EPHB6

EPHB6
Identifiers
Aliases	EPHB6 , HEP, EPH receptor B6
External IDs	OMIM: 602757 MGI: 1096338 HomoloGene: 20940 GeneCards: EPHB6
Gene location (Human) Chr. Chromosome 7 (human) [1] Band 7q34 Start 142,855,061 bp [1] End 142,871,094 bp [1]
Gene location (Mouse) Chr. Chromosome 6 (mouse) [2] Band 6|6 B2.1 Start 41,582,416 bp [2] End 41,597,443 bp [2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in superior frontal gyrus putamen caudate nucleus dorsolateral prefrontal cortex skin of abdomen Brodmann area 9 prefrontal cortex nucleus accumbens ganglionic eminence temporal lobe Top expressed in lip superior frontal gyrus pleural cavity pericardium pericardial cavity prefrontal cortex thymus skin of back esophagus squamous epithelium More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding protein kinase activity protein binding ATP binding ephrin receptor activity signaling receptor activity protein tyrosine kinase activity receptor tyrosine kinase transmembrane signaling receptor activity transmembrane-ephrin receptor activity transmembrane receptor protein tyrosine kinase activity Cellular component integral component of membrane extracellular region cytosol plasma membrane integral component of plasma membrane membrane cytoplasm neuron projection receptor complex Biological process protein phosphorylation transmembrane receptor protein tyrosine kinase signaling pathway ephrin receptor signaling pathway peptidyl-tyrosine phosphorylation negative regulation of signal transduction cell differentiation negative regulation of apoptotic process positive regulation of ERK1 and ERK2 cascade axon guidance Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 2051 13848 Ensembl ENSG00000106123 ENSG00000275482 ENSMUSG00000029869 UniProt O15197 O08644 RefSeq (mRNA) NM_001280794 NM_001280795 NM_004445 NM_001146351 NM_007680 RefSeq (protein) NP_001267723 NP_001267724 NP_004436 NP_001139823 NP_031706 Location (UCSC) Chr 7: 142.86 – 142.87 Mb Chr 6: 41.58 – 41.6 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Ephrin type-B receptor 6 is a protein that in humans is encoded by the EPHB6 gene. ^[5]

Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The ephrin receptor encoded by this gene lacks the kinase activity of most receptor tyrosine kinases and binds to ephrin-B ligands. ^[5]

References

1. ENSG00000275482 GRCh38: Ensembl release 89: ENSG00000106123, ENSG00000275482 - Ensembl, May 2017
2. GRCm38: Ensembl release 89: ENSMUSG00000029869 - Ensembl, May 2017
3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
5. "Entrez Gene: EPHB6 EPH receptor B6".

Further reading

• Flanagan JG, Vanderhaeghen P (1998). "The ephrins and Eph receptors in neural development". Annu. Rev. Neurosci. 21: 309–45. doi:10.1146/annurev.neuro.21.1.309. PMID   9530499.
• Zhou R (1998). "The Eph family receptors and ligands". Pharmacol. Ther. 77 (3): 151–81. doi:10.1016/S0163-7258(97)00112-5. PMID   9576626.
• Holder N, Klein R (1999). "Eph receptors and ephrins: effectors of morphogenesis". Development. 126 (10): 2033–44. doi:10.1242/dev.126.10.2033. PMID   10207129.
• Wilkinson DG (2000). "Eph receptors and ephrins: regulators of guidance and assembly; Chapter: Eph receptors and ephrins: Regulators of guidance and assembly". Int. Rev. Cytol. International Review of Cytology. 196: 177–244. doi:10.1016/S0074-7696(00)96005-4. ISBN   978-0-12-364600-2. PMID   10730216.
• Xu Q, Mellitzer G, Wilkinson DG (2001). "Roles of Eph receptors and ephrins in segmental patterning". Philos. Trans. R. Soc. Lond. B Biol. Sci. 355 (1399): 993–1002. doi:10.1098/rstb.2000.0635. PMC   1692797 . PMID   11128993.
• Wilkinson DG (2001). "Multiple roles of EPH receptors and ephrins in neural development". Nat. Rev. Neurosci. 2 (3): 155–64. doi:10.1038/35058515. PMID   11256076. S2CID   205014301.
• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery". Genome Res. 6 (9): 791–806. doi: 10.1101/gr.6.9.791 . PMID   8889548.
• Matsuoka H, Iwata N, Ito M, et al. (1997). "Expression of a kinase-defective Eph-like receptor in the normal human brain". Biochem. Biophys. Res. Commun. 235 (3): 487–92. doi:10.1006/bbrc.1997.6812. PMID   9207182.
• Ephnomenclaturecommittee (1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi: 10.1016/S0092-8674(00)80500-0 . PMID   9267020. S2CID   26773768.
• Hock B, Böhme B, Karn T, et al. (1998). "PDZ-domain-mediated interaction of the Eph-related receptor tyrosine kinase EphB3 and the ras-binding protein AF6 depends on the kinase activity of the receptor". Proc. Natl. Acad. Sci. U.S.A. 95 (17): 9779–84. Bibcode:1998PNAS...95.9779H. doi: 10.1073/pnas.95.17.9779 . PMC   21413 . PMID   9707552.
• Munthe E, Rian E, Holien T, et al. (2000). "Ephrin-B2 is a candidate ligand for the Eph receptor, EphB6". FEBS Lett. 466 (1): 169–74. doi: 10.1016/S0014-5793(99)01793-7 . PMID   10648835. S2CID   40328521.
• Shimoyama M, Matsuoka H, Tamekane A, et al. (2000). "T-cell-specific expression of kinase-defective Eph-family receptor protein, EphB6 in normal as well as transformed hematopoietic cells". Growth Factors. 18 (1): 63–78. doi:10.3109/08977190009003234. PMID   10831073. S2CID   9397812.
• Tang XX, Zhao H, Robinson ME, et al. (2000). "Implications of EPHB6, EFNB2, and EFNB3 expressions in human neuroblastoma". Proc. Natl. Acad. Sci. U.S.A. 97 (20): 10936–41. doi: 10.1073/pnas.190123297 . PMC   27127 . PMID   10984508.
• Luo H, Wan X, Wu Y, Wu J (2001). "Cross-linking of EphB6 resulting in signal transduction and apoptosis in Jurkat cells". J. Immunol. 167 (3): 1362–70. doi: 10.4049/jimmunol.167.3.1362 . PMID   11466354.