TIE1

Last updated
TIE1
Identifiers
Aliases TIE1 , JTK14, TIE, tyrosine kinase with immunoglobulin like and EGF like domains 1, LMPHM11
External IDs OMIM: 600222 MGI: 99906 HomoloGene: 3957 GeneCards: TIE1
Orthologs
SpeciesHumanMouse
Entrez

7075

21846

Ensembl

ENSG00000066056

ENSMUSG00000033191

UniProt

P35590

Q06806

RefSeq (mRNA)

NM_001253357
NM_005424

NM_011587

RefSeq (protein)

NP_001240286
NP_005415

NP_035717

Location (UCSC) Chr 1: 43.3 – 43.32 Mb Chr 4: 118.47 – 118.49 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse
tyrosine kinase with immunoglobulin-like and EGF-like domains 1
Identifiers
SymbolTIE1
Alt. symbolsTIE, JTK14
NCBI gene 7075
HGNC 11809
OMIM 600222
RefSeq NM_005424
UniProt P35590
Other data
EC number 2.7.1.112
Locus Chr. 1 p34-p33

Tyrosine kinase with immunoglobulin-like and EGF-like domains 1 also known as TIE1 is an angiopoietin receptor which in humans is encoded by the TIE1 gene. [5]

Contents

Function

TIE1 is a cell surface protein expressed exclusively in endothelial cells, however it has also been shown to be expressed in immature hematopoietic cells [6] and platelets. [7] TIE1 upregulates the cell adhesion molecules (CAMs) VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. Attachment of monocyte derived immune cells to endothelial cells is also enhanced by TIE1 expression. TIE1 has a proinflammatory effect and may play a role in the endothelial inflammatory diseases such as atherosclerosis. [8]

See also

Related Research Articles

P-selectin glycoprotein ligand-1

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CD31

Platelet endothelial cell adhesion molecule (PECAM-1) also known as cluster of differentiation 31 (CD31) is a protein that in humans is encoded by the PECAM1 gene found on chromosome17q23.3. PECAM-1 plays a key role in removing aged neutrophils from the body.

VCAM-1

Vascular cell adhesion protein 1 also known as vascular cell adhesion molecule 1 (VCAM-1) or cluster of differentiation 106 (CD106) is a protein that in humans is encoded by the VCAM1 gene. VCAM-1 functions as a cell adhesion molecule.

Angiopoietin Protein family

Angiopoietin is part of a family of vascular growth factors that play a role in embryonic and postnatal angiogenesis. Angiopoietin signaling most directly corresponds with angiogenesis, the process by which new arteries and veins form from preexisting blood vessels. Angiogenesis proceeds through sprouting, endothelial cell migration, proliferation, and vessel destabilization and stabilization. They are responsible for assembling and disassembling the endothelial lining of blood vessels. Angiopoietin cytokines are involved with controlling microvascular permeability, vasodilation, and vasoconstriction by signaling smooth muscle cells surrounding vessels. There are now four identified angiopoietins: ANGPT1, ANGPT2, ANGPTL3, ANGPT4.

Interleukin 19

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Angiopoietin 1

Angiopoietin 1 is a type of angiopoietin and is encoded by the gene ANGPT1.

ANGPT2

Angiopoietin-2 is a protein that in humans is encoded by the ANGPT2 gene.

PTPN6

Tyrosine-protein phosphatase non-receptor type 6, also known as Src homology region 2 domain-containing phosphatase-1 (SHP-1), is an enzyme that in humans is encoded by the PTPN6 gene.

VEGFR1 Protein-coding gene in the species Homo sapiens

Vascular endothelial growth factor receptor 1 is a protein that in humans is encoded by the FLT1 gene.

Kinase insert domain receptor

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TEK tyrosine kinase

Angiopoietin-1 receptor also known as CD202B is a protein that in humans is encoded by the TEK gene. Also known as TIE2, it is an angiopoietin receptor.

YES1

Proto-oncogene tyrosine-protein kinase Yes is a non-receptor tyrosine kinase that in humans is encoded by the YES1 gene.

F11 receptor

Junctional adhesion molecule A is a protein that in humans is encoded by the F11R gene. It has also been designated as CD321.

PTPRB

Receptor-type tyrosine-protein phosphatase beta or VE-PTP is an enzyme specifically expressed in endothelial cells that in humans is encoded by the PTPRB gene.

DAPP1

Dual adapter for phosphotyrosine and 3-phosphotyrosine and 3-phosphoinositide is a protein that in humans is encoded by the DAPP1 gene.

ANGPT4 Protein-coding gene in the species Homo sapiens

Angiopoietin-4 is a protein that in humans is encoded by the ANGPT4 gene.

PTK7

Tyrosine-protein kinase-like 7 also known as colon carcinoma kinase 4 (CCK4) is a receptor tyrosine kinase that in humans is encoded by the PTK7 gene.

Vascular endothelial growth factor A

Vascular endothelial growth factor A (VEGF-A) is a protein that in humans is encoded by the VEGFA gene.

FLT4

Fms-related tyrosine kinase 4, also known as FLT4, is a protein which in humans is encoded by the FLT4 gene.

References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000066056 - Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000033191 - Ensembl, May 2017
  3. ↑ "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. ↑ "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. ↑ Partanen J, Armstrong E, Mäkelä TP, Korhonen J, Sandberg M, Renkonen R, Knuutila S, Huebner K, Alitalo K (April 1992). "A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains". Molecular and Cellular Biology. 12 (4): 1698–707. doi:10.1128/mcb.12.4.1698. PMC   369613 . PMID   1312667.
  6. ↑ Rodewald HR, Sato TN (January 1996). "Tie1, a receptor tyrosine kinase essential for vascular endothelial cell integrity, is not critical for the development of hematopoietic cells". Oncogene. 12 (2): 397–404. PMID   8570217.
  7. ↑ Tsiamis AC, Hayes P, Box H, Goodall AH, Bell PR, Brindle NP (2000). "Characterization and regulation of the receptor tyrosine kinase Tie-1 in platelets". Journal of Vascular Research. 37 (6): 437–42. doi:10.1159/000054075. PMID   11146396. S2CID   43509019.
  8. ↑ Chan B, Yuan HT, Ananth Karumanchi S, Sukhatme VP (July 2008). "Receptor tyrosine kinase Tie-1 overexpression in endothelial cells upregulates adhesion molecules". Biochemical and Biophysical Research Communications. 371 (3): 475–9. doi:10.1016/j.bbrc.2008.04.091. PMID   18448073.
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