Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene. [5]
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Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1 [6]
Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene. [5]
Naturally occurring antagonist for both ANGPT1 and TIE2; expressed only at the sites of vascular remodeling; similar to angiopoietin-1 [6]
ANGPT2 has been shown to interact with TEK tyrosine kinase. [7] [8] [9]
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FGF1, also known as acidic fibroblast growth factor (aFGF), is a growth factor and signaling protein encoded by the FGF1 gene. It is synthesized as a 155 amino acid polypeptide, whose mature form is a non-glycosylated 17-18 kDa protein. Fibroblast growth factor protein was first purified in 1975, but soon afterwards others using different conditions isolated acidic FGF, Heparin-binding growth factor-1, and Endothelial cell growth factor-1. Gene sequencing revealed that this group was actually the same growth factor and that FGF1 was a member of a family of FGF proteins.
Angiopoietin is part of a family of vascular growth factors that play a role in embryonic and postnatal angiogenesis. Angiopoietin signaling most directly corresponds with angiogenesis, the process by which new arteries and veins form from preexisting blood vessels. Angiogenesis proceeds through sprouting, endothelial cell migration, proliferation, and vessel destabilization and stabilization. They are responsible for assembling and disassembling the endothelial lining of blood vessels. Angiopoietin cytokines are involved with controlling microvascular permeability, vasodilation, and vasoconstriction by signaling smooth muscle cells surrounding vessels. There are now four identified angiopoietins: ANGPT1, ANGPT2, ANGPTL3, ANGPT4.
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Thomas N. Sato (佐藤匠徳) is a prominent Japanese educator, entrepreneur, and biologist, whose research focuses on understanding molecular basis of cancer, cardiac disease and metabolic diseases by using a number of animal models including mice, zebrafish and fruit flies. He is also working to invent next-generation therapeutics for human diseases based on the stochastic basis of life and disease. He is currently director of the Thomas N. Sato BioMEC-X Laboratories at the Advanced Telecommunications Research Institute International (ATR) in Kyoto, research director of the ERATO Sato Live Bio-forecasting project JST in Kyoto, scientific founder and chair of board of directors Karydo TherapeutiX, Inc, professor of Virtual Human InformatiX Clinic in Nara, and affiliate professor at Centenary Institute in Sydney, Australia. He is also a triathlete who competes at Ironman distance including Ironman Lake Placid, Ironman Japan, Ironman Coeur d’Alene.
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