Tyrosine-protein kinase BLK

Last updated

BLK
Identifiers
Aliases BLK , MODY11, BLK proto-oncogene, Src family tyrosine kinase
External IDs OMIM: 191305; MGI: 88169; HomoloGene: 1297; GeneCards: BLK; OMA:BLK - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_001715
NM_001330465

NM_007549

RefSeq (protein)

NP_001317394
NP_001706

NP_031575

Location (UCSC) Chr 8: 11.49 – 11.56 Mb Chr 14: 63.61 – 63.65 Mb
PubMed search [3] [4]
Wikidata
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Tyrosine-protein kinase BLK, also known as B lymphocyte kinase, is a non-receptor tyrosine kinase that in humans is encoded by the BLK gene. [5] [6] It is of the Src family of tyrosine kinases.

Contents

Interactions

The tyrosine-protein kinase BLK has been shown to interact with UBE3A. [7]

References

  1. 1 2 3 ENSG00000285369 GRCh38: Ensembl release 89: ENSG00000136573, ENSG00000285369 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014453 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Drebin JA, Hartzell SW, Griffin C, Campbell MJ, Niederhuber JE (Mar 1995). "Molecular cloning and chromosomal localization of the human homologue of a B-lymphocyte specific protein tyrosine kinase (blk)". Oncogene. 10 (3): 477–86. PMID   7845672.
  6. "Entrez Gene: BLK B lymphoid tyrosine kinase".
  7. Oda H, Kumar S, Howley PM (August 1999). "Regulation of the Src family tyrosine kinase Blk through E6AP-mediated ubiquitination". Proc. Natl. Acad. Sci. U.S.A. 96 (17): 9557–62. Bibcode:1999PNAS...96.9557O. doi: 10.1073/pnas.96.17.9557 . PMC   22247 . PMID   10449731.

Further reading