| AATK | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Identifiers | |||||||||||||||||||||||||||||||||||||||||||||||||||
| Aliases | AATK , AATYK, AATYK1, LMR1, LMTK1, PPP1R77, p35BP, apoptosis-associated tyrosine kinase, aatyk1, mKIAA0641, apoptosis associated tyrosine kinase | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 605276; MGI: 1197518; HomoloGene: 74861; GeneCards: AATK; OMA:AATK - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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| Wikidata | |||||||||||||||||||||||||||||||||||||||||||||||||||
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Serine/threonine-protein kinase LMTK1 (also known as Apoptosis-associated tyrosine kinase) is an enzyme that in humans is encoded by the (AATK) gene. [5] [6] [7]
The gene was identified in 1998. It is located on chromosome 17 (17q25.3) and is expressed in the pancreas, kidney, brain and lungs. The protein is composed of 1,207 amino acids. [5] [6]
The protein contains a tyrosine kinase domain at the N-terminal end and a proline-rich domain at the C-terminal end. Studies of the mouse homologue have indicated that it may be necessary for the induction of growth arrest and/or apoptosis of myeloid precursor cells. It may also have a role in inducing differentiation in neuronal cells. [7] [8] Its suppressive role on melanoma development has been reported recently. [9]
AATK is thought to indirectly inhibit the SPAK/WNK4 activation of the Na-K-Cl cotransporter. [10]
Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1.
Neurogenic differentiation 1 (Neurod1), also called β2, is a transcription factor of the NeuroD-type. It is encoded by the human gene NEUROD1.
WNK , also known as WNK1, is an enzyme that is encoded by the WNK1 gene. WNK1 is serine-threonine protein kinase and part of the "with no lysine/K" kinase WNK family. The predominant role of WNK1 is the regulation of cation-Cl− cotransporters (CCCs) such as the sodium chloride cotransporter (NCC), basolateral Na-K-Cl symporter (NKCC1), and potassium chloride cotransporter (KCC1) located within the kidney. CCCs mediate ion homeostasis and modulate blood pressure by transporting ions in and out of the cell. WNK1 mutations as a result have been implicated in blood pressure disorders/diseases; a prime example being familial hyperkalemic hypertension (FHHt).
ARF GTPase-activating protein GIT2 is an enzyme that in humans is encoded by the GIT2 gene.
EPH receptor A5 is a protein that in humans is encoded by the EPHA5 gene.
Heat shock protein 105 kDa is a protein that in humans is encoded by the HSPH1 gene.
Wiskott–Aldrich syndrome protein family member 3 is a protein that in humans is encoded by the WASF3 gene.
Serine/threonine-protein kinase OSR1 is an enzyme that in humans is encoded by the OXSR1 gene.
Serine/threonine protein kinase WNK4 also known as WNK lysine deficient protein kinase 4 or WNK4, is an enzyme that in humans is encoded by the WNK4 gene. Missense mutations cause a genetic form of pseudohypoaldosteronism type 2, also called Gordon syndrome.
SNF-related serine/threonine-protein kinase is an enzyme that in humans is encoded by the SNRK gene.
Receptor-type tyrosine-protein phosphatase gamma is an enzyme that in humans is encoded by the PTPRG gene.
Potassium-chloride transporter member 5 is a neuron-specific chloride potassium symporter responsible for establishing the chloride ion gradient in neurons through the maintenance of low intracellular chloride concentrations. It is a critical mediator of synaptic inhibition, cellular protection against excitotoxicity and may also act as a modulator of neuroplasticity. Potassium-chloride transporter member 5 is also known by the names: KCC2 for its ionic substrates, and SLC12A5 for its genetic origin from the SLC12A5 gene in humans.
CAP-Gly domain-containing linker protein 2 is a protein that in humans is encoded by the CLIP2 gene.
Glucocorticoid receptor DNA-binding factor 1 is a protein that in humans is encoded by the GRLF1 gene.
Neurogenic differentiation factor 2 is a protein that in humans is encoded by the NEUROD2 gene.
A-kinase anchor protein 6 is an enzyme that in humans is encoded by the AKAP6 gene.
Solute carrier family 12 member 7 is a protein that in humans is encoded by the SLC12A7 gene.
STE20/SPS1-related proline-alanine-rich protein kinase is an enzyme that in humans is encoded by the STK39 gene.
PH domain and leucine rich repeat protein phosphatase, also known as PHLPP, is an enzyme which in humans is encoded by the PHLPP gene.
Adenylate kinase isoenzyme 4, mitochondrial is an enzyme that in humans is encoded by the AK4 gene.
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