EPH receptor A5

Last updated
EPHA5
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases EPHA5 , CEK7, EHK-1, EHK1, EK7, HEK7, TYRO4, EPH receptor A5
External IDs OMIM: 600004; MGI: 99654; HomoloGene: 55824; GeneCards: EPHA5; OMA:EPHA5 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_007937

RefSeq (protein)
Location (UCSC) Chr 4: 65.32 – 65.67 Mb Chr 5: 84.2 – 84.57 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

EPH receptor A5 (ephrin type-A receptor 5) is a protein that in humans is encoded by the EPHA5 gene. [5] [6] [7]

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. [7]

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000145242 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000029245 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Ephnomenclaturecommittee (Sep 1997). "Unified nomenclature for Eph family receptors and their ligands, the ephrins. Eph Nomenclature Committee". Cell. 90 (3): 403–4. doi: 10.1016/S0092-8674(00)80500-0 . PMID   9267020. S2CID   26773768.
  6. Spritz RA, Strunk KM, Lee ST, Lu-Kuo JM, Ward DC, Le Paslier D, Altherr MR, Dorman TE, Moir DT (Jan 1995). "A YAC contig spanning a cluster of human type III receptor protein tyrosine kinase genes (PDGFRA-KIT-KDR) in chromosome segment 4q12". Genomics. 22 (2): 431–6. doi: 10.1006/geno.1994.1405 . PMID   7528718.
  7. 1 2 "Entrez Gene: EPHA5 EPH receptor A5".

Further reading