Tyrosine-protein kinase Yes

Last updated
YES1
Protein YES1 PDB 2hda.png
Available structures
PDB Ortholog search: PDBe RCSB
Identifiers
Aliases YES1 , HsT441, P61-YES, Yes, c-yes, YES proto-oncogene 1, Src family tyrosine kinase
External IDs OMIM: 164880; MGI: 99147; HomoloGene: 55900; GeneCards: YES1; OMA:YES1 - orthologs
Orthologs
SpeciesHumanMouse
Entrez
Ensembl
UniProt
RefSeq (mRNA)

NM_005433

NM_001205132
NM_001205133
NM_009535

RefSeq (protein)

NP_005424

NP_001192061
NP_001192062
NP_033561

Location (UCSC) Chr 18: 0.72 – 0.81 Mb Chr 5: 32.77 – 32.84 Mb
PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse

Tyrosine-protein kinase Yes is a non-receptor tyrosine kinase that in humans is encoded by the YES1 gene. [5] [6]

Contents

This gene is the cellular homolog of the Yamaguchi sarcoma virus oncogene. The encoded protein has tyrosine kinase activity and belongs to the src family. This gene lies in close proximity to thymidylate synthase gene on chromosome 18, and a corresponding pseudogene has been found on chromosome 22. [6]

Interactions

YES1 has been shown to interact with Janus kinase 2, [7] CTNND1, [8] RPL10 [9] and Occludin. [10]

Related Research Articles

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<span class="mw-page-title-main">PTPN12</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">ABL2</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">Megakaryocyte-associated tyrosine kinase</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">FER (gene)</span> Protein-coding gene in the species Homo sapiens

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<span class="mw-page-title-main">PTK6</span> Protein-coding gene in the species Homo sapiens

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References

  1. 1 2 3 GRCh38: Ensembl release 89: ENSG00000176105 Ensembl, May 2017
  2. 1 2 3 GRCm38: Ensembl release 89: ENSMUSG00000014932 Ensembl, May 2017
  3. "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. Semba K, Yamanashi Y, Nishizawa M, Sukegawa J, Yoshida M, Sasaki M, Yamamoto T, Toyoshima K (Mar 1985). "Location of the c-yes gene on the human chromosome and its expression in various tissues". Science. 227 (4690): 1038–40. Bibcode:1985Sci...227.1038S. doi:10.1126/science.2983418. PMID   2983418.
  6. 1 2 "Entrez Gene: YES1 v-yes-1 Yamaguchi sarcoma viral oncogene homolog 1".
  7. Fuhrer, D K; Yang Y C (Jul 1996). "Complex formation of JAK2 with PP2A, P13K, and Yes in response to the hematopoietic cytokine interleukin-11". Biochem. Biophys. Res. Commun. 224 (2): 289–96. doi:10.1006/bbrc.1996.1023. ISSN   0006-291X. PMID   8702385.
  8. Piedra, Jose; Miravet Susana; Castaño Julio; Pálmer Héctor G; Heisterkamp Nora; García de Herreros Antonio; Duñach Mireia (Apr 2003). "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha-catenin Interaction" (PDF). Mol. Cell. Biol. 23 (7): 2287–97. doi:10.1128/MCB.23.7.2287-2297.2003. ISSN   0270-7306. PMC   150740 . PMID   12640114.
  9. Oh, Hyung Suk; Kwon Haeyoung; Sun Suk Kyun; Yang Chul-Hak (Sep 2002). "QM, a putative tumor suppressor, regulates proto-oncogene c-yes". J. Biol. Chem. 277 (39): 36489–98. doi: 10.1074/jbc.M201859200 . ISSN   0021-9258. PMID   12138090.
  10. Chen, Yan-Hua; Lu Qun; Goodenough Daniel A; Jeansonne Beverly (Apr 2002). "Nonreceptor tyrosine kinase c-Yes interacts with occludin during tight junction formation in canine kidney epithelial cells". Mol. Biol. Cell. 13 (4): 1227–37. doi:10.1091/mbc.01-08-0423. ISSN   1059-1524. PMC   102264 . PMID   11950934.

Further reading