 December 2019.
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