Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene. [5]
Contents
Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1 [6]
Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene. [5]
Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1 [6]
ANGPT2 has been shown to interact with TEK tyrosine kinase. [7] [8] [9]
Neurotrophin-3 is a protein that in humans is encoded by the NTF3 gene.
Angiopoietin is part of a family of vascular growth factors that play a role in embryonic and postnatal angiogenesis. Angiopoietin signaling most directly corresponds with angiogenesis, the process by which new arteries and veins form from preexisting blood vessels. Angiogenesis proceeds through sprouting, endothelial cell migration, proliferation, and vessel destabilization and stabilization. They are responsible for assembling and disassembling the endothelial lining of blood vessels. Angiopoietin cytokines are involved with controlling microvascular permeability, vasodilation, and vasoconstriction by signaling smooth muscle cells surrounding vessels. There are now four identified angiopoietins: ANGPT1, ANGPT2, ANGPTL3, ANGPT4.
Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1.
Angiopoietin-1 receptor also known as CD202B is a protein that in humans is encoded by the TEK gene. Also known as TIE2, it is an angiopoietin receptor.
Sphingosine-1-phosphate receptor 3 also known as S1PR3 is a human gene which encodes a G protein-coupled receptor which binds the lipid signaling molecule sphingosine 1-phosphate (S1P). Hence this receptor is also known as S1P3.
Endothelin receptor type A, also known as ETA, is a human G protein-coupled receptor.
EPH receptor A2 is a protein that in humans is encoded by the EPHA2 gene.
Ephrin type-B receptor 1 is a protein that in humans is encoded by the EPHB1 gene.
C-fos-induced growth factor (FIGF) is a vascular endothelial growth factor that in humans is encoded by the FIGF gene.
Discoidin domain-containing receptor 2, also known as CD167b, is a protein that in humans is encoded by the DDR2 gene. Discoidin domain-containing receptor 2 is a receptor tyrosine kinase (RTK).
Angiopoietin-related protein 1 also known as angiopoietin-3 (ANG-3) is a protein that in humans is encoded by the ANGPTL1 gene.
TNFAIP3-interacting protein 2 is a protein that in humans is encoded by the TNIP2 gene. TNIP2 contains multiple amino acid sites that are phosphorylated and ubiquitinated.
Stabilin-1 is a protein that in humans is encoded by the STAB1 gene.
Vascular endothelial growth factor B also known as VEGF-B is a protein that, in humans, is encoded by the VEGF-B gene. VEGF-B is a growth factor that belongs to the vascular endothelial growth factor family, of which VEGF-A is the best-known member.
Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene.
Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene.
Carbohydrate sulfotransferase 1 is an enzyme that in humans is encoded by the CHST1 gene.
Early growth response protein 3 is a protein in humans, encoded by the EGR3 gene.
Angiopoietin-related protein 2 also known as angiopoietin-like protein 2 is a protein that in humans is encoded by the ANGPTL2 gene.
Thomas N. Sato is a prominent Japanese educator, entrepreneur, and biologist, whose research focuses on understanding molecular basis of cancer, cardiac disease and metabolic diseases by using a number of animal models including mice, zebrafish and fruit flies. He is also working to invent next-generation therapeutics for human diseases based on the stochastic basis of life and disease. He is currently director of the Thomas N. Sato BioMEC-X Laboratories at the Advanced Telecommunications Research Institute International (ATR) in Kyoto, research director of the ERATO Sato Live Bio-forecasting project JST in Kyoto, scientific founder and chair of board of directors Karydo TherapeutiX, Inc, professor of Virtual Human InformatiX Clinic in Nara, and affiliate professor at Centenary Institute in Sydney, Australia. He is also a triathlete who competes at Ironman distance including Ironman Lake Placid, Ironman Japan, Ironman Coeur d’Alene.
PDB gallery | |
|---|---|
|
This article incorporates text from the United States National Library of Medicine, which is in the public domain.
 | This article on a gene on human chromosome 8 is a stub. You can help Wikipedia by expanding it. |
